163 related articles for article (PubMed ID: 25148516)
1. Orally bioavailable 6-chloro-7-methoxy-4(1H)-quinolones efficacious against multiple stages of Plasmodium.
Cross RM; Flanigan DL; Monastyrskyi A; LaCrue AN; Sáenz FE; Maignan JR; Mutka TS; White KL; Shackleford DM; Bathurst I; Fronczek FR; Wojtas L; Guida WC; Charman SA; Burrows JN; Kyle DE; Manetsch R
J Med Chem; 2014 Nov; 57(21):8860-79. PubMed ID: 25148516
[TBL] [Abstract][Full Text] [Related]
2. Endochin optimization: structure-activity and structure-property relationship studies of 3-substituted 2-methyl-4(1H)-quinolones with antimalarial activity.
Cross RM; Monastyrskyi A; Mutka TS; Burrows JN; Kyle DE; Manetsch R
J Med Chem; 2010 Oct; 53(19):7076-94. PubMed ID: 20828199
[TBL] [Abstract][Full Text] [Related]
3. ICI 56,780 Optimization: Structure-Activity Relationship Studies of 7-(2-Phenoxyethoxy)-4(1H)-quinolones with Antimalarial Activity.
Maignan JR; Lichorowic CL; Giarrusso J; Blake LD; Casandra D; Mutka TS; LaCrue AN; Burrows JN; Willis PA; Kyle DE; Manetsch R
J Med Chem; 2016 Jul; 59(14):6943-60. PubMed ID: 27291102
[TBL] [Abstract][Full Text] [Related]
4. Identification, design and biological evaluation of bisaryl quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2).
Pidathala C; Amewu R; Pacorel B; Nixon GL; Gibbons P; Hong WD; Leung SC; Berry NG; Sharma R; Stocks PA; Srivastava A; Shone AE; Charoensutthivarakul S; Taylor L; Berger O; Mbekeani A; Hill A; Fisher NE; Warman AJ; Biagini GA; Ward SA; O'Neill PM
J Med Chem; 2012 Mar; 55(5):1831-43. PubMed ID: 22364416
[TBL] [Abstract][Full Text] [Related]
5. 4(1H)-Quinolones with liver stage activity against Plasmodium berghei.
Lacrue AN; Sáenz FE; Cross RM; Udenze KO; Monastyrskyi A; Stein S; Mutka TS; Manetsch R; Kyle DE
Antimicrob Agents Chemother; 2013 Jan; 57(1):417-24. PubMed ID: 23129047
[TBL] [Abstract][Full Text] [Related]
6. Progress in the Optimization of 4(1
Brockmeyer F; Manetsch R
Chimia (Aarau); 2017 Apr; 71(4):213-219. PubMed ID: 28446339
[TBL] [Abstract][Full Text] [Related]
7. Identification, design and biological evaluation of heterocyclic quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2).
Leung SC; Gibbons P; Amewu R; Nixon GL; Pidathala C; Hong WD; Pacorel B; Berry NG; Sharma R; Stocks PA; Srivastava A; Shone AE; Charoensutthivarakul S; Taylor L; Berger O; Mbekeani A; Hill A; Fisher NE; Warman AJ; Biagini GA; Ward SA; O'Neill PM
J Med Chem; 2012 Mar; 55(5):1844-57. PubMed ID: 22364417
[TBL] [Abstract][Full Text] [Related]
8. Synthesis, antimalarial activity, and structure-activity relationship of 7-(2-phenoxyethoxy)-4(1H)-quinolones.
Cross RM; Namelikonda NK; Mutka TS; Luong L; Kyle DE; Manetsch R
J Med Chem; 2011 Dec; 54(24):8321-7. PubMed ID: 22111907
[TBL] [Abstract][Full Text] [Related]
9. Design and Synthesis of Orally Bioavailable Piperazine Substituted 4(1H)-Quinolones with Potent Antimalarial Activity: Structure-Activity and Structure-Property Relationship Studies.
Neelarapu R; Maignan JR; Lichorowic CL; Monastyrskyi A; Mutka TS; LaCrue AN; Blake LD; Casandra D; Mashkouri S; Burrows JN; Willis PA; Kyle DE; Manetsch R
J Med Chem; 2018 Feb; 61(4):1450-1473. PubMed ID: 29215279
[TBL] [Abstract][Full Text] [Related]
10. Role of Trifluoromethyl Substitution in Design of Antimalarial Quinolones: a Comprehensive Review.
Romero AH
Top Curr Chem (Cham); 2019 Mar; 377(2):9. PubMed ID: 30835005
[TBL] [Abstract][Full Text] [Related]
11. Structural optimization of quinolon-4(1H)-imines as dual-stage antimalarials: toward increased potency and metabolic stability.
Ressurreição AS; Gonçalves D; Sitoe AR; Albuquerque IS; Gut J; Góis A; Gonçalves LM; Bronze MR; Hanscheid T; Biagini GA; Rosenthal PJ; Prudêncio M; O'Neill P; Mota MM; Lopes F; Moreira R
J Med Chem; 2013 Oct; 56(19):7679-90. PubMed ID: 24020770
[TBL] [Abstract][Full Text] [Related]
12. Synthesis of quinolinyl chalcones and evaluation of their antimalarial activity.
Domínguez JN; Charris JE; Lobo G; Gamboa de Domínguez N; Moreno MM; Riggione F; Sanchez E; Olson J; Rosenthal PJ
Eur J Med Chem; 2001 Jun; 36(6):555-60. PubMed ID: 11525846
[TBL] [Abstract][Full Text] [Related]
13. Antimalarial quinolones: synthesis, potency, and mechanistic studies.
Winter RW; Kelly JX; Smilkstein MJ; Dodean R; Hinrichs D; Riscoe MK
Exp Parasitol; 2008 Apr; 118(4):487-97. PubMed ID: 18082162
[TBL] [Abstract][Full Text] [Related]
14. Protein farnesyltransferase inhibitors exhibit potent antimalarial activity.
Nallan L; Bauer KD; Bendale P; Rivas K; Yokoyama K; Hornéy CP; Pendyala PR; Floyd D; Lombardo LJ; Williams DK; Hamilton A; Sebti S; Windsor WT; Weber PC; Buckner FS; Chakrabarti D; Gelb MH; Van Voorhis WC
J Med Chem; 2005 Jun; 48(11):3704-13. PubMed ID: 15916422
[TBL] [Abstract][Full Text] [Related]
15. Discovery, synthesis, and optimization of antimalarial 4(1H)-quinolone-3-diarylethers.
Nilsen A; Miley GP; Forquer IP; Mather MW; Katneni K; Li Y; Pou S; Pershing AM; Stickles AM; Ryan E; Kelly JX; Doggett JS; White KL; Hinrichs DJ; Winter RW; Charman SA; Zakharov LN; Bathurst I; Burrows JN; Vaidya AB; Riscoe MK
J Med Chem; 2014 May; 57(9):3818-34. PubMed ID: 24720377
[TBL] [Abstract][Full Text] [Related]
16. Lead optimization of 3-carboxyl-4(1H)-quinolones to deliver orally bioavailable antimalarials.
Zhang Y; Clark JA; Connelly MC; Zhu F; Min J; Guiguemde WA; Pradhan A; Iyer L; Furimsky A; Gow J; Parman T; El Mazouni F; Phillips MA; Kyle DE; Mirsalis J; Guy RK
J Med Chem; 2012 May; 55(9):4205-19. PubMed ID: 22435599
[TBL] [Abstract][Full Text] [Related]
17. Flavones as isosteres of 4(1H)-quinolones: discovery of ligand efficient and dual stage antimalarial lead compounds.
Rodrigues T; Ressurreição AS; da Cruz FP; Albuquerque IS; Gut J; Carrasco MP; Gonçalves D; Guedes RC; dos Santos DJ; Mota MM; Rosenthal PJ; Moreira R; Prudêncio M; Lopes F
Eur J Med Chem; 2013 Nov; 69():872-80. PubMed ID: 24125849
[TBL] [Abstract][Full Text] [Related]
18. Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria.
Biagini GA; Fisher N; Shone AE; Mubaraki MA; Srivastava A; Hill A; Antoine T; Warman AJ; Davies J; Pidathala C; Amewu RK; Leung SC; Sharma R; Gibbons P; Hong DW; Pacorel B; Lawrenson AS; Charoensutthivarakul S; Taylor L; Berger O; Mbekeani A; Stocks PA; Nixon GL; Chadwick J; Hemingway J; Delves MJ; Sinden RE; Zeeman AM; Kocken CH; Berry NG; O'Neill PM; Ward SA
Proc Natl Acad Sci U S A; 2012 May; 109(21):8298-303. PubMed ID: 22566611
[TBL] [Abstract][Full Text] [Related]
19. Optimization of 1,2,3,4-tetrahydroacridin-9(10H)-ones as antimalarials utilizing structure-activity and structure-property relationships.
Cross RM; Maignan JR; Mutka TS; Luong L; Sargent J; Kyle DE; Manetsch R
J Med Chem; 2011 Jul; 54(13):4399-426. PubMed ID: 21630666
[TBL] [Abstract][Full Text] [Related]
20. Substituted Aminoacetamides as Novel Leads for Malaria Treatment.
Norcross NR; Wilson C; Baragaña B; Hallyburton I; Osuna-Cabello M; Norval S; Riley J; Fletcher D; Sinden R; Delves M; Ruecker A; Duffy S; Meister S; Antonova-Koch Y; Crespo B; de Cózar C; Sanz LM; Gamo FJ; Avery VM; Frearson JA; Gray DW; Fairlamb AH; Winzeler EA; Waterson D; Campbell SF; Willis PA; Read KD; Gilbert IH
ChemMedChem; 2019 Jul; 14(14):1329-1335. PubMed ID: 31188540
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
