BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

332 related articles for article (PubMed ID: 25164809)

  • 21. GLUT1 enhances mTOR activity independently of TSC2 and AMPK.
    Buller CL; Heilig CW; Brosius FC
    Am J Physiol Renal Physiol; 2011 Sep; 301(3):F588-96. PubMed ID: 21613414
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Rheb/mTORC1 signaling promotes kidney fibroblast activation and fibrosis.
    Jiang L; Xu L; Mao J; Li J; Fang L; Zhou Y; Liu W; He W; Zhao AZ; Yang J; Dai C
    J Am Soc Nephrol; 2013 Jun; 24(7):1114-26. PubMed ID: 23661807
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Mammalian target of rapamycin activator RHEB is frequently overexpressed in human carcinomas and is critical and sufficient for skin epithelial carcinogenesis.
    Lu ZH; Shvartsman MB; Lee AY; Shao JM; Murray MM; Kladney RD; Fan D; Krajewski S; Chiang GG; Mills GB; Arbeit JM
    Cancer Res; 2010 Apr; 70(8):3287-98. PubMed ID: 20388784
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Lovastatin induces VSMC differentiation through inhibition of Rheb and mTOR.
    Wagner RJ; Martin KA; Powell RJ; Rzucidlo EM
    Am J Physiol Cell Physiol; 2010 Jul; 299(1):C119-27. PubMed ID: 20375271
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Phospholipase D1 is an effector of Rheb in the mTOR pathway.
    Sun Y; Fang Y; Yoon MS; Zhang C; Roccio M; Zwartkruis FJ; Armstrong M; Brown HA; Chen J
    Proc Natl Acad Sci U S A; 2008 Jun; 105(24):8286-91. PubMed ID: 18550814
    [TBL] [Abstract][Full Text] [Related]  

  • 26. TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1.
    Dibble CC; Elis W; Menon S; Qin W; Klekota J; Asara JM; Finan PM; Kwiatkowski DJ; Murphy LO; Manning BD
    Mol Cell; 2012 Aug; 47(4):535-46. PubMed ID: 22795129
    [TBL] [Abstract][Full Text] [Related]  

  • 27. The TSC-mTOR pathway mediates translational activation of TOP mRNAs by insulin largely in a raptor- or rictor-independent manner.
    Patursky-Polischuk I; Stolovich-Rain M; Hausner-Hanochi M; Kasir J; Cybulski N; Avruch J; Rüegg MA; Hall MN; Meyuhas O
    Mol Cell Biol; 2009 Feb; 29(3):640-9. PubMed ID: 19047368
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Specific activation of mTORC1 by Rheb G-protein in vitro involves enhanced recruitment of its substrate protein.
    Sato T; Nakashima A; Guo L; Tamanoi F
    J Biol Chem; 2009 May; 284(19):12783-91. PubMed ID: 19299511
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Hepatitis C virus inhibits AKT-tuberous sclerosis complex (TSC), the mechanistic target of rapamycin (MTOR) pathway, through endoplasmic reticulum stress to induce autophagy.
    Huang H; Kang R; Wang J; Luo G; Yang W; Zhao Z
    Autophagy; 2013 Feb; 9(2):175-95. PubMed ID: 23169238
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Hypoxia-induced energy stress regulates mRNA translation and cell growth.
    Liu L; Cash TP; Jones RG; Keith B; Thompson CB; Simon MC
    Mol Cell; 2006 Feb; 21(4):521-31. PubMed ID: 16483933
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Intestinal cell kinase (ICK) promotes activation of mTOR complex 1 (mTORC1) through phosphorylation of Raptor Thr-908.
    Wu D; Chapman JR; Wang L; Harris TE; Shabanowitz J; Hunt DF; Fu Z
    J Biol Chem; 2012 Apr; 287(15):12510-9. PubMed ID: 22356909
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Characterization of the Rheb-mTOR signaling pathway in mammalian cells: constitutive active mutants of Rheb and mTOR.
    Sato T; Umetsu A; Tamanoi F
    Methods Enzymol; 2008; 438():307-20. PubMed ID: 18413257
    [TBL] [Abstract][Full Text] [Related]  

  • 33. REDD2 is enriched in skeletal muscle and inhibits mTOR signaling in response to leucine and stretch.
    Miyazaki M; Esser KA
    Am J Physiol Cell Physiol; 2009 Mar; 296(3):C583-92. PubMed ID: 19129461
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Aberrant Rheb-mediated mTORC1 activation and Pten haploinsufficiency are cooperative oncogenic events.
    Nardella C; Chen Z; Salmena L; Carracedo A; Alimonti A; Egia A; Carver B; Gerald W; Cordon-Cardo C; Pandolfi PP
    Genes Dev; 2008 Aug; 22(16):2172-7. PubMed ID: 18708577
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Non-canonical functions of the tuberous sclerosis complex-Rheb signalling axis.
    Neuman NA; Henske EP
    EMBO Mol Med; 2011 Apr; 3(4):189-200. PubMed ID: 21412983
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Proton-assisted amino acid transporter PAT1 complexes with Rag GTPases and activates TORC1 on late endosomal and lysosomal membranes.
    Ögmundsdóttir MH; Heublein S; Kazi S; Reynolds B; Visvalingam SM; Shaw MK; Goberdhan DC
    PLoS One; 2012; 7(5):e36616. PubMed ID: 22574197
    [TBL] [Abstract][Full Text] [Related]  

  • 37. The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1.
    Sancak Y; Peterson TR; Shaul YD; Lindquist RA; Thoreen CC; Bar-Peled L; Sabatini DM
    Science; 2008 Jun; 320(5882):1496-501. PubMed ID: 18497260
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Molecular mechanisms through which amino acids mediate signaling through the mammalian target of rapamycin.
    Kimball SR; Jefferson LS
    Curr Opin Clin Nutr Metab Care; 2004 Jan; 7(1):39-44. PubMed ID: 15090902
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Bnip3 mediates the hypoxia-induced inhibition on mammalian target of rapamycin by interacting with Rheb.
    Li Y; Wang Y; Kim E; Beemiller P; Wang CY; Swanson J; You M; Guan KL
    J Biol Chem; 2007 Dec; 282(49):35803-13. PubMed ID: 17928295
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner.
    Castro AF; Rebhun JF; Clark GJ; Quilliam LA
    J Biol Chem; 2003 Aug; 278(35):32493-6. PubMed ID: 12842888
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 17.