268 related articles for article (PubMed ID: 25176125)
1. SAR studies on carboxylic acid series M(1) selective positive allosteric modulators (PAMs).
Kuduk SD; Beshore DC
Curr Top Med Chem; 2014; 14(15):1738-54. PubMed ID: 25176125
[TBL] [Abstract][Full Text] [Related]
2. Novel M(1) allosteric ligands: a patent review.
Kuduk SD; Beshore DC
Expert Opin Ther Pat; 2012 Dec; 22(12):1385-98. PubMed ID: 23092292
[TBL] [Abstract][Full Text] [Related]
3. Probing the binding site of novel selective positive allosteric modulators at the M
Khajehali E; Valant C; Jörg M; Tobin AB; Conn PJ; Lindsley CW; Sexton PM; Scammells PJ; Christopoulos A
Biochem Pharmacol; 2018 Aug; 154():243-254. PubMed ID: 29777683
[TBL] [Abstract][Full Text] [Related]
4. Diverse Effects on M
Rook JM; Abe M; Cho HP; Nance KD; Luscombe VB; Adams JJ; Dickerson JW; Remke DH; Garcia-Barrantes PM; Engers DW; Engers JL; Chang S; Foster JJ; Blobaum AL; Niswender CM; Jones CK; Conn PJ; Lindsley CW
ACS Chem Neurosci; 2017 Apr; 8(4):866-883. PubMed ID: 28001356
[TBL] [Abstract][Full Text] [Related]
5. 4-Phenylpyridin-2-one Derivatives: A Novel Class of Positive Allosteric Modulator of the M1 Muscarinic Acetylcholine Receptor.
Mistry SN; Jörg M; Lim H; Vinh NB; Sexton PM; Capuano B; Christopoulos A; Lane JR; Scammells PJ
J Med Chem; 2016 Jan; 59(1):388-409. PubMed ID: 26624844
[TBL] [Abstract][Full Text] [Related]
6. M1 muscarinic acetylcholine receptors: A therapeutic strategy for symptomatic and disease-modifying effects in Alzheimer's disease?
Scarpa M; Hesse S; Bradley SJ
Adv Pharmacol; 2020; 88():277-310. PubMed ID: 32416870
[TBL] [Abstract][Full Text] [Related]
7. Discovery and SAR of muscarinic receptor subtype 1 (M1) allosteric activators from a molecular libraries high throughput screen. Part 1: 2,5-dibenzyl-2H-pyrazolo[4,3-c]quinolin-3(5H)-ones as positive allosteric modulators.
Han C; Chatterjee A; Noetzel MJ; Panarese JD; Smith E; Chase P; Hodder P; Niswender C; Conn PJ; Lindsley CW; Stauffer SR
Bioorg Med Chem Lett; 2015 Jan; 25(2):384-8. PubMed ID: 25435150
[TBL] [Abstract][Full Text] [Related]
8. Discovery of a selective allosteric M1 receptor modulator with suitable development properties based on a quinolizidinone carboxylic acid scaffold.
Kuduk SD; Chang RK; Di Marco CN; Pitts DR; Greshock TJ; Ma L; Wittmann M; Seager MA; Koeplinger KA; Thompson CD; Hartman GD; Bilodeau MT; Ray WJ
J Med Chem; 2011 Jul; 54(13):4773-80. PubMed ID: 21682298
[TBL] [Abstract][Full Text] [Related]
9. A selective allosteric potentiator of the M1 muscarinic acetylcholine receptor increases activity of medial prefrontal cortical neurons and restores impairments in reversal learning.
Shirey JK; Brady AE; Jones PJ; Davis AA; Bridges TM; Kennedy JP; Jadhav SB; Menon UN; Xiang Z; Watson ML; Christian EP; Doherty JJ; Quirk MC; Snyder DH; Lah JJ; Levey AI; Nicolle MM; Lindsley CW; Conn PJ
J Neurosci; 2009 Nov; 29(45):14271-86. PubMed ID: 19906975
[TBL] [Abstract][Full Text] [Related]
10. An Approach to Discovering Novel Muscarinic M
Kurimoto E; Matsuda S; Shimizu Y; Sako Y; Mandai T; Sugimoto T; Sakamoto H; Kimura H
J Pharmacol Exp Ther; 2018 Jan; 364(1):28-37. PubMed ID: 29025977
[TBL] [Abstract][Full Text] [Related]
11. Assessment of the Molecular Mechanisms of Action of Novel 4-Phenylpyridine-2-One and 6-Phenylpyrimidin-4-One Allosteric Modulators at the M
van der Westhuizen ET; Spathis A; Khajehali E; Jörg M; Mistry SN; Capuano B; Tobin AB; Sexton PM; Scammells PJ; Valant C; Christopoulos A
Mol Pharmacol; 2018 Jul; 94(1):770-783. PubMed ID: 29691279
[TBL] [Abstract][Full Text] [Related]
12. The pharmacologic characterization of allosteric molecules: Gq protein activation.
Bdioui S; Verdi J; Pierre N; Trinquet E; Roux T; Kenakin T
J Recept Signal Transduct Res; 2019 Apr; 39(2):106-113. PubMed ID: 31322035
[No Abstract] [Full Text] [Related]
13. Progress toward a high-affinity allosteric enhancer at muscarinic M1 receptors.
Lazareno S; Popham A; Birdsall NJ
J Mol Neurosci; 2003; 20(3):363-7. PubMed ID: 14501021
[TBL] [Abstract][Full Text] [Related]
14. Pharmacological characterization of LY593093, an M1 muscarinic acetylcholine receptor-selective partial orthosteric agonist.
Watt ML; Schober DA; Hitchcock S; Liu B; Chesterfield AK; McKinzie D; Felder CC
J Pharmacol Exp Ther; 2011 Aug; 338(2):622-32. PubMed ID: 21558436
[TBL] [Abstract][Full Text] [Related]
15. Selective activation of the M1 muscarinic acetylcholine receptor achieved by allosteric potentiation.
Ma L; Seager MA; Wittmann M; Jacobson M; Bickel D; Burno M; Jones K; Graufelds VK; Xu G; Pearson M; McCampbell A; Gaspar R; Shughrue P; Danziger A; Regan C; Flick R; Pascarella D; Garson S; Doran S; Kreatsoulas C; Veng L; Lindsley CW; Shipe W; Kuduk S; Sur C; Kinney G; Seabrook GR; Ray WJ
Proc Natl Acad Sci U S A; 2009 Sep; 106(37):15950-5. PubMed ID: 19717450
[TBL] [Abstract][Full Text] [Related]
16. Using cholinergic M1 receptor positive allosteric modulators to improve memory via enhancement of brain cholinergic communication.
Chambon C; Jatzke C; Wegener N; Gravius A; Danysz W
Eur J Pharmacol; 2012 Dec; 697(1-3):73-80. PubMed ID: 23085025
[TBL] [Abstract][Full Text] [Related]
17. Fused heterocyclic M1 positive allosteric modulators.
Kuduk SD; Di Marco CN; Cofre V; Ray WJ; Ma L; Wittmann M; Seager MA; Koeplinger KA; Thompson CD; Hartman GD; Bilodeau MT
Bioorg Med Chem Lett; 2011 May; 21(9):2769-72. PubMed ID: 21055928
[TBL] [Abstract][Full Text] [Related]
18. Bitopic Binding Mode of an M
Bradley SJ; Molloy C; Bundgaard C; Mogg AJ; Thompson KJ; Dwomoh L; Sanger HE; Crabtree MD; Brooke SM; Sexton PM; Felder CC; Christopoulos A; Broad LM; Tobin AB; Langmead CJ
Mol Pharmacol; 2018 Jun; 93(6):645-656. PubMed ID: 29695609
[TBL] [Abstract][Full Text] [Related]
19. Synthesis and pharmacological profiling of analogues of benzyl quinolone carboxylic acid (BQCA) as allosteric modulators of the M1 muscarinic receptor.
Mistry SN; Valant C; Sexton PM; Capuano B; Christopoulos A; Scammells PJ
J Med Chem; 2013 Jun; 56(12):5151-72. PubMed ID: 23718562
[TBL] [Abstract][Full Text] [Related]
20. Surface modified nano-lipid drug conjugates of positive allosteric modulators of M1 muscarinic acetylcholine receptor for the treatment of Alzheimer's disease.
Chintamaneni PK; Krishnamurthy PT; Rao PV; Pindiprolu SS
Med Hypotheses; 2017 Apr; 101():17-22. PubMed ID: 28351483
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]