539 related articles for article (PubMed ID: 25176435)
1. Opportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders.
Conn PJ; Lindsley CW; Meiler J; Niswender CM
Nat Rev Drug Discov; 2014 Sep; 13(9):692-708. PubMed ID: 25176435
[TBL] [Abstract][Full Text] [Related]
2. Strategies for the identification of allosteric modulators of G-protein-coupled receptors.
Burford NT; Watson J; Bertekap R; Alt A
Biochem Pharmacol; 2011 Mar; 81(6):691-702. PubMed ID: 21184747
[TBL] [Abstract][Full Text] [Related]
3. Development of allosteric modulators of GPCRs for treatment of CNS disorders.
Nickols HH; Conn PJ
Neurobiol Dis; 2014 Jan; 61():55-71. PubMed ID: 24076101
[TBL] [Abstract][Full Text] [Related]
4. Recent progress on the identification of metabotropic glutamate 4 receptor ligands and their potential utility as CNS therapeutics.
Robichaud AJ; Engers DW; Lindsley CW; Hopkins CR
ACS Chem Neurosci; 2011 Aug; 2(8):433-49. PubMed ID: 22860170
[TBL] [Abstract][Full Text] [Related]
5. Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders.
Conn PJ; Christopoulos A; Lindsley CW
Nat Rev Drug Discov; 2009 Jan; 8(1):41-54. PubMed ID: 19116626
[TBL] [Abstract][Full Text] [Related]
6. Recent advances in drug discovery of GPCR allosteric modulators for neurodegenerative disorders.
Lütjens R; Rocher JP
Curr Opin Pharmacol; 2017 Feb; 32():91-95. PubMed ID: 28135635
[TBL] [Abstract][Full Text] [Related]
7. Covalent allosteric modulation: An emerging strategy for GPCRs drug discovery.
Bian Y; Jun JJ; Cuyler J; Xie XQ
Eur J Med Chem; 2020 Nov; 206():112690. PubMed ID: 32818870
[TBL] [Abstract][Full Text] [Related]
8. Allosteric modulation of Class C GPCRs: a novel approach for the treatment of CNS disorders.
Engers DW; Lindsley CW
Drug Discov Today Technol; 2013; 10(2):e269-76. PubMed ID: 24050278
[TBL] [Abstract][Full Text] [Related]
9. Computational Advances for the Development of Allosteric Modulators and Bitopic Ligands in G Protein-Coupled Receptors.
Feng Z; Hu G; Ma S; Xie XQ
AAPS J; 2015 Sep; 17(5):1080-95. PubMed ID: 25940084
[TBL] [Abstract][Full Text] [Related]
10. Allosteric Modulators of the Class A G Protein Coupled Receptors.
Tschammer N
Adv Exp Med Biol; 2016; 917():185-207. PubMed ID: 27236557
[TBL] [Abstract][Full Text] [Related]
11. Allosteric Modulation of GPCRs: New Insights and Potential Utility for Treatment of Schizophrenia and Other CNS Disorders.
Foster DJ; Conn PJ
Neuron; 2017 May; 94(3):431-446. PubMed ID: 28472649
[TBL] [Abstract][Full Text] [Related]
12. Allosteric activators of muscarinic receptors as novel approaches for treatment of CNS disorders.
Digby GJ; Shirey JK; Conn PJ
Mol Biosyst; 2010 Aug; 6(8):1345-54. PubMed ID: 20582339
[TBL] [Abstract][Full Text] [Related]
13. Allosteric modulation of GPCRs: From structural insights to in silico drug discovery.
Persechino M; Hedderich JB; Kolb P; Hilger D
Pharmacol Ther; 2022 Sep; 237():108242. PubMed ID: 35863587
[TBL] [Abstract][Full Text] [Related]
14. Pharmacology of Free Fatty Acid Receptors and Their Allosteric Modulators.
Grundmann M; Bender E; Schamberger J; Eitner F
Int J Mol Sci; 2021 Feb; 22(4):. PubMed ID: 33578942
[TBL] [Abstract][Full Text] [Related]
15. Neurobiological insights and novel therapeutic opportunities for CNS disorders from mGlu receptor allosteric and biased modulation.
Hellyer S; Leach K; Gregory KJ
Curr Opin Pharmacol; 2017 Feb; 32():49-55. PubMed ID: 27842256
[TBL] [Abstract][Full Text] [Related]
16. Practical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate Receptors.
Lindsley CW; Emmitte KA; Hopkins CR; Bridges TM; Gregory KJ; Niswender CM; Conn PJ
Chem Rev; 2016 Jun; 116(11):6707-41. PubMed ID: 26882314
[TBL] [Abstract][Full Text] [Related]
17. Allosteric modulation of seven transmembrane spanning receptors: theory, practice, and opportunities for central nervous system drug discovery.
Melancon BJ; Hopkins CR; Wood MR; Emmitte KA; Niswender CM; Christopoulos A; Conn PJ; Lindsley CW
J Med Chem; 2012 Feb; 55(4):1445-64. PubMed ID: 22148748
[No Abstract] [Full Text] [Related]
18. Biased Allosteric Modulators: New Frontiers in GPCR Drug Discovery.
Slosky LM; Caron MG; Barak LS
Trends Pharmacol Sci; 2021 Apr; 42(4):283-299. PubMed ID: 33581873
[TBL] [Abstract][Full Text] [Related]
19. High-Throughput Screening for Allosteric Modulators of GPCRs.
Bertekap RL; Burford NT; Li Z; Alt A
Methods Mol Biol; 2015; 1335():223-40. PubMed ID: 26260604
[TBL] [Abstract][Full Text] [Related]
20. Overview of the use of transgenic animals in CNS drug discovery.
Nestler EJ; Olivier B
Curr Protoc Pharmacol; 2001 May; Chapter 5():Unit5.20. PubMed ID: 21965073
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]