BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

164 related articles for article (PubMed ID: 25179146)

  • 1. Domains for activation and inactivation in G protein-coupled receptors--a mutational analysis of constitutive activity of the adenosine A2B receptor.
    Peeters MC; Li Q; Elands R; van Westen GJ; Lenselink EB; Müller CE; IJzerman AP
    Biochem Pharmacol; 2014 Nov; 92(2):348-57. PubMed ID: 25179146
    [TBL] [Abstract][Full Text] [Related]  

  • 2. GPCR structure and activation: an essential role for the first extracellular loop in activating the adenosine A2B receptor.
    Peeters MC; van Westen GJ; Guo D; Wisse LE; Müller CE; Beukers MW; Ijzerman AP
    FASEB J; 2011 Feb; 25(2):632-43. PubMed ID: 21030693
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Scanning mutagenesis in a yeast system delineates the role of the NPxxY(x)(5,6)F motif and helix 8 of the adenosine A(2B) receptor in G protein coupling.
    Liu R; Nahon D; le Roy B; Lenselink EB; IJzerman AP
    Biochem Pharmacol; 2015 Jun; 95(4):290-300. PubMed ID: 25896847
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The second extracellular loop of GPCRs determines subtype-selectivity and controls efficacy as evidenced by loop exchange study at A2 adenosine receptors.
    Seibt BF; Schiedel AC; Thimm D; Hinz S; Sherbiny FF; Müller CE
    Biochem Pharmacol; 2013 May; 85(9):1317-29. PubMed ID: 23500543
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Random mutagenesis of the human adenosine A2B receptor followed by growth selection in yeast. Identification of constitutively active and gain of function mutations.
    Beukers MW; van Oppenraaij J; van der Hoorn PP; Blad CC; den Dulk H; Brouwer J; IJzerman AP
    Mol Pharmacol; 2004 Mar; 65(3):702-10. PubMed ID: 14978249
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Three "hotspots" important for adenosine A(2B) receptor activation: a mutational analysis of transmembrane domains 4 and 5 and the second extracellular loop.
    Peeters MC; Li Q; van Westen GJ; Ijzerman AP
    Purinergic Signal; 2012 Mar; 8(1):23-38. PubMed ID: 21818573
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Characterization of cancer-related somatic mutations in the adenosine A
    Wang X; Jespers W; Bongers BJ; Habben Jansen MCC; Stangenberger CM; Dilweg MA; Gutiérrez-de-Terán H; IJzerman AP; Heitman LH; van Westen GJP
    Eur J Pharmacol; 2020 Aug; 880():173126. PubMed ID: 32348778
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Constitutive activity of bitter taste receptors (T2Rs).
    Pydi SP; Bhullar RP; Chelikani P
    Adv Pharmacol; 2014; 70():303-26. PubMed ID: 24931200
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Identification of residues that contribute to receptor activation through the analysis of compensatory mutations in the G protein-coupled alpha-factor receptor.
    Lin JC; Duell K; Saracino M; Konopka JB
    Biochemistry; 2005 Feb; 44(4):1278-87. PubMed ID: 15667221
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Molecular dynamics simulations reveal insights into key structural elements of adenosine receptors.
    Rodríguez D; Piñeiro Á; Gutiérrez-de-Terán H
    Biochemistry; 2011 May; 50(19):4194-208. PubMed ID: 21480628
    [TBL] [Abstract][Full Text] [Related]  

  • 11. A yeast screening method to decipher the interaction between the adenosine A2B receptor and the C-terminus of different G protein α-subunits.
    Liu R; Groenewoud NJ; Peeters MC; Lenselink EB; IJzerman AP
    Purinergic Signal; 2014 Sep; 10(3):441-53. PubMed ID: 24464644
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Ligand-specific binding and activation of the human adenosine A(2B) receptor.
    Thimm D; Schiedel AC; Sherbiny FF; Hinz S; Hochheiser K; Bertarelli DC; Maass A; Müller CE
    Biochemistry; 2013 Jan; 52(4):726-40. PubMed ID: 23286920
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The four cysteine residues in the second extracellular loop of the human adenosine A2B receptor: role in ligand binding and receptor function.
    Schiedel AC; Hinz S; Thimm D; Sherbiny F; Borrmann T; Maass A; Müller CE
    Biochem Pharmacol; 2011 Aug; 82(4):389-99. PubMed ID: 21620804
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The role of the second and third extracellular loops of the adenosine A1 receptor in activation and allosteric modulation.
    Peeters MC; Wisse LE; Dinaj A; Vroling B; Vriend G; Ijzerman AP
    Biochem Pharmacol; 2012 Jul; 84(1):76-87. PubMed ID: 22449615
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Expression and biophysical analysis of two double-transmembrane domain-containing fragments from a yeast G protein-coupled receptor.
    Cohen LS; Arshava B; Estephan R; Englander J; Kim H; Hauser M; Zerbe O; Ceruso M; Becker JM; Naider F
    Biopolymers; 2008; 90(2):117-30. PubMed ID: 18260136
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Identification of amino acids at two dimer interface regions of the alpha-factor receptor (Ste2).
    Wang HX; Konopka JB
    Biochemistry; 2009 Aug; 48(30):7132-9. PubMed ID: 19588927
    [TBL] [Abstract][Full Text] [Related]  

  • 17. ZM241385, DPCPX, MRS1706 are inverse agonists with different relative intrinsic efficacies on constitutively active mutants of the human adenosine A2B receptor.
    Li Q; Ye K; Blad CC; den Dulk H; Brouwer J; Ijzerman AP; Beukers MW
    J Pharmacol Exp Ther; 2007 Feb; 320(2):637-45. PubMed ID: 17077318
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Molecular mechanisms of ligand binding, signaling, and regulation within the superfamily of G-protein-coupled receptors: molecular modeling and mutagenesis approaches to receptor structure and function.
    Kristiansen K
    Pharmacol Ther; 2004 Jul; 103(1):21-80. PubMed ID: 15251227
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Changes in conformation at the cytoplasmic ends of the fifth and sixth transmembrane helices of a yeast G protein-coupled receptor in response to ligand binding.
    Umanah GK; Huang LY; Maccarone JM; Naider F; Becker JM
    Biochemistry; 2011 Aug; 50(32):6841-54. PubMed ID: 21728340
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Agonist-induced conformational changes in bovine rhodopsin: insight into activation of G-protein-coupled receptors.
    Bhattacharya S; Hall SE; Vaidehi N
    J Mol Biol; 2008 Oct; 382(2):539-55. PubMed ID: 18638482
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.