BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

292 related articles for article (PubMed ID: 25197067)

  • 1. Human oxygen sensing may have origins in prokaryotic elongation factor Tu prolyl-hydroxylation.
    Scotti JS; Leung IK; Ge W; Bentley MA; Paps J; Kramer HB; Lee J; Aik W; Choi H; Paulsen SM; Bowman LA; Loik ND; Horita S; Ho CH; Kershaw NJ; Tang CM; Claridge TD; Preston GM; McDonough MA; Schofield CJ
    Proc Natl Acad Sci U S A; 2014 Sep; 111(37):13331-6. PubMed ID: 25197067
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Bacillus anthracis Prolyl 4-Hydroxylase Interacts with and Modifies Elongation Factor Tu.
    Schnicker NJ; Razzaghi M; Guha Thakurta S; Chakravarthy S; Dey M
    Biochemistry; 2017 Oct; 56(43):5771-5785. PubMed ID: 28981257
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Pseudomonas expression of an oxygen sensing prolyl hydroxylase homologue regulates neutrophil host responses
    Dickinson RS; Murphy F; Doherty C; Williams S; Mirchandani A; Willson J; Scotti JS; Preston G; Schofield CJ; Whyte MKB; Walmsley SR
    Wellcome Open Res; 2017; 2():104. PubMed ID: 29387803
    [No Abstract]   [Full Text] [Related]  

  • 4. Structural basis for binding of the renal carcinoma target hypoxia-inducible factor 2α to prolyl hydroxylase domain 2.
    Figg WD; Fiorini G; Chowdhury R; Nakashima Y; Tumber A; McDonough MA; Schofield CJ
    Proteins; 2023 Nov; 91(11):1510-1524. PubMed ID: 37449559
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases.
    Chowdhury R; McDonough MA; Mecinović J; Loenarz C; Flashman E; Hewitson KS; Domene C; Schofield CJ
    Structure; 2009 Jul; 17(7):981-9. PubMed ID: 19604478
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Substrate preference of the HIF-prolyl hydroxylase-2 (PHD2) and substrate-induced conformational change.
    Pektas S; Knapp MJ
    J Inorg Biochem; 2013 Sep; 126():55-60. PubMed ID: 23787140
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Biochemical and biophysical analyses of hypoxia sensing prolyl hydroxylases from
    Liu T; Abboud MI; Chowdhury R; Tumber A; Hardy AP; Lippl K; Lohans CT; Pires E; Wickens J; McDonough MA; West CM; Schofield CJ
    J Biol Chem; 2020 Dec; 295(49):16545-16561. PubMed ID: 32934009
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates.
    Cockman ME; Lippl K; Tian YM; Pegg HB; Figg WD; Abboud MI; Heilig R; Fischer R; Myllyharju J; Schofield CJ; Ratcliffe PJ
    Elife; 2019 Sep; 8():. PubMed ID: 31500697
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Studies on the Substrate Selectivity of the Hypoxia-Inducible Factor Prolyl Hydroxylase 2 Catalytic Domain.
    Abboud MI; Chowdhury R; Leung IKH; Lippl K; Loenarz C; Claridge TDW; Schofield CJ
    Chembiochem; 2018 Nov; 19(21):2262-2267. PubMed ID: 30144273
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.
    Chowdhury R; Leung IK; Tian YM; Abboud MI; Ge W; Domene C; Cantrelle FX; Landrieu I; Hardy AP; Pugh CW; Ratcliffe PJ; Claridge TD; Schofield CJ
    Nat Commun; 2016 Aug; 7():12673. PubMed ID: 27561929
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Investigating the contribution of the active site environment to the slow reaction of hypoxia-inducible factor prolyl hydroxylase domain 2 with oxygen.
    Tarhonskaya H; Chowdhury R; Leung IK; Loik ND; McCullagh JS; Claridge TD; Schofield CJ; Flashman E
    Biochem J; 2014 Nov; 463(3):363-72. PubMed ID: 25120187
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Protein Hydroxylation by Hypoxia-Inducible Factor (HIF) Hydroxylases: Unique or Ubiquitous?
    Strowitzki MJ; Cummins EP; Taylor CT
    Cells; 2019 Apr; 8(5):. PubMed ID: 31035491
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Molecular characterization and mRNA expression of HIF-prolyl hydroxylase-2 (phd2) in hypoxia-sensing pathways from Megalobrama amblycephala.
    Wang H; Huang C; Chen N; Zhu K; Chen B; Wang W; Wang H
    Comp Biochem Physiol B Biochem Mol Biol; 2015 Aug; 186():28-35. PubMed ID: 25868626
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Inhibition of the Oxygen-Sensing Asparaginyl Hydroxylase Factor Inhibiting Hypoxia-Inducible Factor: A Potential Hypoxia Response Modulating Strategy.
    Wu Y; Li Z; McDonough MA; Schofield CJ; Zhang X
    J Med Chem; 2021 Jun; 64(11):7189-7209. PubMed ID: 34029087
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The non-canonical functions of HIF prolyl hydroxylases and their dual roles in cancer.
    Yu M; Lun J; Zhang H; Zhu L; Zhang G; Fang J
    Int J Biochem Cell Biol; 2021 Jun; 135():105982. PubMed ID: 33894356
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Kinetic rationale for selectivity toward N- and C-terminal oxygen-dependent degradation domain substrates mediated by a loop region of hypoxia-inducible factor prolyl hydroxylases.
    Flashman E; Bagg EA; Chowdhury R; Mecinović J; Loenarz C; McDonough MA; Hewitson KS; Schofield CJ
    J Biol Chem; 2008 Feb; 283(7):3808-15. PubMed ID: 18063574
    [TBL] [Abstract][Full Text] [Related]  

  • 17. 2-Oxoglutarate regulates binding of hydroxylated hypoxia-inducible factor to prolyl hydroxylase domain 2.
    Abboud MI; McAllister TE; Leung IKH; Chowdhury R; Jorgensen C; Domene C; Mecinović J; Lippl K; Hancock RL; Hopkinson RJ; Kawamura A; Claridge TDW; Schofield CJ
    Chem Commun (Camb); 2018 Mar; 54(25):3130-3133. PubMed ID: 29522057
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases.
    Koivunen P; Hirsilä M; Günzler V; Kivirikko KI; Myllyharju J
    J Biol Chem; 2004 Mar; 279(11):9899-904. PubMed ID: 14701857
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Inhibition of a viral prolyl hydroxylase.
    Langley GW; Abboud MI; Lohans CT; Schofield CJ
    Bioorg Med Chem; 2019 Jun; 27(12):2405-2412. PubMed ID: 30737136
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Complement C1q is hydroxylated by collagen prolyl 4 hydroxylase and is sensitive to off-target inhibition by prolyl hydroxylase domain inhibitors that stabilize hypoxia-inducible factor.
    Kiriakidis S; Hoer SS; Burrows N; Biddlecome G; Khan MN; Thinnes CC; Schofield CJ; Rogers N; Botto M; Paleolog E; Maxwell PH
    Kidney Int; 2017 Oct; 92(4):900-908. PubMed ID: 28506759
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.