These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
2. Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1). Pearce LR; Alton GR; Richter DT; Kath JC; Lingardo L; Chapman J; Hwang C; Alessi DR Biochem J; 2010 Oct; 431(2):245-55. PubMed ID: 20704563 [TBL] [Abstract][Full Text] [Related]
3. Inhibition of mitochondrial complex 1 by the S6K1 inhibitor PF-4708671 partly contributes to its glucose metabolic effects in muscle and liver cells. Shum M; Houde VP; Bellemare V; Junges Moreira R; Bellmann K; St-Pierre P; Viollet B; Foretz M; Marette A J Biol Chem; 2019 Aug; 294(32):12250-12260. PubMed ID: 31243102 [TBL] [Abstract][Full Text] [Related]
4. Role of AMP-activated protein kinase activators in antiproliferative multi-drug pituitary tumour therapies: effects of combined treatments with compounds affecting the mTOR-p70S6 kinase axis in cultured pituitary tumour cells. Tulipano G; Faggi L; Cacciamali A; Spinello M; Cocchi D; Giustina A J Neuroendocrinol; 2015 Jan; 27(1):20-32. PubMed ID: 25323047 [TBL] [Abstract][Full Text] [Related]
5. mTORC1-S6K1 inhibition or mTORC2 activation improves hippocampal synaptic plasticity and learning in Angelman syndrome mice. Sun J; Liu Y; Tran J; O'Neal P; Baudry M; Bi X Cell Mol Life Sci; 2016 Nov; 73(22):4303-4314. PubMed ID: 27173058 [TBL] [Abstract][Full Text] [Related]
6. Ciclopirox olamine inhibits mTORC1 signaling by activation of AMPK. Zhou H; Shang C; Wang M; Shen T; Kong L; Yu C; Ye Z; Luo Y; Liu L; Li Y; Huang S Biochem Pharmacol; 2016 Sep; 116():39-50. PubMed ID: 27396756 [TBL] [Abstract][Full Text] [Related]
7. Role of p70S6K1-mediated phosphorylation of eIF4B and PDCD4 proteins in the regulation of protein synthesis. Dennis MD; Jefferson LS; Kimball SR J Biol Chem; 2012 Dec; 287(51):42890-9. PubMed ID: 23105104 [TBL] [Abstract][Full Text] [Related]
8. Mechanistic target of rapamycin complex 1 (mTORC1)-mediated phosphorylation is governed by competition between substrates for interaction with raptor. Dennis MD; Kimball SR; Jefferson LS J Biol Chem; 2013 Jan; 288(1):10-9. PubMed ID: 23184952 [TBL] [Abstract][Full Text] [Related]
9. The lipid peroxidation product 4-hydroxy-trans-2-nonenal causes protein synthesis in cardiac myocytes via activated mTORC1-p70S6K-RPS6 signaling. Calamaras TD; Lee C; Lan F; Ido Y; Siwik DA; Colucci WS Free Radic Biol Med; 2015 May; 82():137-46. PubMed ID: 25617592 [TBL] [Abstract][Full Text] [Related]
10. Resistin promotes cardiac hypertrophy via the AMP-activated protein kinase/mammalian target of rapamycin (AMPK/mTOR) and c-Jun N-terminal kinase/insulin receptor substrate 1 (JNK/IRS1) pathways. Kang S; Chemaly ER; Hajjar RJ; Lebeche D J Biol Chem; 2011 May; 286(21):18465-73. PubMed ID: 21478152 [TBL] [Abstract][Full Text] [Related]
11. AMPD1 regulates mTORC1-p70 S6 kinase axis in the control of insulin sensitivity in skeletal muscle. Tandelilin AA; Hirase T; Hudoyo AW; Cheng J; Toyama K; Morisaki H; Morisaki T BMC Endocr Disord; 2015 Mar; 15():11. PubMed ID: 25887856 [TBL] [Abstract][Full Text] [Related]
12. Pharmacological inhibition of S6K1 increases glucose metabolism and Akt signalling in vitro and in diet-induced obese mice. Shum M; Bellmann K; St-Pierre P; Marette A Diabetologia; 2016 Mar; 59(3):592-603. PubMed ID: 26733005 [TBL] [Abstract][Full Text] [Related]
13. RhoA modulates signaling through the mechanistic target of rapamycin complex 1 (mTORC1) in mammalian cells. Gordon BS; Kazi AA; Coleman CS; Dennis MD; Chau V; Jefferson LS; Kimball SR Cell Signal; 2014 Mar; 26(3):461-7. PubMed ID: 24316235 [TBL] [Abstract][Full Text] [Related]
14. CCL2 is a negative regulator of AMP-activated protein kinase to sustain mTOR complex-1 activation, survivin expression, and cell survival in human prostate cancer PC3 cells. Roca H; Varsos ZS; Pienta KJ Neoplasia; 2009 Dec; 11(12):1309-17. PubMed ID: 20019839 [TBL] [Abstract][Full Text] [Related]
15. DIF-1 inhibits growth and metastasis of triple-negative breast cancer through AMPK-mediated inhibition of the mTORC1-S6K signaling pathway. Seto-Tetsuo F; Arioka M; Miura K; Inoue T; Igawa K; Tomooka K; Takahashi-Yanaga F; Sasaguri T Oncogene; 2021 Sep; 40(37):5579-5589. PubMed ID: 34304250 [TBL] [Abstract][Full Text] [Related]
16. p70 S6K1 nuclear localization depends on its mTOR-mediated phosphorylation at T389, but not on its kinase activity towards S6. Rosner M; Schipany K; Hengstschläger M Amino Acids; 2012 Jun; 42(6):2251-6. PubMed ID: 21710263 [TBL] [Abstract][Full Text] [Related]
17. Phosphorylation of IRS1 at serine 307 in response to insulin in human adipocytes is not likely to be catalyzed by p70 ribosomal S6 kinase. Rajan MR; Fagerholm S; Jönsson C; Kjølhede P; Turkina MV; Strålfors P PLoS One; 2013; 8(4):e59725. PubMed ID: 23565163 [TBL] [Abstract][Full Text] [Related]
18. Sestrins inhibit mTORC1 kinase activation through the GATOR complex. Parmigiani A; Nourbakhsh A; Ding B; Wang W; Kim YC; Akopiants K; Guan KL; Karin M; Budanov AV Cell Rep; 2014 Nov; 9(4):1281-91. PubMed ID: 25457612 [TBL] [Abstract][Full Text] [Related]
19. A possible linkage between AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway. Kimura N; Tokunaga C; Dalal S; Richardson C; Yoshino K; Hara K; Kemp BE; Witters LA; Mimura O; Yonezawa K Genes Cells; 2003 Jan; 8(1):65-79. PubMed ID: 12558800 [TBL] [Abstract][Full Text] [Related]
20. mTORC1 and JNK coordinate phosphorylation of the p70S6K1 autoinhibitory domain in skeletal muscle following functional overloading. Martin TD; Dennis MD; Gordon BS; Kimball SR; Jefferson LS Am J Physiol Endocrinol Metab; 2014 Jun; 306(12):E1397-405. PubMed ID: 24801387 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]