170 related articles for article (PubMed ID: 25208557)
1. Molecular simulation of Tyr105 phosphorylated pyruvate kinase M2 to understand its structure and dynamics.
Kalaiarasan P; Subbarao N; Bamezai RN
J Mol Model; 2014 Sep; 20(9):2447. PubMed ID: 25208557
[TBL] [Abstract][Full Text] [Related]
2. Synergistic Allosteric Mechanism of Fructose-1,6-bisphosphate and Serine for Pyruvate Kinase M2 via Dynamics Fluctuation Network Analysis.
Yang J; Liu H; Liu X; Gu C; Luo R; Chen HF
J Chem Inf Model; 2016 Jun; 56(6):1184-1192. PubMed ID: 27227511
[TBL] [Abstract][Full Text] [Related]
3. Structural insight into mechanisms for dynamic regulation of PKM2.
Wang P; Sun C; Zhu T; Xu Y
Protein Cell; 2015 Apr; 6(4):275-287. PubMed ID: 25645022
[TBL] [Abstract][Full Text] [Related]
4. Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth.
Hitosugi T; Kang S; Vander Heiden MG; Chung TW; Elf S; Lythgoe K; Dong S; Lonial S; Wang X; Chen GZ; Xie J; Gu TL; Polakiewicz RD; Roesel JL; Boggon TJ; Khuri FR; Gilliland DG; Cantley LC; Kaufman J; Chen J
Sci Signal; 2009 Nov; 2(97):ra73. PubMed ID: 19920251
[TBL] [Abstract][Full Text] [Related]
5. Structural basis for allosteric regulation of pyruvate kinase M2 by phosphorylation and acetylation.
Nandi S; Razzaghi M; Srivastava D; Dey M
J Biol Chem; 2020 Dec; 295(51):17425-17440. PubMed ID: 33453989
[TBL] [Abstract][Full Text] [Related]
6. In silico screening, genotyping, molecular dynamics simulation and activity studies of SNPs in pyruvate kinase M2.
Kalaiarasan P; Kumar B; Chopra R; Gupta V; Subbarao N; Bamezai RN
PLoS One; 2015; 10(3):e0120469. PubMed ID: 25768091
[TBL] [Abstract][Full Text] [Related]
7. Native Mass Spectrometry Gives Insight into the Allosteric Binding Mechanism of M2 Pyruvate Kinase to Fructose-1,6-Bisphosphate.
Gavriilidou AFM; Holding FP; Mayer D; Coyle JE; Veprintsev DB; Zenobi R
Biochemistry; 2018 Mar; 57(11):1685-1689. PubMed ID: 29499117
[TBL] [Abstract][Full Text] [Related]
8. Reciprocal regulation of protein kinase and pyruvate kinase activities of pyruvate kinase M2 by growth signals.
Gao X; Wang H; Yang JJ; Chen J; Jie J; Li L; Zhang Y; Liu ZR
J Biol Chem; 2013 May; 288(22):15971-9. PubMed ID: 23576436
[TBL] [Abstract][Full Text] [Related]
9. Oncogenic Kinase-Induced PKM2 Tyrosine 105 Phosphorylation Converts Nononcogenic PKM2 to a Tumor Promoter and Induces Cancer Stem-like Cells.
Zhou Z; Li M; Zhang L; Zhao H; Şahin Ö; Chen J; Zhao JJ; Songyang Z; Yu D
Cancer Res; 2018 May; 78(9):2248-2261. PubMed ID: 29440169
[TBL] [Abstract][Full Text] [Related]
10. Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis.
Dombrauckas JD; Santarsiero BD; Mesecar AD
Biochemistry; 2005 Jul; 44(27):9417-29. PubMed ID: 15996096
[TBL] [Abstract][Full Text] [Related]
11. 2'-hydroxycinnamaldehyde inhibits cancer cell proliferation and tumor growth by targeting the pyruvate kinase M2.
Yoon YJ; Kim YH; Jin Y; Chi SW; Moon JH; Han DC; Kwon BM
Cancer Lett; 2018 Oct; 434():42-55. PubMed ID: 30009856
[TBL] [Abstract][Full Text] [Related]
12. Interaction of non-phosphorylated liver pyruvate kinase with fructose 1,6-bisphosphate and peptides that mimic the phosphorylatable N-terminus of the enzyme.
Faustova I; Järv J
Protein Pept Lett; 2013 Nov; 20(11):1200-3. PubMed ID: 23713905
[TBL] [Abstract][Full Text] [Related]
13. Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.
Anastasiou D; Yu Y; Israelsen WJ; Jiang JK; Boxer MB; Hong BS; Tempel W; Dimov S; Shen M; Jha A; Yang H; Mattaini KR; Metallo CM; Fiske BP; Courtney KD; Malstrom S; Khan TM; Kung C; Skoumbourdis AP; Veith H; Southall N; Walsh MJ; Brimacombe KR; Leister W; Lunt SY; Johnson ZR; Yen KE; Kunii K; Davidson SM; Christofk HR; Austin CP; Inglese J; Harris MH; Asara JM; Stephanopoulos G; Salituro FG; Jin S; Dang L; Auld DS; Park HW; Cantley LC; Thomas CJ; Vander Heiden MG
Nat Chem Biol; 2012 Oct; 8(10):839-47. PubMed ID: 22922757
[TBL] [Abstract][Full Text] [Related]
14. Molecular association of glucose-6-phosphate isomerase and pyruvate kinase M2 with glyceraldehyde-3-phosphate dehydrogenase in cancer cells.
Das MR; Bag AK; Saha S; Ghosh A; Dey SK; Das P; Mandal C; Ray S; Chakrabarti S; Ray M; Jana SS
BMC Cancer; 2016 Feb; 16():152. PubMed ID: 26911935
[TBL] [Abstract][Full Text] [Related]
15. Proviral insertion in murine lymphomas 2 (PIM2) oncogene phosphorylates pyruvate kinase M2 (PKM2) and promotes glycolysis in cancer cells.
Yu Z; Zhao X; Huang L; Zhang T; Yang F; Xie L; Song S; Miao P; Zhao L; Sun X; Liu J; Huang G
J Biol Chem; 2013 Dec; 288(49):35406-16. PubMed ID: 24142698
[TBL] [Abstract][Full Text] [Related]
16. OSU-A9 induced-reactive oxygen species cause cytotoxicity in duodenal and gastric cancer cells by decreasing phosphorylated nuclear pyruvate kinase M2 protein levels.
Chiu CF; Weng JR; Lee SL; Wu CY; Chu PC; Shan YS; Yang HR; Bai LY
Biochem Pharmacol; 2020 Apr; 174():113811. PubMed ID: 31954719
[TBL] [Abstract][Full Text] [Related]
17. PKM2 tyrosine phosphorylation and glutamine metabolism signal a different view of the Warburg effect.
Dang CV
Sci Signal; 2009 Nov; 2(97):pe75. PubMed ID: 19920249
[TBL] [Abstract][Full Text] [Related]
18. The allosteric regulation of pyruvate kinase by fructose-1,6-bisphosphate.
Jurica MS; Mesecar A; Heath PJ; Shi W; Nowak T; Stoddard BL
Structure; 1998 Feb; 6(2):195-210. PubMed ID: 9519410
[TBL] [Abstract][Full Text] [Related]
19. Roadmap to Pyruvate Kinase M2 Modulation - A Computational Chronicle.
Kapoor S; Chatterjee DR; Chowdhury MG; Das R; Shard A
Curr Drug Targets; 2023; 24(6):464-483. PubMed ID: 36998144
[TBL] [Abstract][Full Text] [Related]
20. Insulin enhances metabolic capacities of cancer cells by dual regulation of glycolytic enzyme pyruvate kinase M2.
Iqbal MA; Siddiqui FA; Gupta V; Chattopadhyay S; Gopinath P; Kumar B; Manvati S; Chaman N; Bamezai RN
Mol Cancer; 2013 Jul; 12():72. PubMed ID: 23837608
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
