223 related articles for article (PubMed ID: 25210872)
1. Development of inhibitors of the 2C-methyl-D-erythritol 4-phosphate (MEP) pathway enzymes as potential anti-infective agents.
Masini T; Hirsch AK
J Med Chem; 2014 Dec; 57(23):9740-63. PubMed ID: 25210872
[TBL] [Abstract][Full Text] [Related]
2. Methylerythritol phosphate pathway to isoprenoids: kinetic modeling and in silico enzyme inhibitions in Plasmodium falciparum.
Singh VK; Ghosh I
FEBS Lett; 2013 Sep; 587(17):2806-17. PubMed ID: 23816706
[TBL] [Abstract][Full Text] [Related]
3. Nonmevalonate terpene biosynthesis enzymes as antiinfective drug targets: substrate synthesis and high-throughput screening methods.
Illarionova V; Kaiser J; Ostrozhenkova E; Bacher A; Fischer M; Eisenreich W; Rohdich F
J Org Chem; 2006 Nov; 71(23):8824-34. PubMed ID: 17081012
[TBL] [Abstract][Full Text] [Related]
4. Targeting the methyl erythritol phosphate (MEP) pathway for novel antimalarial, antibacterial and herbicidal drug discovery: inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR) enzyme.
Singh N; Chevé G; Avery MA; McCurdy CR
Curr Pharm Des; 2007; 13(11):1161-77. PubMed ID: 17430177
[TBL] [Abstract][Full Text] [Related]
5. Non-mevalonate isoprenoid biosynthesis: enzymes, genes and inhibitors.
Lichtenthaler HK
Biochem Soc Trans; 2000 Dec; 28(6):785-9. PubMed ID: 11171208
[TBL] [Abstract][Full Text] [Related]
6. Synthesis and Evaluation of Fluoroalkyl Phosphonyl Analogues of 2- C-Methylerythritol Phosphate as Substrates and Inhibitors of IspD from Human Pathogens.
Bartee D; Wheadon MJ; Freel Meyers CL
J Org Chem; 2018 Sep; 83(17):9580-9591. PubMed ID: 29870251
[TBL] [Abstract][Full Text] [Related]
7. The methylerythritol phosphate (MEP) pathway for isoprenoid biosynthesis as a target for the development of new drugs against tuberculosis.
Obiol-Pardo C; Rubio-Martinez J; Imperial S
Curr Med Chem; 2011; 18(9):1325-38. PubMed ID: 21366531
[TBL] [Abstract][Full Text] [Related]
8. Escherichia coli engineered to synthesize isopentenyl diphosphate and dimethylallyl diphosphate from mevalonate: a novel system for the genetic analysis of the 2-C-methyl-d-erythritol 4-phosphate pathway for isoprenoid biosynthesis.
Campos N; Rodríguez-Concepción M; Sauret-Güeto S; Gallego F; Lois LM; Boronat A
Biochem J; 2001 Jan; 353(Pt 1):59-67. PubMed ID: 11115399
[TBL] [Abstract][Full Text] [Related]
9. Crystal structure of IspF from
Liu Z; Jin Y; Liu W; Tao Y; Wang G
Biosci Rep; 2018 Feb; 38(1):. PubMed ID: 29335298
[TBL] [Abstract][Full Text] [Related]
10. Isoprenoid biosynthesis via the methylerythritol phosphate pathway: structural variations around phosphonate anchor and spacer of fosmidomycin, a potent inhibitor of deoxyxylulose phosphate reductoisomerase.
Zinglé C; Kuntz L; Tritsch D; Grosdemange-Billiard C; Rohmer M
J Org Chem; 2010 May; 75(10):3203-7. PubMed ID: 20429517
[TBL] [Abstract][Full Text] [Related]
11. Anti-malarial drug targets: screening for inhibitors of 2C-methyl-D-erythritol 4-phosphate synthase (IspC protein) in Mediterranean plants.
Kaiser J; Yassin M; Prakash S; Safi N; Agami M; Lauw S; Ostrozhenkova E; Bacher A; Rohdich F; Eisenreich W; Safi J; Golan-Goldhirsh A
Phytomedicine; 2007 Apr; 14(4):242-9. PubMed ID: 17293098
[TBL] [Abstract][Full Text] [Related]
12. 2C-Methyl-d-erythritol 4-phosphate enhances and sustains cyclodiphosphate synthase IspF activity.
Bitok JK; Meyers CF
ACS Chem Biol; 2012 Oct; 7(10):1702-10. PubMed ID: 22839733
[TBL] [Abstract][Full Text] [Related]
13. Co-expression of three MEP pathway genes and geraniol 10-hydroxylase in internal phloem parenchyma of Catharanthus roseus implicates multicellular translocation of intermediates during the biosynthesis of monoterpene indole alkaloids and isoprenoid-derived primary metabolites.
Burlat V; Oudin A; Courtois M; Rideau M; St-Pierre B
Plant J; 2004 Apr; 38(1):131-41. PubMed ID: 15053766
[TBL] [Abstract][Full Text] [Related]
14. The methylerythritol phosphate pathway and its significance as a novel drug target.
Testa CA; Brown MJ
Curr Pharm Biotechnol; 2003 Aug; 4(4):248-59. PubMed ID: 14529427
[TBL] [Abstract][Full Text] [Related]
15. The MEP pathway: a new target for the development of herbicides, antibiotics and antimalarial drugs.
Rodríguez-Concepción M
Curr Pharm Des; 2004; 10(19):2391-400. PubMed ID: 15279616
[TBL] [Abstract][Full Text] [Related]
16. Synthesis and analysis of a fluorinated product analogue as an inhibitor for 1-deoxy-D-xylulose 5-phosphate reductoisomerase.
Munos JW; Pu X; Liu HW
Bioorg Med Chem Lett; 2008 May; 18(10):3090-4. PubMed ID: 18078746
[TBL] [Abstract][Full Text] [Related]
17. 1-Deoxy-D-xylulose 5-phosphate reductoisomerase: an overview.
Proteau PJ
Bioorg Chem; 2004 Dec; 32(6):483-93. PubMed ID: 15530989
[TBL] [Abstract][Full Text] [Related]
18. 1-Deoxy-D-xylulose 5-phosphate reductoisomerase (IspC) from Mycobacterium tuberculosis: towards understanding mycobacterial resistance to fosmidomycin.
Dhiman RK; Schaeffer ML; Bailey AM; Testa CA; Scherman H; Crick DC
J Bacteriol; 2005 Dec; 187(24):8395-402. PubMed ID: 16321944
[TBL] [Abstract][Full Text] [Related]
19. The herbicide ketoclomazone inhibits 1-deoxy-D-xylulose 5-phosphate synthase in the 2-C-methyl-D-erythritol 4-phosphate pathway and shows antibacterial activity against Haemophilus influenzae.
Matsue Y; Mizuno H; Tomita T; Asami T; Nishiyama M; Kuzuyama T
J Antibiot (Tokyo); 2010 Oct; 63(10):583-8. PubMed ID: 20808315
[TBL] [Abstract][Full Text] [Related]
20. Structural studies on Mycobacterium tuberculosis DXR in complex with the antibiotic FR-900098.
Björkelid C; Bergfors T; Unge T; Mowbray SL; Jones TA
Acta Crystallogr D Biol Crystallogr; 2012 Feb; 68(Pt 2):134-43. PubMed ID: 22281742
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]