BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

335 related articles for article (PubMed ID: 25213441)

  • 1. ATP puts the brake on DNA double-strand break repair: a new study shows that ATP switches the Mre11-Rad50-Nbs1 repair factor between signaling and processing of DNA ends.
    Hopfner KP
    Bioessays; 2014 Dec; 36(12):1170-8. PubMed ID: 25213441
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the Mre11/Rad50/Nbs1 (MRN) complex.
    Lee JH; Mand MR; Deshpande RA; Kinoshita E; Yang SH; Wyman C; Paull TT
    J Biol Chem; 2013 May; 288(18):12840-51. PubMed ID: 23525106
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template.
    Williams RS; Williams JS; Tainer JA
    Biochem Cell Biol; 2007 Aug; 85(4):509-20. PubMed ID: 17713585
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Localization of Double-Strand Break Repair Proteins to Viral Replication Compartments following Lytic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus.
    Hollingworth R; Horniblow RD; Forrest C; Stewart GS; Grand RJ
    J Virol; 2017 Nov; 91(22):. PubMed ID: 28855246
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Regulation of Mre11/Rad50 by Nbs1: effects on nucleotide-dependent DNA binding and association with ataxia-telangiectasia-like disorder mutant complexes.
    Lee JH; Ghirlando R; Bhaskara V; Hoffmeyer MR; Gu J; Paull TT
    J Biol Chem; 2003 Nov; 278(46):45171-81. PubMed ID: 12966088
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Rad17 recruits the MRE11-RAD50-NBS1 complex to regulate the cellular response to DNA double-strand breaks.
    Wang Q; Goldstein M; Alexander P; Wakeman TP; Sun T; Feng J; Lou Z; Kastan MB; Wang XF
    EMBO J; 2014 Apr; 33(8):862-77. PubMed ID: 24534091
    [TBL] [Abstract][Full Text] [Related]  

  • 7. MRE11-RAD50-NBS1 complex dictates DNA repair independent of H2AX.
    Yuan J; Chen J
    J Biol Chem; 2010 Jan; 285(2):1097-104. PubMed ID: 19910469
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Smad7 enhances ATM activity by facilitating the interaction between ATM and Mre11-Rad50-Nbs1 complex in DNA double-strand break repair.
    Park S; Kang JM; Kim SJ; Kim H; Hong S; Lee YJ; Kim SJ
    Cell Mol Life Sci; 2015 Feb; 72(3):583-596. PubMed ID: 25063542
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Rad50 ATPase activity is regulated by DNA ends and requires coordination of both active sites.
    Deshpande RA; Lee JH; Paull TT
    Nucleic Acids Res; 2017 May; 45(9):5255-5268. PubMed ID: 28369545
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Multiple roles for MRE11 at uncapped telomeres.
    Deng Y; Guo X; Ferguson DO; Chang S
    Nature; 2009 Aug; 460(7257):914-8. PubMed ID: 19633651
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Rad50 zinc hook is important for the Mre11 complex to bind chromosomal DNA double-stranded breaks and initiate various DNA damage responses.
    He J; Shi LZ; Truong LN; Lu CS; Razavian N; Li Y; Negrete A; Shiloach J; Berns MW; Wu X
    J Biol Chem; 2012 Sep; 287(38):31747-56. PubMed ID: 22833675
    [TBL] [Abstract][Full Text] [Related]  

  • 12. MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks.
    Helmink BA; Bredemeyer AL; Lee BS; Huang CY; Sharma GG; Walker LM; Bednarski JJ; Lee WL; Pandita TK; Bassing CH; Sleckman BP
    J Exp Med; 2009 Mar; 206(3):669-79. PubMed ID: 19221393
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Deubiquitinase USP2 stabilizes the MRE11-RAD50-NBS1 complex at DNA double-strand break sites by counteracting the ubiquitination of NBS1.
    Kim H; Kim D; Choi H; Shin G; Lee JK
    J Biol Chem; 2023 Jan; 299(1):102752. PubMed ID: 36436562
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Suppression of DNA-damage checkpoint signaling by Rsk-mediated phosphorylation of Mre11.
    Chen C; Zhang L; Huang NJ; Huang B; Kornbluth S
    Proc Natl Acad Sci U S A; 2013 Dec; 110(51):20605-10. PubMed ID: 24297933
    [TBL] [Abstract][Full Text] [Related]  

  • 15. DNA-dependent protein kinase regulates DNA end resection in concert with Mre11-Rad50-Nbs1 (MRN) and ataxia telangiectasia-mutated (ATM).
    Zhou Y; Paull TT
    J Biol Chem; 2013 Dec; 288(52):37112-25. PubMed ID: 24220101
    [TBL] [Abstract][Full Text] [Related]  

  • 16. ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex.
    Lee JH; Paull TT
    Science; 2005 Apr; 308(5721):551-4. PubMed ID: 15790808
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Stable maintenance of the Mre11-Rad50-Nbs1 complex is sufficient to restore the DNA double-strand break response in cells lacking RecQL4 helicase activity.
    Kim H; Choi H; Im JS; Park SY; Shin G; Yoo JH; Kim G; Lee JK
    J Biol Chem; 2021 Oct; 297(4):101148. PubMed ID: 34473993
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Nbs1 flexibly tethers Ctp1 and Mre11-Rad50 to coordinate DNA double-strand break processing and repair.
    Williams RS; Dodson GE; Limbo O; Yamada Y; Williams JS; Guenther G; Classen S; Glover JN; Iwasaki H; Russell P; Tainer JA
    Cell; 2009 Oct; 139(1):87-99. PubMed ID: 19804755
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Loss of the tumor suppressor BIN1 enables ATM Ser/Thr kinase activation by the nuclear protein E2F1 and renders cancer cells resistant to cisplatin.
    Folk WP; Kumari A; Iwasaki T; Pyndiah S; Johnson JC; Cassimere EK; Abdulovic-Cui AL; Sakamuro D
    J Biol Chem; 2019 Apr; 294(14):5700-5719. PubMed ID: 30733337
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Deletion of NAD(P)H:quinone oxidoreductase 1 represses Mre11-Rad50-Nbs1 complex protein expression in cisplatin-induced nephrotoxicity.
    Kim YJ; Kim TW; Park SR; Kim HT; Jung DY; Ryu SY; Jung JY
    Toxicol Lett; 2016 Jan; 243():22-30. PubMed ID: 26723870
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 17.