BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

195 related articles for article (PubMed ID: 25215937)

  • 1. Thymidine kinase 2 enzyme kinetics elucidate the mechanism of thymidine-induced mitochondrial DNA depletion.
    Sun R; Wang L
    Biochemistry; 2014 Oct; 53(39):6142-50. PubMed ID: 25215937
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Tissue specific distribution of pyrimidine deoxynucleoside salvage enzymes shed light on the mechanism of mitochondrial DNA depletion.
    Wang L; Eriksson S
    Nucleosides Nucleotides Nucleic Acids; 2010 Jun; 29(4-6):400-3. PubMed ID: 20544526
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Unchanged thymidine triphosphate pools and thymidine metabolism in two lines of thymidine kinase 2-mutated fibroblasts.
    Frangini M; Rampazzo C; Franzolin E; Lara MC; Vilà MR; Martí R; Bianchi V
    FEBS J; 2009 Feb; 276(4):1104-13. PubMed ID: 19154348
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Molecular and clinical characterization of the myopathic form of mitochondrial DNA depletion syndrome caused by mutations in the thymidine kinase (TK2) gene.
    Chanprasert S; Wang J; Weng SW; Enns GM; Boué DR; Wong BL; Mendell JR; Perry DA; Sahenk Z; Craigen WJ; Alcala FJ; Pascual JM; Melancon S; Zhang VW; Scaglia F; Wong LJ
    Mol Genet Metab; 2013; 110(1-2):153-61. PubMed ID: 23932787
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Recent advances in thymidine kinase 2 (TK2) inhibitors and new perspectives for potential applications.
    Priego EM; Karlsson A; Gago F; Camarasa MJ; Balzarini J; Pérez-Pérez MJ
    Curr Pharm Des; 2012; 18(20):2981-94. PubMed ID: 22571666
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Cloning and characterization of full-length mouse thymidine kinase 2: the N-terminal sequence directs import of the precursor protein into mitochondria.
    Wang L; Eriksson S
    Biochem J; 2000 Oct; 351 Pt 2(Pt 2):469-76. PubMed ID: 11023833
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Two novel mutations in thymidine kinase-2 cause early onset fatal encephalomyopathy and severe mtDNA depletion.
    Lesko N; Naess K; Wibom R; Solaroli N; Nennesmo I; von Döbeln U; Karlsson A; Larsson NG
    Neuromuscul Disord; 2010 Mar; 20(3):198-203. PubMed ID: 20083405
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The kinetic effects on thymidine kinase 2 by enzyme-bound dTTP may explain the mitochondrial side effects of antiviral thymidine analogs.
    Wang L; Sun R; Eriksson S
    Antimicrob Agents Chemother; 2011 Jun; 55(6):2552-8. PubMed ID: 21444706
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Negative Cooperative Binding of Thymidine, Ordered Substrate Binding, and Product Release of Human Mitochondrial Thymidine Kinase 2 Explain Its Complex Kinetic Properties and Physiological Functions.
    Wang L; Zhang L; Sun R; Eriksson S
    ACS Omega; 2018 Aug; 3(8):8971-8979. PubMed ID: 31459030
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Depletion of the other genome-mitochondrial DNA depletion syndromes in humans.
    Elpeleg O; Mandel H; Saada A
    J Mol Med (Berl); 2002 Jul; 80(7):389-96. PubMed ID: 12110944
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Identification and characterization of mitochondrial factors modulating thymidine kinase 2 activity.
    Sun R; Eriksson S; Wang L
    Nucleosides Nucleotides Nucleic Acids; 2010 Jun; 29(4-6):382-5. PubMed ID: 20544523
    [TBL] [Abstract][Full Text] [Related]  

  • 12. 5-Bromovinyl 2'-deoxyuridine phosphorylation by mitochondrial and cytosolic thymidine kinase (TK2 and TK1) and its use in selective measurement of TK2 activity in crude extracts.
    Wang L; Eriksson S
    Nucleosides Nucleotides Nucleic Acids; 2008 Jun; 27(6):858-62. PubMed ID: 18600552
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Clinical spectrum of mitochondrial DNA depletion due to mutations in the thymidine kinase 2 gene.
    Oskoui M; Davidzon G; Pascual J; Erazo R; Gurgel-Giannetti J; Krishna S; Bonilla E; De Vivo DC; Shanske S; DiMauro S
    Arch Neurol; 2006 Aug; 63(8):1122-6. PubMed ID: 16908738
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Deoxyribonucleoside kinases in mitochondrial DNA depletion.
    Saada-Reisch A
    Nucleosides Nucleotides Nucleic Acids; 2004 Oct; 23(8-9):1205-15. PubMed ID: 15571232
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Targeted impairment of thymidine kinase 2 expression in cells induces mitochondrial DNA depletion and reveals molecular mechanisms of compensation of mitochondrial respiratory activity.
    Villarroya J; Lara MC; Dorado B; Garrido M; García-Arumí E; Meseguer A; Hirano M; Vilà MR
    Biochem Biophys Res Commun; 2011 Apr; 407(2):333-8. PubMed ID: 21382338
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Deoxycytidine and Deoxythymidine Treatment for Thymidine Kinase 2 Deficiency.
    Lopez-Gomez C; Levy RJ; Sanchez-Quintero MJ; Juanola-Falgarona M; Barca E; Garcia-Diaz B; Tadesse S; Garone C; Hirano M
    Ann Neurol; 2017 May; 81(5):641-652. PubMed ID: 28318037
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Thymidine kinase 2 mutations in autosomal recessive progressive external ophthalmoplegia with multiple mitochondrial DNA deletions.
    Tyynismaa H; Sun R; Ahola-Erkkilä S; Almusa H; Pöyhönen R; Korpela M; Honkaniemi J; Isohanni P; Paetau A; Wang L; Suomalainen A
    Hum Mol Genet; 2012 Jan; 21(1):66-75. PubMed ID: 21937588
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Mutant mitochondrial thymidine kinase in mitochondrial DNA depletion myopathy.
    Saada A; Shaag A; Mandel H; Nevo Y; Eriksson S; Elpeleg O
    Nat Genet; 2001 Nov; 29(3):342-4. PubMed ID: 11687801
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Retained sensitivity to cytotoxic pyrimidine nucleoside analogs in thymidine kinase 2 deficient human fibroblasts.
    Bjerke M; Solaroli N; Lesko N; Balzarini J; Johansson M; Karlsson A
    Nucleosides Nucleotides Nucleic Acids; 2010 Jan; 29(1):1-13. PubMed ID: 20391188
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Structure, physiological role, and specific inhibitors of human thymidine kinase 2 (TK2): present and future.
    Pérez-Pérez MJ; Priego EM; Hernández AI; Familiar O; Camarasa MJ; Negri A; Gago F; Balzarini J
    Med Res Rev; 2008 Sep; 28(5):797-820. PubMed ID: 18459168
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.