These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

143 related articles for article (PubMed ID: 25225654)

  • 1. Virtual screening and optimization of Type II inhibitors of JAK2 from a natural product library.
    Ma DL; Chan DS; Wei G; Zhong HJ; Yang H; Leung LT; Gullen EA; Chiu P; Cheng YC; Leung CH
    Chem Commun (Camb); 2014 Nov; 50(90):13885-8. PubMed ID: 25225654
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structure-based discovery and development of natural products as Type II JAK2 inhibitors for the treatment of hepatitis C.
    Ma ED; Leung CH; Chiu P; Cheng YC
    Hong Kong Med J; 2016 Jun; 22(3 Suppl 4):32-6. PubMed ID: 27390008
    [No Abstract]   [Full Text] [Related]  

  • 3. In silico identification of natural product inhibitors of JAK2.
    Zhong HJ; Lin S; Tam IL; Lu L; Chan DS; Ma DL; Leung CH
    Methods; 2015 Jan; 71():21-5. PubMed ID: 25038528
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Identification of a novel inhibitor of JAK2 tyrosine kinase by structure-based virtual screening.
    Kiss R; Polgár T; Kirabo A; Sayyah J; Figueroa NC; List AF; Sokol L; Zuckerman KS; Gali M; Bisht KS; Sayeski PP; Keseru GM
    Bioorg Med Chem Lett; 2009 Jul; 19(13):3598-601. PubMed ID: 19447617
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Screening of a virtual mirror-image library of natural products.
    Noguchi T; Oishi S; Honda K; Kondoh Y; Saito T; Ohno H; Osada H; Fujii N
    Chem Commun (Camb); 2016 Jun; 52(49):7653-6. PubMed ID: 27198617
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The impact of binding site waters on the activity/selectivity trade-off of Janus kinase 2 (JAK2) inhibitors.
    Egyed A; Bajusz D; Keserű GM
    Bioorg Med Chem; 2019 Apr; 27(8):1497-1508. PubMed ID: 30833158
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Searching for Novel Janus Kinase-2 Inhibitors Using a Combination of Pharmacophore Modeling, 3D-QSAR Studies and Virtual Screening.
    Vrontaki E; Melagraki G; Afantitis A; Mavromoustakos T; Kollias G
    Mini Rev Med Chem; 2017; 17(3):268-294. PubMed ID: 27659251
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Computer-aided discovery of aminopyridines as novel JAK2 inhibitors.
    Zhao C; Yang SH; Khadka DB; Jin Y; Lee KT; Cho WJ
    Bioorg Med Chem; 2015 Mar; 23(5):985-95. PubMed ID: 25650310
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Structure-based library design in efficient discovery of novel inhibitors.
    Yan S; Selliah R
    Methods Mol Biol; 2011; 685():175-90. PubMed ID: 20981524
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Discovery and optimization of 2-aminopyridine derivatives as novel and selective JAK2 inhibitors.
    Ma X; Diao Y; Ge H; Xu F; Zhu L; Zhao Z; Li H
    Bioorg Med Chem Lett; 2020 Apr; 30(8):127048. PubMed ID: 32122740
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Identification and characterization of agnuside, a natural proangiogenic small molecule.
    Pillarisetti P; Myers KA
    Eur J Med Chem; 2018 Dec; 160():193-206. PubMed ID: 30340142
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The discovery of reverse tricyclic pyridone JAK2 inhibitors. Part 2: lead optimization.
    Siu T; Kumarasinghe SE; Altman MD; Katcher M; Northrup A; White C; Rosenstein C; Mathur A; Xu L; Chan G; Bachman E; Bouthillette M; Dinsmore CJ; Marshall CG; Young JR
    Bioorg Med Chem Lett; 2014 Mar; 24(6):1466-71. PubMed ID: 24582987
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Discovery of highly potent small molecule Hepatitis C Virus entry inhibitors.
    Mittapalli GK; Jackson A; Zhao F; Lee H; Chow S; McKelvy J; Wong-Staal F; Macdonald JE
    Bioorg Med Chem Lett; 2011 Nov; 21(22):6852-5. PubMed ID: 21978675
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Focused library with a core structure extracted from natural products and modified: application to phosphatase inhibitors and several biochemical findings.
    Hirai G; Sodeoka M
    Acc Chem Res; 2015 May; 48(5):1464-73. PubMed ID: 25894598
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Insights into the Structural Features Essential for JAK2 Inhibition and Selectivity.
    Zhao C; Khadka DB; Cho WJ
    Curr Med Chem; 2016; 23(13):1331-55. PubMed ID: 27048338
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Dual inhibitors of Janus kinase 2 and 3 (JAK2/3): designing by pharmacophore- and docking-based virtual screening approach.
    Jasuja H; Chadha N; Kaur M; Silakari O
    Mol Divers; 2014 May; 18(2):253-67. PubMed ID: 24415188
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Identification of novel SAR properties of the Jak2 small molecule inhibitor G6: significance of the para-hydroxyl orientation.
    Baskin R; Gali M; Park SO; Zhao ZJ; Keseru GM; Bisht KS; Sayeski PP
    Bioorg Med Chem Lett; 2012 Feb; 22(3):1402-7. PubMed ID: 22227213
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Discovery of potent and selective pyrazolopyrimidine janus kinase 2 inhibitors.
    Hanan EJ; van Abbema A; Barrett K; Blair WS; Blaney J; Chang C; Eigenbrot C; Flynn S; Gibbons P; Hurley CA; Kenny JR; Kulagowski J; Lee L; Magnuson SR; Morris C; Murray J; Pastor RM; Rawson T; Siu M; Ultsch M; Zhou A; Sampath D; Lyssikatos JP
    J Med Chem; 2012 Nov; 55(22):10090-107. PubMed ID: 23061660
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Design of novel rho kinase inhibitors using energy based pharmacophore modeling, shape-based screening, in silico virtual screening, and biological evaluation.
    Mishra RK; Alokam R; Singhal SM; Srivathsav G; Sriram D; Kaushik-Basu N; Manvar D; Yogeeswari P
    J Chem Inf Model; 2014 Oct; 54(10):2876-86. PubMed ID: 25254429
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Discovery of Subtype Selective Janus Kinase (JAK) Inhibitors by Structure-Based Virtual Screening.
    Bajusz D; Ferenczy GG; Keserű GM
    J Chem Inf Model; 2016 Jan; 56(1):234-47. PubMed ID: 26682735
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.