243 related articles for article (PubMed ID: 25226616)
1. Assessment of the effect of sphingosine kinase inhibitors on apoptosis,unfolded protein response and autophagy of T-cell acute lymphoblastic leukemia cells; indications for novel therapeutics.
Evangelisti C; Evangelisti C; Teti G; Chiarini F; Falconi M; Melchionda F; Pession A; Bertaina A; Locatelli F; McCubrey JA; Beak DJ; Bittman R; Pyne S; Pyne NJ; Martelli AM
Oncotarget; 2014 Sep; 5(17):7886-901. PubMed ID: 25226616
[TBL] [Abstract][Full Text] [Related]
2. The sphingosine kinase inhibitor 2-(p-hyroxyanilino)-4-(p-chlorophenyl)thiazole reduces androgen receptor expression via an oxidative stress-dependent mechanism.
Tonelli F; Alossaimi M; Williamson L; Tate RJ; Watson DG; Chan E; Bittman R; Pyne NJ; Pyne S
Br J Pharmacol; 2013 Mar; 168(6):1497-505. PubMed ID: 23113536
[TBL] [Abstract][Full Text] [Related]
3. (R)-FTY720 methyl ether is a specific sphingosine kinase 2 inhibitor: Effect on sphingosine kinase 2 expression in HEK 293 cells and actin rearrangement and survival of MCF-7 breast cancer cells.
Lim KG; Sun C; Bittman R; Pyne NJ; Pyne S
Cell Signal; 2011 Oct; 23(10):1590-5. PubMed ID: 21620961
[TBL] [Abstract][Full Text] [Related]
4. FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells.
Tonelli F; Lim KG; Loveridge C; Long J; Pitson SM; Tigyi G; Bittman R; Pyne S; Pyne NJ
Cell Signal; 2010 Oct; 22(10):1536-42. PubMed ID: 20570726
[TBL] [Abstract][Full Text] [Related]
5. FTY720 analogues as sphingosine kinase 1 inhibitors: enzyme inhibition kinetics, allosterism, proteasomal degradation, and actin rearrangement in MCF-7 breast cancer cells.
Lim KG; Tonelli F; Li Z; Lu X; Bittman R; Pyne S; Pyne NJ
J Biol Chem; 2011 May; 286(21):18633-40. PubMed ID: 21464128
[TBL] [Abstract][Full Text] [Related]
6. Dimethylsphingosine and FTY720 inhibit the SK1 form but activate the SK2 form of sphingosine kinase from rat heart.
Vessey DA; Kelley M; Zhang J; Li L; Tao R; Karliner JS
J Biochem Mol Toxicol; 2007; 21(5):273-9. PubMed ID: 17912702
[TBL] [Abstract][Full Text] [Related]
7. Structure-function analysis of lipid substrates and inhibitors of sphingosine kinases.
Adams DR; Pyne S; Pyne NJ
Cell Signal; 2020 Dec; 76():109806. PubMed ID: 33035646
[TBL] [Abstract][Full Text] [Related]
8. The roles of sphingosine kinases 1 and 2 in regulating the Warburg effect in prostate cancer cells.
Watson DG; Tonelli F; Alossaimi M; Williamson L; Chan E; Gorshkova I; Berdyshev E; Bittman R; Pyne NJ; Pyne S
Cell Signal; 2013 Apr; 25(4):1011-7. PubMed ID: 23314175
[TBL] [Abstract][Full Text] [Related]
9. A novel sphingosine kinase inhibitor induces autophagy in tumor cells.
Beljanski V; Knaak C; Smith CD
J Pharmacol Exp Ther; 2010 May; 333(2):454-64. PubMed ID: 20179157
[TBL] [Abstract][Full Text] [Related]
10. Synergistic cytotoxic effects of bortezomib and CK2 inhibitor CX-4945 in acute lymphoblastic leukemia: turning off the prosurvival ER chaperone BIP/Grp78 and turning on the pro-apoptotic NF-κB.
Buontempo F; Orsini E; Lonetti A; Cappellini A; Chiarini F; Evangelisti C; Evangelisti C; Melchionda F; Pession A; Bertaina A; Locatelli F; Bertacchini J; Neri LM; McCubrey JA; Martelli AM
Oncotarget; 2016 Jan; 7(2):1323-40. PubMed ID: 26593250
[TBL] [Abstract][Full Text] [Related]
11. Effects of phosphorylation of immunomodulatory agent FTY720 (fingolimod) on antiproliferative activity against breast and colon cancer cells.
Nagaoka Y; Otsuki K; Fujita T; Uesato S
Biol Pharm Bull; 2008 Jun; 31(6):1177-81. PubMed ID: 18520051
[TBL] [Abstract][Full Text] [Related]
12. Sphingosine kinase inhibitors decrease viability and induce cell death in natural killer-large granular lymphocyte leukemia.
LeBlanc FR; Liu X; Hengst J; Fox T; Calvert V; Petricoin EF; Yun J; Feith DJ; Loughran TP
Cancer Biol Ther; 2015; 16(12):1830-40. PubMed ID: 26252351
[TBL] [Abstract][Full Text] [Related]
13. Proteasomal degradation of sphingosine kinase 1 and inhibition of dihydroceramide desaturase by the sphingosine kinase inhibitors, SKi or ABC294640, induces growth arrest in androgen-independent LNCaP-AI prostate cancer cells.
McNaughton M; Pitman M; Pitson SM; Pyne NJ; Pyne S
Oncotarget; 2016 Mar; 7(13):16663-75. PubMed ID: 26934645
[TBL] [Abstract][Full Text] [Related]
14. "Inside-out" signaling of sphingosine-1-phosphate: therapeutic targets.
Takabe K; Paugh SW; Milstien S; Spiegel S
Pharmacol Rev; 2008 Jun; 60(2):181-95. PubMed ID: 18552276
[TBL] [Abstract][Full Text] [Related]
15. A sphingosine kinase inhibitor combined with temozolomide induces glioblastoma cell death through accumulation of dihydrosphingosine and dihydroceramide, endoplasmic reticulum stress and autophagy.
Noack J; Choi J; Richter K; Kopp-Schneider A; Régnier-Vigouroux A
Cell Death Dis; 2014 Sep; 5(9):e1425. PubMed ID: 25255218
[TBL] [Abstract][Full Text] [Related]
16. A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia.
Paugh SW; Paugh BS; Rahmani M; Kapitonov D; Almenara JA; Kordula T; Milstien S; Adams JK; Zipkin RE; Grant S; Spiegel S
Blood; 2008 Aug; 112(4):1382-91. PubMed ID: 18511810
[TBL] [Abstract][Full Text] [Related]
17. Sphingosine kinase 2 prevents the nuclear translocation of sphingosine 1-phosphate receptor-2 and tyrosine 416 phosphorylated c-Src and increases estrogen receptor negative MDA-MB-231 breast cancer cell growth: The role of sphingosine 1-phosphate receptor-4.
Ohotski J; Rosen H; Bittman R; Pyne S; Pyne NJ
Cell Signal; 2014 May; 26(5):1040-7. PubMed ID: 24486401
[TBL] [Abstract][Full Text] [Related]
18. Altering the sphingosine-1-phosphate/ceramide balance: a promising approach for tumor therapy.
Huwiler A; Pfeilschifter J
Curr Pharm Des; 2006; 12(35):4625-35. PubMed ID: 17168766
[TBL] [Abstract][Full Text] [Related]
19. Short Periods of Hypoxia Upregulate Sphingosine Kinase 1 and Increase Vasodilation of Arteries to Sphingosine 1-Phosphate (S1P) via S1P
Alganga H; Almabrouk TAM; Katwan OJ; Daly CJ; Pyne S; Pyne NJ; Kennedy S
J Pharmacol Exp Ther; 2019 Oct; 371(1):63-74. PubMed ID: 31371480
[TBL] [Abstract][Full Text] [Related]
20. Sphingosine kinase 1 as a potential therapeutic target in epithelial ovarian cancer.
Lee JW; Ryu JY; Yoon G; Jeon HK; Cho YJ; Choi JJ; Song SY; Do IG; Lee YY; Kim TJ; Choi CH; Kim BG; Bae DS
Int J Cancer; 2015 Jul; 137(1):221-9. PubMed ID: 25429856
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]