BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

266 related articles for article (PubMed ID: 25239453)

  • 1. BRCA1 suppresses epithelial-to-mesenchymal transition and stem cell dedifferentiation during mammary and tumor development.
    Bai F; Chan HL; Scott A; Smith MD; Fan C; Herschkowitz JI; Perou CM; Livingstone AS; Robbins DJ; Capobianco AJ; Pei XH
    Cancer Res; 2014 Nov; 74(21):6161-72. PubMed ID: 25239453
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Estrogen promotes estrogen receptor negative BRCA1-deficient tumor initiation and progression.
    Wang C; Bai F; Zhang LH; Scott A; Li E; Pei XH
    Breast Cancer Res; 2018 Jul; 20(1):74. PubMed ID: 29996906
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Germline mutation of Brca1 alters the fate of mammary luminal cells and causes luminal-to-basal mammary tumor transformation.
    Bai F; Smith MD; Chan HL; Pei XH
    Oncogene; 2013 May; 32(22):2715-25. PubMed ID: 22777348
    [TBL] [Abstract][Full Text] [Related]  

  • 4. PDGFRβ is an essential therapeutic target for BRCA1-deficient mammary tumors.
    Bai F; Liu S; Liu X; Hollern DP; Scott A; Wang C; Zhang L; Fan C; Fu L; Perou CM; Zhu WG; Pei XH
    Breast Cancer Res; 2021 Jan; 23(1):10. PubMed ID: 33478572
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Loss of function of BRCA1 promotes EMT in mammary tumors through activation of TGFβR2 signaling pathway.
    Bai F; Wang C; Liu X; Hollern D; Liu S; Fan C; Liu C; Ren S; Herschkowitz JI; Zhu WG; Pei XH
    Cell Death Dis; 2022 Mar; 13(3):195. PubMed ID: 35236825
    [TBL] [Abstract][Full Text] [Related]  

  • 6. GATA3 functions downstream of BRCA1 to suppress EMT in breast cancer.
    Bai F; Zhang LH; Liu X; Wang C; Zheng C; Sun J; Li M; Zhu WG; Pei XH
    Theranostics; 2021; 11(17):8218-8233. PubMed ID: 34373738
    [No Abstract]   [Full Text] [Related]  

  • 7. Dissecting the heterogeneity and tumorigenesis of BRCA1 deficient mammary tumors via single cell RNA sequencing.
    Sun H; Zeng J; Miao Z; Lei KC; Huang C; Hu L; Su SM; Chan UI; Miao K; Zhang X; Zhang A; Guo S; Chen S; Meng Y; Deng M; Hao W; Lei H; Lin Y; Yang Z; Tang D; Wong KH; Zhang XD; Xu X; Deng CX
    Theranostics; 2021; 11(20):9967-9987. PubMed ID: 34815798
    [No Abstract]   [Full Text] [Related]  

  • 8. p16INK4a suppresses BRCA1-deficient mammary tumorigenesis.
    Scott A; Bai F; Chan HL; Liu S; Ma J; Slingerland JM; Robbins DJ; Capobianco AJ; Pei XH
    Oncotarget; 2016 Dec; 7(51):84496-84507. PubMed ID: 27811360
    [TBL] [Abstract][Full Text] [Related]  

  • 9. GATA3 functions downstream of BRCA1 to promote DNA damage repair and suppress dedifferentiation in breast cancer.
    Wang X; Bai F; Liu X; Peng B; Xu X; Zhang H; Fu L; Zhu WG; Wang B; Pei XH
    BMC Biol; 2024 Apr; 22(1):85. PubMed ID: 38627785
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Loss of function of GATA3 regulates FRA1 and c-FOS to activate EMT and promote mammary tumorigenesis and metastasis.
    Liu X; Bai F; Wang Y; Wang C; Chan HL; Zheng C; Fang J; Zhu WG; Pei XH
    Cell Death Dis; 2023 Jun; 14(6):370. PubMed ID: 37353480
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Selective mode of action of plumbagin through BRCA1 deficient breast cancer stem cells.
    Somasundaram V; Hemalatha SK; Pal K; Sinha S; Nair AS; Mukhopadhyay D; Srinivas P
    BMC Cancer; 2016 May; 16():336. PubMed ID: 27229859
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The dual role of FOXF2 in regulation of DNA replication and the epithelial-mesenchymal transition in breast cancer progression.
    Lo PK; Lee JS; Liang X; Sukumar S
    Cell Signal; 2016 Oct; 28(10):1502-19. PubMed ID: 27377963
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Loss of Brca1 and Trp53 in adult mouse mammary ductal epithelium results in development of hormone receptor-positive or hormone receptor-negative tumors, depending on inactivation of Rb family proteins.
    Szabova L; Gordon MB; Lu L; Pate N; Bassel L; Iacovelli AJ; Karim B; Homan PJ; Householder DB; Guerin TM; Burkett S; Day AM; Custer W; Weaver Ohler Z
    Breast Cancer Res; 2022 Nov; 24(1):75. PubMed ID: 36333737
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Progesterone receptor A stability is mediated by glycogen synthase kinase-3β in the Brca1-deficient mammary gland.
    Wang S; Li Y; Hsu PH; Lee SY; Kim Y; Lee EYP
    J Biol Chem; 2013 Sep; 288(36):26265-26274. PubMed ID: 23880761
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Loss of function of GATA3 induces basal-like mammary tumors.
    Bai F; Zheng C; Liu X; Chan HL; Liu S; Ma J; Ren S; Zhu WG; Pei XH
    Theranostics; 2022; 12(2):720-733. PubMed ID: 34976209
    [No Abstract]   [Full Text] [Related]  

  • 16. BRCA1 regulates human mammary stem/progenitor cell fate.
    Liu S; Ginestier C; Charafe-Jauffret E; Foco H; Kleer CG; Merajver SD; Dontu G; Wicha MS
    Proc Natl Acad Sci U S A; 2008 Feb; 105(5):1680-5. PubMed ID: 18230721
    [TBL] [Abstract][Full Text] [Related]  

  • 17. CDK inhibitor p18(INK4c) is a downstream target of GATA3 and restrains mammary luminal progenitor cell proliferation and tumorigenesis.
    Pei XH; Bai F; Smith MD; Usary J; Fan C; Pai SY; Ho IC; Perou CM; Xiong Y
    Cancer Cell; 2009 May; 15(5):389-401. PubMed ID: 19411068
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer.
    Liu X; Holstege H; van der Gulden H; Treur-Mulder M; Zevenhoven J; Velds A; Kerkhoven RM; van Vliet MH; Wessels LF; Peterse JL; Berns A; Jonkers J
    Proc Natl Acad Sci U S A; 2007 Jul; 104(29):12111-6. PubMed ID: 17626182
    [TBL] [Abstract][Full Text] [Related]  

  • 19. EMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors in transgenic mice.
    Morel AP; Hinkal GW; Thomas C; Fauvet F; Courtois-Cox S; Wierinckx A; Devouassoux-Shisheboran M; Treilleux I; Tissier A; Gras B; Pourchet J; Puisieux I; Browne GJ; Spicer DB; Lachuer J; Ansieau S; Puisieux A
    PLoS Genet; 2012; 8(5):e1002723. PubMed ID: 22654675
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Embryonic mammary signature subsets are activated in Brca1-/- and basal-like breast cancers.
    Zvelebil M; Oliemuller E; Gao Q; Wansbury O; Mackay A; Kendrick H; Smalley MJ; Reis-Filho JS; Howard BA
    Breast Cancer Res; 2013 Mar; 15(2):R25. PubMed ID: 23506684
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.