222 related articles for article (PubMed ID: 25240093)
1. Ring fusion strategy for the synthesis of anthra[2,3-d]oxazole-2-thione-5,10-dione homologues as DNA topoisomerase inhibitors and as antitumor agents.
Chen CL; Liu FL; Lee CC; Chen TC; Chang WW; Guh JH; Ahmed Ali AA; Chang DM; Huang HS
Eur J Med Chem; 2014 Nov; 87():30-8. PubMed ID: 25240093
[TBL] [Abstract][Full Text] [Related]
2. Ring fusion strategy for synthesis and lead optimization of sulfur-substituted anthra[1,2-c][1,2,5]thiadiazole-6,11-dione derivatives as promising scaffold of antitumor agents.
Lee YR; Chen TC; Lee CC; Chen CL; Ahmed Ali AA; Tikhomirov A; Guh JH; Yu DS; Huang HS
Eur J Med Chem; 2015 Sep; 102():661-76. PubMed ID: 26344783
[TBL] [Abstract][Full Text] [Related]
3. Structure-based design, synthesis and biological evaluation of novel anthra[1,2-d]imidazole-6,11-dione homologues as potential antitumor agents.
Chen TC; Yu DS; Huang KF; Fu YC; Lee CC; Chen CL; Huang FC; Hsieh HH; Lin JJ; Huang HS
Eur J Med Chem; 2013 Nov; 69():278-93. PubMed ID: 24051300
[TBL] [Abstract][Full Text] [Related]
4. Design, synthesis, topoisomerase I & II inhibitory activity, antiproliferative activity, and structure-activity relationship study of pyrazoline derivatives: An ATP-competitive human topoisomerase IIα catalytic inhibitor.
Ahmad P; Woo H; Jun KY; Kadi AA; Abdel-Aziz HA; Kwon Y; Rahman AF
Bioorg Med Chem; 2016 Apr; 24(8):1898-908. PubMed ID: 26988802
[TBL] [Abstract][Full Text] [Related]
5. Design, synthesis and antiproliferative evaluation of fluorenone analogs with DNA topoisomerase I inhibitory properties.
Lee CC; Chang DM; Huang KF; Chen CL; Chen TC; Lo Y; Guh JH; Huang HS
Bioorg Med Chem; 2013 Nov; 21(22):7125-33. PubMed ID: 24094433
[TBL] [Abstract][Full Text] [Related]
6. Synthesis and evaluation of new antitumor 3-aminomethyl-4,11-dihydroxynaphtho[2,3-f]indole-5,10-diones.
Shchekotikhin AE; Glazunova VA; Dezhenkova LG; Luzikov YN; Buyanov VN; Treshalina HM; Lesnaya NA; Romanenko VI; Kaluzhny DN; Balzarini J; Agama K; Pommier Y; Shtil AA; Preobrazhenskaya MN
Eur J Med Chem; 2014 Oct; 86():797-805. PubMed ID: 25244612
[TBL] [Abstract][Full Text] [Related]
7. Topoisomerase I-mediated DNA cleavage as a guide to the development of antitumor agents derived from the marine alkaloid lamellarin D: triester derivatives incorporating amino acid residues.
Tardy C; Facompré M; Laine W; Baldeyrou B; García-Gravalos D; Francesch A; Mateo C; Pastor A; Jiménez JA; Manzanares I; Cuevas C; Bailly C
Bioorg Med Chem; 2004 Apr; 12(7):1697-712. PubMed ID: 15028262
[TBL] [Abstract][Full Text] [Related]
8. Natural product-based design, synthesis and biological evaluation of anthra[2,1-d]thiazole-6,11-dione derivatives from rhein as novel antitumour agents.
Liang YK; Yue ZZ; Li JX; Tan C; Miao ZH; Tan WF; Yang CH
Eur J Med Chem; 2014 Sep; 84():505-15. PubMed ID: 25050882
[TBL] [Abstract][Full Text] [Related]
9. Development of 13H-benzo[f]chromeno[4,3-b][1,7]naphthyridines and their salts as potent cytotoxic agents and topoisomerase I/IIα inhibitors.
Arepalli SK; Lee C; Sim S; Lee K; Jo H; Jun KY; Kwon Y; Kang JS; Jung JK; Lee H
Bioorg Med Chem; 2018 Oct; 26(18):5181-5193. PubMed ID: 30253887
[TBL] [Abstract][Full Text] [Related]
10. Design and synthesis of 2-phenylnaphthalenoids and 2-phenylbenzofuranoids as DNA topoisomerase inhibitors and antitumor agents.
Hao H; Chen W; Zhu J; Lu C; Shen Y
Eur J Med Chem; 2015 Sep; 102():277-87. PubMed ID: 26291037
[TBL] [Abstract][Full Text] [Related]
11. Cytotoxicity and DNA topoisomerase inhibitory activity of benz[f]indole-4,9-dione analogs.
Park HJ; Lee HJ; Lee EJ; Hwang HJ; Shin SH; Suh ME; Kim C; Kim HJ; Seo EK; Lee SK
Biosci Biotechnol Biochem; 2003 Sep; 67(9):1944-9. PubMed ID: 14519980
[TBL] [Abstract][Full Text] [Related]
12. Structure-based design, synthesis and evaluation of novel anthra[1,2-d]imidazole-6,11-dione derivatives as telomerase inhibitors and potential for cancer polypharmacology.
Chen CL; Chang DM; Chen TC; Lee CC; Hsieh HH; Huang FC; Huang KF; Guh JH; Lin JJ; Huang HS
Eur J Med Chem; 2013 Feb; 60():29-41. PubMed ID: 23279865
[TBL] [Abstract][Full Text] [Related]
13. Synthesis and topoisomerases inhibitory activity of heteroaromatic chalcones.
Jeon KH; Yu HB; Kwak SY; Kwon Y; Na Y
Bioorg Med Chem; 2016 Nov; 24(22):5921-5928. PubMed ID: 27707625
[TBL] [Abstract][Full Text] [Related]
14. Design, synthesis and evaluation of 4-substituted anthra[2,1-c][1,2,5]thiadiazole-6,11-dione derivatives as novel non-camptothecin topoisomerase I inhibitors.
Dong G; Fang Y; Liu Y; Liu N; Wu S; Zhang W; Sheng C
Bioorg Med Chem Lett; 2017 May; 27(9):1929-1933. PubMed ID: 28351590
[TBL] [Abstract][Full Text] [Related]
15. Synthesis, cytotoxicity and human telomerase inhibition activities of a series of 1,2-heteroannelated anthraquinones and anthra[1,2-d]imidazole-6,11-dione homologues.
Huang HS; Chen TC; Chen RH; Huang KF; Huang FC; Jhan JR; Chen CL; Lee CC; Lo Y; Lin JJ
Bioorg Med Chem; 2009 Nov; 17(21):7418-28. PubMed ID: 19804981
[TBL] [Abstract][Full Text] [Related]
16. Structure-based hybridization, synthesis and biological evaluation of novel tetracyclic heterocyclic azathioxanthone analogues as potential antitumor agents.
Chen TC; Wu CL; Lee CC; Chen CL; Yu DS; Huang HS
Eur J Med Chem; 2015 Oct; 103():615-27. PubMed ID: 25799376
[TBL] [Abstract][Full Text] [Related]
17. A rational design strategy of the novel topoisomerase II inhibitors for the synthesis of the 4-O-(2-pyrazinecarboxylic)-4'-demethylepipodophyllotoxin with antitumor activity by diminishing the relaxation reaction of topoisomerase II-DNA decatenation.
Zhao W; Chen L; Li HM; Wang DJ; Li DS; Chen T; Yuan ZP; Tang YJ
Bioorg Med Chem; 2014 Jun; 22(11):2998-3007. PubMed ID: 24775914
[TBL] [Abstract][Full Text] [Related]
18. Synthesis, anticancer evaluation and molecular docking studies of new heterocycles linked to sulfonamide moiety as novel human topoisomerase types I and II poisons.
Halawa AH; Elgammal WE; Hassan SM; Hassan AH; Nassar HS; Ebrahim HY; Mehany ABM; El-Agrody AM
Bioorg Chem; 2020 May; 98():103725. PubMed ID: 32199303
[TBL] [Abstract][Full Text] [Related]
19. Synthesis of Novel Pyrazole Derivatives as Promising DNA-Binding Agents and Evaluation of Antitumor and Antitopoisomerases I/II Activities.
Feng J; Qi H; Sun X; Feng S; Liu Z; Song Y; Qiao X
Chem Pharm Bull (Tokyo); 2018 Nov; 66(11):1065-1071. PubMed ID: 30197406
[TBL] [Abstract][Full Text] [Related]
20. 11-Substituted Benzo[c]phenanthridines: New Structures and Insight into Their Mode of Antiproliferative Action.
Clement B; Girreser U; Steinhauer TN; Meier C; Marko D; Aichinger G; Kaltefleiter I; Stenzel L; Heber D; Weide M; Wolschendorf U; Zebothsen I; Zur Nieden D
ChemMedChem; 2016 Oct; 11(19):2155-2170. PubMed ID: 27546098
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
