BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

136 related articles for article (PubMed ID: 25251696)

  • 1. New CYP17 hydroxylase inhibitors: synthesis, biological evaluation, QSAR, and molecular docking study of new pregnenolone analogs.
    Al-Masoudi NA; Ali DS; Saeed B; Hartmann RW; Engel M; Rashid S; Saeed A
    Arch Pharm (Weinheim); 2014 Dec; 347(12):896-907. PubMed ID: 25251696
    [TBL] [Abstract][Full Text] [Related]  

  • 2. New biaryl-chalcone derivatives of pregnenolone via Suzuki-Miyaura cross-coupling reaction. Synthesis, CYP17 hydroxylase inhibition activity, QSAR, and molecular docking study.
    Al-Masoudi NA; Kadhim RA; Abdul-Rida NA; Saeed BA; Engel M
    Steroids; 2015 Sep; 101():43-50. PubMed ID: 26051784
    [TBL] [Abstract][Full Text] [Related]  

  • 3. A new pregnenolone analogues as privileged scaffolds in inhibition of CYP17 hydroxylase enzyme. Synthesis and in silico molecular docking study.
    Al-Masoudi NA; Mahdi KM; Abdul-Rida NA; Saeed BA; Engel M
    Steroids; 2015 Aug; 100():52-9. PubMed ID: 25988615
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Novel CYP17 inhibitors: synthesis, biological evaluation, structure-activity relationships and modelling of methoxy- and hydroxy-substituted methyleneimidazolyl biphenyls.
    Hille UE; Hu Q; Vock C; Negri M; Bartels M; Müller-Vieira U; Lauterbach T; Hartmann RW
    Eur J Med Chem; 2009 Jul; 44(7):2765-75. PubMed ID: 19211174
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Novel oxazolinyl derivatives of pregna-5,17(20)-diene as 17α-hydroxylase/17,20-lyase (CYP17A1) inhibitors.
    Kuzikov AV; Dugin NO; Stulov SV; Shcherbinin DS; Zharkova MS; Tkachev YV; Timofeev VP; Veselovsky AV; Shumyantseva VV; Misharin AY
    Steroids; 2014 Oct; 88():66-71. PubMed ID: 24971814
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Prospective computational design and in vitro bio-analytical tests of new chemical entities as potential selective CYP17A1 lyase inhibitors.
    Gumede NJ; Nxumalo W; Bisetty K; Escuder Gilabert L; Medina-Hernandez MJ; Sagrado S
    Bioorg Chem; 2020 Jan; 94():103462. PubMed ID: 31818479
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structure-Based Design of Inhibitors with Improved Selectivity for Steroidogenic Cytochrome P450 17A1 over Cytochrome P450 21A2.
    Fehl C; Vogt CD; Yadav R; Li K; Scott EE; Aubé J
    J Med Chem; 2018 Jun; 61(11):4946-4960. PubMed ID: 29792703
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Pregnenolonyl-α-glucoside exhibits marked anti-cancer and CYP17A1 enzymatic inhibitory activities.
    Chou FP; Hsu WC; Huang SC; Chang CY; Chiou YS; Tsai CT; Lyu JW; Chen WT; Wu TK
    Chem Commun (Camb); 2020 Feb; 56(11):1733-1736. PubMed ID: 31938799
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synthesis, 17α-hydroxylase-C
    Banday AH; Shameem SA; Banday JA; Ganaie BA
    Anticancer Agents Med Chem; 2018; 18(13):1919-1926. PubMed ID: 29697032
    [TBL] [Abstract][Full Text] [Related]  

  • 10. 17-Hydroxylase and andien-beta synthetase activities in immature pig testis microsomal fraction: kinetic studies of the pregnenolone binding site and possible intermediates of the reactions.
    Lavallée J; Cooke GM
    J Steroid Biochem Mol Biol; 1993 Jul; 46(1):73-83. PubMed ID: 8338793
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Three dimensional pharmacophore modeling of human CYP17 inhibitors. Potential agents for prostate cancer therapy.
    Clement OO; Freeman CM; Hartmann RW; Handratta VD; Vasaitis TS; Brodie AM; Njar VC
    J Med Chem; 2003 Jun; 46(12):2345-51. PubMed ID: 12773039
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Exploiting the Chromone Scaffold for the Development of Inhibitors of Corticosteroid Biosynthesis.
    Gobbi S; Hu Q; Zimmer C; Engel M; Belluti F; Rampa A; Hartmann RW; Bisi A
    J Med Chem; 2016 Mar; 59(6):2468-77. PubMed ID: 26938274
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Novel functionalized 5-(phenoxymethyl)-1,3-dioxane analogs exhibiting cytochrome P450 inhibition: a patent evaluation WO2015048311 (A1).
    Schroeder RL; Tram P; Liu J; Foroozesh M; Sridhar J
    Expert Opin Ther Pat; 2016; 26(1):139-47. PubMed ID: 26514241
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Synthesis and evaluation of novel steroidal oxime inhibitors of P450 17 (17 alpha-hydroxylase/C17-20-lyase) and 5 alpha-reductase types 1 and 2.
    Hartmann RW; Hector M; Haidar S; Ehmer PB; Reichert W; Jose J
    J Med Chem; 2000 Nov; 43(22):4266-77. PubMed ID: 11063622
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Synthesis and evaluation of 17-aliphatic heterocycle-substituted steroidal inhibitors of 17alpha-hydroxylase/C17-20-lyase (P450 17).
    Hartmann RW; Hector M; Wachall BG; Palusczak A; Palzer M; Huch V; Veith M
    J Med Chem; 2000 Nov; 43(23):4437-45. PubMed ID: 11087568
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Synthesis, biological evaluation, and molecular modeling of abiraterone analogues: novel CYP17 inhibitors for the treatment of prostate cancer.
    Pinto-Bazurco Mendieta MA; Negri M; Jagusch C; Müller-Vieira U; Lauterbach T; Hartmann RW
    J Med Chem; 2008 Aug; 51(16):5009-18. PubMed ID: 18672868
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Illuminating cytochrome P450 binding: Ru(ii)-caged inhibitors of CYP17A1.
    Li A; Yadav R; White JK; Herroon MK; Callahan BP; Podgorski I; Turro C; Scott EE; Kodanko JJ
    Chem Commun (Camb); 2017 Mar; 53(26):3673-3676. PubMed ID: 28304025
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Computational prediction of new CYP17 inhibitors based on pharmacophore modeling, virtual screening and docking approach.
    Haidar S; Hartmann RW
    Pharmazie; 2017 Sep; 72(9):529-536. PubMed ID: 29441980
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Design and synthesis of functionalized piperazin-1yl-(E)-stilbenes as inhibitors of 17α-hydroxylase-C17,20-lyase (Cyp17).
    Blass BE; Iyer P; Abou-Gharbia M; Childers WE; Gordon JC; Ramanjulu M; Morton G; Arumugam P; Boruwa J; Ellingboe J; Mitra S; Reddy Nimmareddy R; Paliwal S; Rajasekhar J; Shivakumar S; Srivastava P; Tangirala RS; Venkataramanaiah K; Bobbala R; Yanamandra M; Krishnakanth Reddy L
    Bioorg Med Chem Lett; 2018 Jul; 28(13):2270-2274. PubMed ID: 29803730
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Highly-selective 4-(1,2,3-triazole)-based P450c17a 17,20-lyase inhibitors.
    Rafferty SW; Eisner JR; Moore WR; Schotzinger RJ; Hoekstra WJ
    Bioorg Med Chem Lett; 2014 Jun; 24(11):2444-7. PubMed ID: 24775307
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.