These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

303 related articles for article (PubMed ID: 25257175)

  • 1. Calpain inhibition mediates autophagy-dependent protection against polyglutamine toxicity.
    Menzies FM; Garcia-Arencibia M; Imarisio S; O'Sullivan NC; Ricketts T; Kent BA; Rao MV; Lam W; Green-Thompson ZW; Nixon RA; Saksida LM; Bussey TJ; O'Kane CJ; Rubinsztein DC
    Cell Death Differ; 2015 Mar; 22(3):433-44. PubMed ID: 25257175
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Calpastatin ablation aggravates the molecular phenotype in cell and animal models of Huntington disease.
    Weber JJ; Kloock SJ; Nagel M; Ortiz-Rios MM; Hofmann J; Riess O; Nguyen HP
    Neuropharmacology; 2018 May; 133():94-106. PubMed ID: 29355642
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Olesoxime suppresses calpain activation and mutant huntingtin fragmentation in the BACHD rat.
    Clemens LE; Weber JJ; Wlodkowski TT; Yu-Taeger L; Michaud M; Calaminus C; Eckert SH; Gaca J; Weiss A; Magg JC; Jansson EK; Eckert GP; Pichler BJ; Bordet T; Pruss RM; Riess O; Nguyen HP
    Brain; 2015 Dec; 138(Pt 12):3632-53. PubMed ID: 26490331
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Calpain and STriatal-Enriched protein tyrosine phosphatase (STEP) activation contribute to extrasynaptic NMDA receptor localization in a Huntington's disease mouse model.
    Gladding CM; Sepers MD; Xu J; Zhang LY; Milnerwood AJ; Lombroso PJ; Raymond LA
    Hum Mol Genet; 2012 Sep; 21(17):3739-52. PubMed ID: 22523092
    [TBL] [Abstract][Full Text] [Related]  

  • 5. AUTEN-67 (Autophagy Enhancer-67) Hampers the Progression of Neurodegenerative Symptoms in a Drosophila model of Huntington's Disease.
    Billes V; Kovács T; Hotzi B; Manzéger A; Tagscherer K; Komlós M; Tarnóci A; Pádár Z; Erdős A; Bjelik A; Legradi A; Gulya K; Gulyás B; Vellai T
    J Huntingtons Dis; 2016 May; 5(2):133-47. PubMed ID: 27163946
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Calpastatin-mediated inhibition of calpains in the mouse brain prevents mutant ataxin 3 proteolysis, nuclear localization and aggregation, relieving Machado-Joseph disease.
    Simões AT; Gonçalves N; Koeppen A; Déglon N; Kügler S; Duarte CB; Pereira de Almeida L
    Brain; 2012 Aug; 135(Pt 8):2428-39. PubMed ID: 22843411
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies.
    Sarkar S; Ravikumar B; Floto RA; Rubinsztein DC
    Cell Death Differ; 2009 Jan; 16(1):46-56. PubMed ID: 18636076
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Polyglutamine-modulated striatal calpain activity in YAC transgenic huntington disease mouse model: impact on NMDA receptor function and toxicity.
    Cowan CM; Fan MM; Fan J; Shehadeh J; Zhang LY; Graham RK; Hayden MR; Raymond LA
    J Neurosci; 2008 Nov; 28(48):12725-35. PubMed ID: 19036965
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleus.
    Gafni J; Hermel E; Young JE; Wellington CL; Hayden MR; Ellerby LM
    J Biol Chem; 2004 May; 279(19):20211-20. PubMed ID: 14981075
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Downregulation of glial genes involved in synaptic function mitigates Huntington's disease pathogenesis.
    Onur TS; Laitman A; Zhao H; Keyho R; Kim H; Wang J; Mair M; Wang H; Li L; Perez A; de Haro M; Wan YW; Allen G; Lu B; Al-Ramahi I; Liu Z; Botas J
    Elife; 2021 Apr; 10():. PubMed ID: 33871358
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Polyglutamine tracts regulate beclin 1-dependent autophagy.
    Ashkenazi A; Bento CF; Ricketts T; Vicinanza M; Siddiqi F; Pavel M; Squitieri F; Hardenberg MC; Imarisio S; Menzies FM; Rubinsztein DC
    Nature; 2017 May; 545(7652):108-111. PubMed ID: 28445460
    [TBL] [Abstract][Full Text] [Related]  

  • 12. A calpain-like activity insensitive to calpastatin in Drosophila melanogaster.
    Laval M; Pascal M
    Biochim Biophys Acta; 2002 Mar; 1570(2):121-8. PubMed ID: 11985896
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Alterations in STriatal-Enriched protein tyrosine Phosphatase expression, activation, and downstream signaling in early and late stages of the YAC128 Huntington's disease mouse model.
    Gladding CM; Fan J; Zhang LY; Wang L; Xu J; Li EH; Lombroso PJ; Raymond LA
    J Neurochem; 2014 Jul; 130(1):145-59. PubMed ID: 24588402
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Calpain is a major cell death effector in selective striatal degeneration induced in vivo by 3-nitropropionate: implications for Huntington's disease.
    Bizat N; Hermel JM; Boyer F; Jacquard C; Créminon C; Ouary S; Escartin C; Hantraye P; Kajewski S; Brouillet E
    J Neurosci; 2003 Jun; 23(12):5020-30. PubMed ID: 12832525
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Overexpression of the calpain-specific inhibitor calpastatin reduces human alpha-Synuclein processing, aggregation and synaptic impairment in [A30P]αSyn transgenic mice.
    Diepenbroek M; Casadei N; Esmer H; Saido TC; Takano J; Kahle PJ; Nixon RA; Rao MV; Melki R; Pieri L; Helling S; Marcus K; Krueger R; Masliah E; Riess O; Nuber S
    Hum Mol Genet; 2014 Aug; 23(15):3975-89. PubMed ID: 24619358
    [TBL] [Abstract][Full Text] [Related]  

  • 16. α-Synuclein levels affect autophagosome numbers in vivo and modulate Huntington disease pathology.
    Corrochano S; Renna M; Tomas-Zapico C; Brown SD; Lucas JJ; Rubinsztein DC; Acevedo-Arozena A
    Autophagy; 2012 Mar; 8(3):431-2. PubMed ID: 22361581
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Deletion of the huntingtin polyglutamine stretch enhances neuronal autophagy and longevity in mice.
    Zheng S; Clabough EB; Sarkar S; Futter M; Rubinsztein DC; Zeitlin SO
    PLoS Genet; 2010 Feb; 6(2):e1000838. PubMed ID: 20140187
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Distinct roles for Toll and autophagy pathways in double-stranded RNA toxicity in a Drosophila model of expanded repeat neurodegenerative diseases.
    Samaraweera SE; O'Keefe LV; Price GR; Venter DJ; Richards RI
    Hum Mol Genet; 2013 Jul; 22(14):2811-9. PubMed ID: 23525903
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease.
    Ravikumar B; Vacher C; Berger Z; Davies JE; Luo S; Oroz LG; Scaravilli F; Easton DF; Duden R; O'Kane CJ; Rubinsztein DC
    Nat Genet; 2004 Jun; 36(6):585-95. PubMed ID: 15146184
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Calpastatin overexpression limits calpain-mediated proteolysis and behavioral deficits following traumatic brain injury.
    Schoch KM; Evans HN; Brelsfoard JM; Madathil SK; Takano J; Saido TC; Saatman KE
    Exp Neurol; 2012 Aug; 236(2):371-82. PubMed ID: 22572592
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 16.