These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

474 related articles for article (PubMed ID: 25263519)

  • 1. Identification of a novel inhibitor of dengue virus protease through use of a virtual screening drug discovery Web portal.
    Viswanathan U; Tomlinson SM; Fonner JM; Mock SA; Watowich SJ
    J Chem Inf Model; 2014 Oct; 54(10):2816-25. PubMed ID: 25263519
    [TBL] [Abstract][Full Text] [Related]  

  • 2. 3D-QSAR pharmacophore-based virtual screening, molecular docking and molecular dynamics simulation toward identifying lead compounds for NS2B-NS3 protease inhibitors.
    Luo PH; Zhang XR; Huang L; Yuan L; Zhou XZ; Gao X; Li LS
    J Recept Signal Transduct Res; 2017 Oct; 37(5):481-492. PubMed ID: 28758854
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Use of parallel validation high-throughput screens to reduce false positives and identify novel dengue NS2B-NS3 protease inhibitors.
    Tomlinson SM; Watowich SJ
    Antiviral Res; 2012 Feb; 93(2):245-252. PubMed ID: 22193283
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus.
    Erbel P; Schiering N; D'Arcy A; Renatus M; Kroemer M; Lim SP; Yin Z; Keller TH; Vasudevan SG; Hommel U
    Nat Struct Mol Biol; 2006 Apr; 13(4):372-3. PubMed ID: 16532006
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Simultaneous uncoupled expression and purification of the Dengue virus NS3 protease and NS2B co-factor domain.
    Shannon AE; Chappell KJ; Stoermer MJ; Chow SY; Kok WM; Fairlie DP; Young PR
    Protein Expr Purif; 2016 Mar; 119():124-9. PubMed ID: 26647367
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Conformational flexibility of DENV NS2B/NS3pro: from the inhibitor effect to the serotype influence.
    Piccirillo E; Merget B; Sotriffer CA; do Amaral AT
    J Comput Aided Mol Des; 2016 Mar; 30(3):251-70. PubMed ID: 26923377
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Homology modeling and molecular dynamics simulations of Dengue virus NS2B/NS3 protease: insight into molecular interaction.
    Wichapong K; Pianwanit S; Sippl W; Kokpol S
    J Mol Recognit; 2010; 23(3):283-300. PubMed ID: 19693793
    [TBL] [Abstract][Full Text] [Related]  

  • 8. A straightforward experimental approach to expression, purification, refolding, and enzymatic analysis of recombinant dengue virus NS2B(H)-NS3pro protease.
    Junaid M; Angsuthanasombat C; Wikberg JE; Ali N; Katzenmeier G
    Biochemistry (Mosc); 2013 Aug; 78(8):920-4. PubMed ID: 24228881
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Intrinsic flexibility of West Nile virus protease in solution characterized using small-angle X-ray scattering.
    Garces AP; Watowich SJ
    Biochemistry; 2013 Oct; 52(39):6856-65. PubMed ID: 24015950
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Characterization of the West Nile virus protease substrate specificity and inhibitors.
    Mueller NH; Yon C; Ganesh VK; Padmanabhan R
    Int J Biochem Cell Biol; 2007; 39(3):606-14. PubMed ID: 17188926
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Transplantation of a hydrogen bonding network from West Nile virus protease onto Dengue-2 protease improves catalytic efficiency and sheds light on substrate specificity.
    Doan DN; Li KQ; Basavannacharya C; Vasudevan SG; Madhusudhan MS
    Protein Eng Des Sel; 2012 Dec; 25(12):843-50. PubMed ID: 22972763
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Homology modeling and molecular dynamics study of West Nile virus NS3 protease: a molecular basis for the catalytic activity increased by the NS2B cofactor.
    Zhou H; Singh NJ; Kim KS
    Proteins; 2006 Nov; 65(3):692-701. PubMed ID: 16972281
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Product release is rate-limiting for catalytic processing by the Dengue virus protease.
    Shannon AE; Pedroso MM; Chappell KJ; Watterson D; Liebscher S; Kok WM; Fairlie DP; Schenk G; Young PR
    Sci Rep; 2016 Nov; 6():37539. PubMed ID: 27897196
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Discovery of novel small molecule inhibitors of dengue viral NS2B-NS3 protease using virtual screening and scaffold hopping.
    Deng J; Li N; Liu H; Zuo Z; Liew OW; Xu W; Chen G; Tong X; Tang W; Zhu J; Zuo J; Jiang H; Yang CG; Li J; Zhu W
    J Med Chem; 2012 Jul; 55(14):6278-93. PubMed ID: 22742496
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Virtual ligand screening of the National Cancer Institute (NCI) compound library leads to the allosteric inhibitory scaffolds of the West Nile Virus NS3 proteinase.
    Shiryaev SA; Cheltsov AV; Gawlik K; Ratnikov BI; Strongin AY
    Assay Drug Dev Technol; 2011 Feb; 9(1):69-78. PubMed ID: 21050032
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Binding specificity of polypeptide substrates in NS2B/NS3pro serine protease of dengue virus type 2: A molecular dynamics Study.
    Yotmanee P; Rungrotmongkol T; Wichapong K; Choi SB; Wahab HA; Kungwan N; Hannongbua S
    J Mol Graph Model; 2015 Jul; 60():24-33. PubMed ID: 26086900
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Mechanism of NS2B-mediated activation of NS3pro in dengue virus: molecular dynamics simulations and bioassays.
    Zuo Z; Liew OW; Chen G; Chong PC; Lee SH; Chen K; Jiang H; Puah CM; Zhu W
    J Virol; 2009 Jan; 83(2):1060-70. PubMed ID: 18971276
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Binding of low molecular weight inhibitors promotes large conformational changes in the dengue virus NS2B-NS3 protease: fold analysis by pseudocontact shifts.
    de la Cruz L; Nguyen TH; Ozawa K; Shin J; Graham B; Huber T; Otting G
    J Am Chem Soc; 2011 Nov; 133(47):19205-15. PubMed ID: 22007671
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Structure-guided Discovery of a Novel Non-peptide Inhibitor of Dengue Virus NS2B-NS3 Protease.
    Li L; Basavannacharya C; Chan KW; Shang L; Vasudevan SG; Yin Z
    Chem Biol Drug Des; 2015 Sep; 86(3):255-64. PubMed ID: 25533891
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Structural Insights into the Inhibition of Zika Virus NS2B-NS3 Protease by a Small-Molecule Inhibitor.
    Li Y; Zhang Z; Phoo WW; Loh YR; Li R; Yang HY; Jansson AE; Hill J; Keller TH; Nacro K; Luo D; Kang C
    Structure; 2018 Apr; 26(4):555-564.e3. PubMed ID: 29526431
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 24.