BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

155 related articles for article (PubMed ID: 25267004)

  • 21. The Quest for the Best Dual Orexin Receptor Antagonist (Daridorexant) for the Treatment of Insomnia Disorders.
    Boss C; Gatfield J; Brotschi C; Heidmann B; Sifferlen T; von Raumer M; Schmidt G; Williams JT; Treiber A; Roch C
    ChemMedChem; 2020 Dec; 15(23):2286-2305. PubMed ID: 32937014
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Structure-activity relationship, biological, and pharmacological characterization of the proline sulfonamide ACT-462206: a potent, brain-penetrant dual orexin 1/orexin 2 receptor antagonist.
    Boss C; Roch-Brisbare C; Steiner MA; Treiber A; Dietrich H; Jenck F; von Raumer M; Sifferlen T; Brotschi C; Heidmann B; Williams JT; Aissaoui H; Siegrist R; Gatfield J
    ChemMedChem; 2014 Nov; 9(11):2486-96. PubMed ID: 25147058
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Orexin Receptor Antagonists: New Therapeutic Agents for the Treatment of Insomnia.
    Roecker AJ; Cox CD; Coleman PJ
    J Med Chem; 2016 Jan; 59(2):504-30. PubMed ID: 26317591
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Identification of highly selective and potent orexin receptor 1 antagonists derived from a dual orexin receptor 1/2 antagonist based on the structural framework of pyrazoylethylbenzamide.
    Futamura A; Nozawa D; Araki Y; Tamura Y; Tokura S; Kawamoto H; Tokumaru Y; Kakihara S; Aoki T; Ohtake N
    Bioorg Med Chem; 2017 Oct; 25(20):5203-5215. PubMed ID: 28807572
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Oxadiazole Derivatives as Dual Orexin Receptor Antagonists: Synthesis, Structure-Activity Relationships, and Sleep-Promoting Properties in Rats.
    Brotschi C; Roch C; Gatfield J; Treiber A; Williams JT; Sifferlen T; Heidmann B; Jenck F; Bolli MH; Boss C
    ChemMedChem; 2019 Jul; 14(13):1257-1270. PubMed ID: 31066976
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Structure-activity relationship studies and sleep-promoting activity of novel 1-chloro-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine derivatives as dual orexin receptor antagonists. Part 2.
    Sifferlen T; Koberstein R; Cottreel E; Boller A; Weller T; Gatfield J; Brisbare-Roch C; Jenck F; Boss C
    Bioorg Med Chem Lett; 2013 Jul; 23(13):3857-63. PubMed ID: 23719231
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Orexin receptor antagonists: medicinal chemistry and therapeutic potential.
    Roecker AJ; Coleman PJ
    Curr Top Med Chem; 2008; 8(11):977-87. PubMed ID: 18673167
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Synthesis and evaluation of carbon-linked analogs of dual orexin receptor antagonist filorexant.
    Kuduk SD; Skudlarek JW; Di Marco CN; Bruno JG; Pausch MA; O'Brien JA; Cabalu TD; Stevens J; Brunner J; Tannenbaum PL; Gotter AL; Winrow CJ; Renger JJ; Coleman PJ
    Bioorg Med Chem Lett; 2014 Apr; 24(7):1784-9. PubMed ID: 24630562
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Discovery of Highly Potent Dual Orexin Receptor Antagonists via a Scaffold-Hopping Approach.
    Heidmann B; Gatfield J; Roch C; Treiber A; Tortoioli S; Brotschi C; Williams JT; Bolli MH; Abele S; Sifferlen T; Jenck F; Boss C
    ChemMedChem; 2016 Oct; 11(19):2132-2146. PubMed ID: 27390287
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Suvorexant: something new for sleep?
    Reddy A; Puvvada SC; Kommisetti S; El-Mallakh RS; Lippmann S
    Acta Neuropsychiatr; 2015 Feb; 27(1):53-5. PubMed ID: 25397996
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Selective orexin receptor antagonists.
    Lebold TP; Bonaventure P; Shireman BT
    Bioorg Med Chem Lett; 2013 Sep; 23(17):4761-9. PubMed ID: 23891187
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Discovery of dual orexin receptor antagonists with rat sleep efficacy enabled by expansion of the acetonitrile-assisted/diphosgene-mediated 2,4-dichloropyrimidine synthesis.
    Roecker AJ; Mercer SP; Harrell CM; Garson SL; Fox SV; Gotter AL; Prueksaritanont T; Cabalu TD; Cui D; Lemaire W; Winrow CJ; Renger JJ; Coleman PJ
    Bioorg Med Chem Lett; 2014 May; 24(9):2079-85. PubMed ID: 24704030
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Discovery of substituted lactams as novel dual orexin receptor antagonists. Synthesis, preliminary structure-activity relationship studies and efforts towards improved metabolic stability and pharmacokinetic properties. Part 1.
    Sifferlen T; Boller A; Chardonneau A; Cottreel E; Hoecker J; Aissaoui H; Williams JT; Brotschi C; Heidmann B; Siegrist R; Gatfield J; Treiber A; Brisbare-Roch C; Jenck F; Boss C
    Bioorg Med Chem Lett; 2014 Feb; 24(4):1201-8. PubMed ID: 24447850
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Suvorexant for the treatment of insomnia.
    Jacobson LH; Callander GE; Hoyer D
    Expert Rev Clin Pharmacol; 2014 Nov; 7(6):711-30. PubMed ID: 25318834
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant.
    Yin J; Mobarec JC; Kolb P; Rosenbaum DM
    Nature; 2015 Mar; 519(7542):247-50. PubMed ID: 25533960
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Orexin receptors: multi-functional therapeutic targets for sleeping disorders, eating disorders, drug addiction, cancers and other physiological disorders.
    Xu TR; Yang Y; Ward R; Gao L; Liu Y
    Cell Signal; 2013 Dec; 25(12):2413-23. PubMed ID: 23917208
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Discovery of novel substituted octahydropyrrolo[3,4-c]pyrroles as dual orexin receptor antagonists for insomnia treatment.
    Wu S; Sun Y; Hu Y; Zhang H; Hou L; Liu X; Li Y; He H; Luo Z; Chen Y; Wang Y; Shi W; Shen L; Cao C; Liang W; Xu Q; Lv Q; Lan J; Li J; Chen S
    Bioorg Med Chem Lett; 2017 Mar; 27(6):1458-1462. PubMed ID: 28216404
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Orexin receptor antagonism for treatment of insomnia: a randomized clinical trial of suvorexant.
    Herring WJ; Snyder E; Budd K; Hutzelmann J; Snavely D; Liu K; Lines C; Roth T; Michelson D
    Neurology; 2012 Dec; 79(23):2265-74. PubMed ID: 23197752
    [TBL] [Abstract][Full Text] [Related]  

  • 39. From Oxadiazole to Triazole Analogues: Optimization toward a Dual Orexin Receptor Antagonist with Improved in vivo Efficacy in Dogs.
    Brotschi C; Bolli MH; Gatfield J; Heidmann B; Jenck F; Roch C; Sifferlen T; Treiber A; Williams JT; Boss C
    ChemMedChem; 2020 Mar; 15(5):430-448. PubMed ID: 31945272
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Dual orexin receptor antagonists - promising agents in the treatment of sleep disorders.
    Pałasz A; Lapray D; Peyron C; Rojczyk-Gołębiewska E; Skowronek R; Markowski G; Czajkowska B; Krzystanek M; Wiaderkiewicz R
    Int J Neuropsychopharmacol; 2014 Jan; 17(1):157-68. PubMed ID: 23702225
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 8.