BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

205 related articles for article (PubMed ID: 25275007)

  • 1. Investigating the role of a backbone to substrate hydrogen bond in OMP decarboxylase using a site-specific amide to ester substitution.
    Desai BJ; Goto Y; Cembran A; Fedorov AA; Almo SC; Gao J; Suga H; Gerlt JA
    Proc Natl Acad Sci U S A; 2014 Oct; 111(42):15066-71. PubMed ID: 25275007
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Rate and Equilibrium Constants for an Enzyme Conformational Change during Catalysis by Orotidine 5'-Monophosphate Decarboxylase.
    Goryanova B; Goldman LM; Ming S; Amyes TL; Gerlt JA; Richard JP
    Biochemistry; 2015 Jul; 54(29):4555-64. PubMed ID: 26135041
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Evolution of enzymatic activities in the orotidine 5'-monophosphate decarboxylase suprafamily: mechanistic evidence for a proton relay system in the active site of 3-keto-L-gulonate 6-phosphate decarboxylase.
    Yew WS; Wise EL; Rayment I; Gerlt JA
    Biochemistry; 2004 Jun; 43(21):6427-37. PubMed ID: 15157077
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Mechanism of the orotidine 5'-monophosphate decarboxylase-catalyzed reaction: importance of residues in the orotate binding site.
    Iiams V; Desai BJ; Fedorov AA; Fedorov EV; Almo SC; Gerlt JA
    Biochemistry; 2011 Oct; 50(39):8497-507. PubMed ID: 21870810
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Mechanism of the orotidine 5'-monophosphate decarboxylase-catalyzed reaction: evidence for substrate destabilization.
    Chan KK; Wood BM; Fedorov AA; Fedorov EV; Imker HJ; Amyes TL; Richard JP; Almo SC; Gerlt JA
    Biochemistry; 2009 Jun; 48(24):5518-31. PubMed ID: 19435314
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Study of orotidine 5'-monophosphate decarboxylase in complex with the top three OMP, BMP, and PMP ligands by molecular dynamics simulation.
    Jamshidi S; Jalili S; Rafii-Tabar H
    J Biomol Struct Dyn; 2015; 33(2):404-17. PubMed ID: 24559040
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Electrostatic stress in catalysis: structure and mechanism of the enzyme orotidine monophosphate decarboxylase.
    Wu N; Mo Y; Gao J; Pai EF
    Proc Natl Acad Sci U S A; 2000 Feb; 97(5):2017-22. PubMed ID: 10681441
    [TBL] [Abstract][Full Text] [Related]  

  • 8. An examination of the relationship between active site loop size and thermodynamic activation parameters for orotidine 5'-monophosphate decarboxylase from mesophilic and thermophilic organisms.
    Toth K; Amyes TL; Wood BM; Chan KK; Gerlt JA; Richard JP
    Biochemistry; 2009 Aug; 48(33):8006-13. PubMed ID: 19618917
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Dissecting the total transition state stabilization provided by amino acid side chains at orotidine 5'-monophosphate decarboxylase: a two-part substrate approach.
    Barnett SA; Amyes TL; Wood BM; Gerlt JA; Richard JP
    Biochemistry; 2008 Jul; 47(30):7785-7. PubMed ID: 18598058
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Mechanism of the orotidine 5'-monophosphate decarboxylase-catalyzed reaction: effect of solvent viscosity on kinetic constants.
    Wood BM; Chan KK; Amyes TL; Richard JP; Gerlt JA
    Biochemistry; 2009 Jun; 48(24):5510-7. PubMed ID: 19435313
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Molecular dynamic study of orotidine-5'-monophosphate decarboxylase in ground state and in intermediate state: a role of the 203-218 loop dynamics.
    Hur S; Bruice TC
    Proc Natl Acad Sci U S A; 2002 Jul; 99(15):9668-73. PubMed ID: 12107279
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Structural basis for the catalytic mechanism of a proficient enzyme: orotidine 5'-monophosphate decarboxylase.
    Harris P; Navarro Poulsen JC; Jensen KF; Larsen S
    Biochemistry; 2000 Apr; 39(15):4217-24. PubMed ID: 10757968
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Toward assessing the position-dependent contributions of backbone hydrogen bonding to beta-sheet folding thermodynamics employing amide-to-ester perturbations.
    Deechongkit S; Dawson PE; Kelly JW
    J Am Chem Soc; 2004 Dec; 126(51):16762-71. PubMed ID: 15612714
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Orotidine 5'-Monophosphate Decarboxylase: Probing the Limits of the Possible for Enzyme Catalysis.
    Richard JP; Amyes TL; Reyes AC
    Acc Chem Res; 2018 Apr; 51(4):960-969. PubMed ID: 29595949
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Mechanism of OMP decarboxylation in orotidine 5'-monophosphate decarboxylase.
    Hu H; Boone A; Yang W
    J Am Chem Soc; 2008 Nov; 130(44):14493-503. PubMed ID: 18839943
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The crystal structure and mechanism of orotidine 5'-monophosphate decarboxylase.
    Appleby TC; Kinsland C; Begley TP; Ealick SE
    Proc Natl Acad Sci U S A; 2000 Feb; 97(5):2005-10. PubMed ID: 10681442
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Conformational changes in orotidine 5'-monophosphate decarboxylase: "remote" residues that stabilize the active conformation.
    Wood BM; Amyes TL; Fedorov AA; Fedorov EV; Shabila A; Almo SC; Richard JP; Gerlt JA
    Biochemistry; 2010 May; 49(17):3514-6. PubMed ID: 20369850
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The structural basis for the remarkable catalytic proficiency of orotidine 5'-monophosphate decarboxylase.
    Begley TP; Appleby TC; Ealick SE
    Curr Opin Struct Biol; 2000 Dec; 10(6):711-8. PubMed ID: 11114509
    [TBL] [Abstract][Full Text] [Related]  

  • 19. An alternative explanation for the catalytic proficiency of orotidine 5'-phosphate decarboxylase.
    Lee TS; Chong LT; Chodera JD; Kollman PA
    J Am Chem Soc; 2001 Dec; 123(51):12837-48. PubMed ID: 11749542
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Role of the Carboxylate in Enzyme-Catalyzed Decarboxylation of Orotidine 5'-Monophosphate: Transition State Stabilization Dominates Over Ground State Destabilization.
    Goryanova B; Amyes TL; Richard JP
    J Am Chem Soc; 2019 Aug; 141(34):13468-13478. PubMed ID: 31365243
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.