BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

148 related articles for article (PubMed ID: 25277206)

  • 1. FAK inhibition with small molecule inhibitor Y15 decreases viability, clonogenicity, and cell attachment in thyroid cancer cell lines and synergizes with targeted therapeutics.
    O'Brien S; Golubovskaya VM; Conroy J; Liu S; Wang D; Liu B; Cance WG
    Oncotarget; 2014 Sep; 5(17):7945-59. PubMed ID: 25277206
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Down-regulation of ALDH1A3, CD44 or MDR1 sensitizes resistant cancer cells to FAK autophosphorylation inhibitor Y15.
    Golubovskaya V; O'Brien S; Ho B; Heffler M; Conroy J; Hu Q; Wang D; Liu S; Cance WG
    J Cancer Res Clin Oncol; 2015 Sep; 141(9):1613-31. PubMed ID: 25656374
    [TBL] [Abstract][Full Text] [Related]  

  • 3. FAK and HAS inhibition synergistically decrease colon cancer cell viability and affect expression of critical genes.
    Heffler M; Golubovskaya VM; Conroy J; Liu S; Wang D; Cance WG; Dunn KB
    Anticancer Agents Med Chem; 2013 May; 13(4):584-94. PubMed ID: 22934709
    [TBL] [Abstract][Full Text] [Related]  

  • 4. A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer.
    Hochwald SN; Nyberg C; Zheng M; Zheng D; Wood C; Massoll NA; Magis A; Ostrov D; Cance WG; Golubovskaya VM
    Cell Cycle; 2009 Aug; 8(15):2435-43. PubMed ID: 19571674
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Pharmacologic blockade of FAK autophosphorylation decreases human glioblastoma tumor growth and synergizes with temozolomide.
    Golubovskaya VM; Huang G; Ho B; Yemma M; Morrison CD; Lee J; Eliceiri BP; Cance WG
    Mol Cancer Ther; 2013 Feb; 12(2):162-72. PubMed ID: 23243059
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Focal adhesion kinase autophosphorylation inhibition decreases colon cancer cell growth and enhances the efficacy of chemotherapy.
    Heffler M; Golubovskaya VM; Dunn KM; Cance W
    Cancer Biol Ther; 2013 Aug; 14(8):761-72. PubMed ID: 23792569
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Targeting Focal Adhesion Kinase and Resistance to mTOR Inhibition in Pancreatic Neuroendocrine Tumors.
    François RA; Maeng K; Nawab A; Kaye FJ; Hochwald SN; Zajac-Kaye M
    J Natl Cancer Inst; 2015 Aug; 107(8):. PubMed ID: 25971297
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Efficacy of focal adhesion kinase inhibition in non-small cell lung cancer with oncogenically activated MAPK pathways.
    Zhang H; Shao H; Golubovskaya VM; Chen H; Cance W; Adjei AA; Dy GK
    Br J Cancer; 2016 Jul; 115(2):203-11. PubMed ID: 27336608
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The microarray gene profiling analysis of glioblastoma cancer cells reveals genes affected by FAK inhibitor Y15 and combination of Y15 and temozolomide.
    Huang G; Ho B; Conroy J; Liu S; Qiang H; Golubovskaya V
    Anticancer Agents Med Chem; 2014 Jan; 14(1):9-17. PubMed ID: 23387973
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Focal Adhesion Kinase Inhibitor Inhibits the Oxidative Damage Induced by Central Venous Catheter via Abolishing Focal Adhesion Kinase-Protein Kinase B Pathway Activation.
    Wang Y; Lin S; Jiang P; Song Y; Zhao Y; Zheng Y
    Biomed Res Int; 2021; 2021():6685493. PubMed ID: 33748278
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Focal adhesion kinase a potential therapeutic target for pancreatic cancer and malignant pleural mesothelioma.
    Kanteti R; Mirzapoiazova T; Riehm JJ; Dhanasingh I; Mambetsariev B; Wang J; Kulkarni P; Kaushik G; Seshacharyulu P; Ponnusamy MP; Kindler HL; Nasser MW; Batra SK; Salgia R
    Cancer Biol Ther; 2018 Apr; 19(4):316-327. PubMed ID: 29303405
    [TBL] [Abstract][Full Text] [Related]  

  • 12. A small molecule focal adhesion kinase (FAK) inhibitor, targeting Y397 site: 1-(2-hydroxyethyl)-3, 5, 7-triaza-1-azoniatricyclo [3.3.1.1(3,7)]decane; bromide effectively inhibits FAK autophosphorylation activity and decreases cancer cell viability, clonogenicity and tumor growth in vivo.
    Golubovskaya VM; Figel S; Ho BT; Johnson CP; Yemma M; Huang G; Zheng M; Nyberg C; Magis A; Ostrov DA; Gelman IH; Cance WG
    Carcinogenesis; 2012 May; 33(5):1004-13. PubMed ID: 22402131
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Inhibition of focal adhesion kinase decreases tumor growth in human neuroblastoma.
    Beierle EA; Ma X; Stewart J; Nyberg C; Trujillo A; Cance WG; Golubovskaya VM
    Cell Cycle; 2010 Mar; 9(5):1005-15. PubMed ID: 20160475
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Small-molecule inhibitors of FGFR, integrins and FAK selectively decrease L1CAM-stimulated glioblastoma cell motility and proliferation.
    Anderson HJ; Galileo DS
    Cell Oncol (Dordr); 2016 Jun; 39(3):229-42. PubMed ID: 26883759
    [TBL] [Abstract][Full Text] [Related]  

  • 15. In vivo toxicity, metabolism and pharmacokinetic properties of FAK inhibitor 14 or Y15 (1, 2, 4, 5-benzenetetramine tetrahydrochloride).
    Golubovskaya V; Curtin L; Groman A; Sexton S; Cance WG
    Arch Toxicol; 2015 Jul; 89(7):1095-101. PubMed ID: 24915938
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Therapeutic Potential of Focal Adhesion Kinase Inhibition in Small Cell Lung Cancer.
    Aboubakar Nana F; Lecocq M; Ladjemi MZ; Detry B; Dupasquier S; Feron O; Massion PP; Sibille Y; Pilette C; Ocak S
    Mol Cancer Ther; 2019 Jan; 18(1):17-27. PubMed ID: 30352800
    [TBL] [Abstract][Full Text] [Related]  

  • 17. A novel combination of withaferin A and sorafenib shows synergistic efficacy against both papillary and anaplastic thyroid cancers.
    Cohen SM; Mukerji R; Timmermann BN; Samadi AK; Cohen MS
    Am J Surg; 2012 Dec; 204(6):895-900; discussion 900-1. PubMed ID: 23231932
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Focal Adhesion Kinase Inhibition Contributes to Tumor Cell Survival and Motility in Neuroblastoma Patient-Derived Xenografts.
    Stafman LL; Williams AP; Marayati R; Aye JM; Markert HR; Garner EF; Quinn CH; Lallani SB; Stewart JE; Yoon KJ; Whelan K; Beierle EA
    Sci Rep; 2019 Sep; 9(1):13259. PubMed ID: 31519958
    [TBL] [Abstract][Full Text] [Related]  

  • 19. FAK Expression, Not Kinase Activity, Is a Key Mediator of Thyroid Tumorigenesis and Protumorigenic Processes.
    Kessler BE; Sharma V; Zhou Q; Jing X; Pike LA; Kerege AA; Sams SB; Schweppe RE
    Mol Cancer Res; 2016 Sep; 14(9):869-82. PubMed ID: 27259715
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Analyses of merlin/NF2 connection to FAK inhibitor responsiveness in serous ovarian cancer.
    Shah NR; Tancioni I; Ward KK; Lawson C; Chen XL; Jean C; Sulzmaier FJ; Uryu S; Miller NL; Connolly DC; Schlaepfer DD
    Gynecol Oncol; 2014 Jul; 134(1):104-11. PubMed ID: 24786638
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.