These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

292 related articles for article (PubMed ID: 25278019)

  • 1. Orexin/hypocretin activates mTOR complex 1 (mTORC1) via an Erk/Akt-independent and calcium-stimulated lysosome v-ATPase pathway.
    Wang Z; Liu S; Kakizaki M; Hirose Y; Ishikawa Y; Funato H; Yanagisawa M; Yu Y; Liu Q
    J Biol Chem; 2014 Nov; 289(46):31950-31959. PubMed ID: 25278019
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Orexin A protects cells from apoptosis by regulating FoxO1 and mTORC1 through the OX1R/PI3K/AKT signaling pathway in hepatocytes.
    Ju SJ; Zhao Y; Chang X; Guo L
    Int J Mol Med; 2014 Jul; 34(1):153-9. PubMed ID: 24807827
    [TBL] [Abstract][Full Text] [Related]  

  • 3. mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase.
    Zoncu R; Bar-Peled L; Efeyan A; Wang S; Sancak Y; Sabatini DM
    Science; 2011 Nov; 334(6056):678-83. PubMed ID: 22053050
    [TBL] [Abstract][Full Text] [Related]  

  • 4. RhoA modulates signaling through the mechanistic target of rapamycin complex 1 (mTORC1) in mammalian cells.
    Gordon BS; Kazi AA; Coleman CS; Dennis MD; Chau V; Jefferson LS; Kimball SR
    Cell Signal; 2014 Mar; 26(3):461-7. PubMed ID: 24316235
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Pharmacological inhibition of lysosomes activates the MTORC1 signaling pathway in chondrocytes in an autophagy-independent manner.
    Newton PT; Vuppalapati KK; Bouderlique T; Chagin AS
    Autophagy; 2015; 11(9):1594-607. PubMed ID: 26259639
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Effects of orexin A on glucose metabolism in human hepatocellular carcinoma in vitro via PI3K/Akt/mTOR-dependent and -independent mechanism.
    Liu Y; Zhao Y; Guo L
    Mol Cell Endocrinol; 2016 Jan; 420():208-16. PubMed ID: 26549689
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Proton-assisted amino acid transporter PAT1 complexes with Rag GTPases and activates TORC1 on late endosomal and lysosomal membranes.
    Ögmundsdóttir MH; Heublein S; Kazi S; Reynolds B; Visvalingam SM; Shaw MK; Goberdhan DC
    PLoS One; 2012; 7(5):e36616. PubMed ID: 22574197
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Ursolic acid inhibits leucine-stimulated mTORC1 signaling by suppressing mTOR localization to lysosome.
    Ou X; Liu M; Luo H; Dong LQ; Liu F
    PLoS One; 2014; 9(4):e95393. PubMed ID: 24740400
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Rag GTPase in amino acid signaling.
    Kim J; Kim E
    Amino Acids; 2016 Apr; 48(4):915-928. PubMed ID: 26781224
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Redox regulates mammalian target of rapamycin complex 1 (mTORC1) activity by modulating the TSC1/TSC2-Rheb GTPase pathway.
    Yoshida S; Hong S; Suzuki T; Nada S; Mannan AM; Wang J; Okada M; Guan KL; Inoki K
    J Biol Chem; 2011 Sep; 286(37):32651-60. PubMed ID: 21784859
    [TBL] [Abstract][Full Text] [Related]  

  • 11. ERK and Akt signaling pathways function through parallel mechanisms to promote mTORC1 signaling.
    Winter JN; Jefferson LS; Kimball SR
    Am J Physiol Cell Physiol; 2011 May; 300(5):C1172-80. PubMed ID: 21289294
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Suppression of lysosome function induces autophagy via a feedback down-regulation of MTOR complex 1 (MTORC1) activity.
    Li M; Khambu B; Zhang H; Kang JH; Chen X; Chen D; Vollmer L; Liu PQ; Vogt A; Yin XM
    J Biol Chem; 2013 Dec; 288(50):35769-80. PubMed ID: 24174532
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acids.
    Hoxhaj G; Caddye E; Najafov A; Houde VP; Johnson C; Dissanayake K; Toth R; Campbell DG; Prescott AR; MacKintosh C
    Elife; 2016 Apr; 5():. PubMed ID: 27244671
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Receptor-recognized α₂-macroglobulin binds to cell surface-associated GRP78 and activates mTORC1 and mTORC2 signaling in prostate cancer cells.
    Misra UK; Pizzo SV
    PLoS One; 2012; 7(12):e51735. PubMed ID: 23272152
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Orexin A affects HepG2 human hepatocellular carcinoma cells glucose metabolism via HIF-1α-dependent and -independent mechanism.
    Wan X; Liu Y; Zhao Y; Sun X; Fan D; Guo L
    PLoS One; 2017; 12(9):e0184213. PubMed ID: 28886081
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Signaling by FGF Receptor 2, Not FGF Receptor 1, Regulates Myelin Thickness through Activation of ERK1/2-MAPK, Which Promotes mTORC1 Activity in an Akt-Independent Manner.
    Furusho M; Ishii A; Bansal R
    J Neurosci; 2017 Mar; 37(11):2931-2946. PubMed ID: 28193689
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Dynein light chain Tctex-type 1 modulates orexin signaling through its interaction with orexin 1 receptor.
    Duguay D; Bélanger-Nelson E; Mongrain V; Beben A; Khatchadourian A; Cermakian N
    PLoS One; 2011; 6(10):e26430. PubMed ID: 22028875
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Hyperactivation of mammalian target of rapamycin complex 1 (mTORC1) promotes breast cancer progression through enhancing glucose starvation-induced autophagy and Akt signaling.
    Chen Y; Wei H; Liu F; Guan JL
    J Biol Chem; 2014 Jan; 289(2):1164-73. PubMed ID: 24275666
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Amino acids activate mammalian target of rapamycin (mTOR) complex 1 without changing Rag GTPase guanyl nucleotide charging.
    Oshiro N; Rapley J; Avruch J
    J Biol Chem; 2014 Jan; 289(5):2658-74. PubMed ID: 24337580
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Metabolism. Differential regulation of mTORC1 by leucine and glutamine.
    Jewell JL; Kim YC; Russell RC; Yu FX; Park HW; Plouffe SW; Tagliabracci VS; Guan KL
    Science; 2015 Jan; 347(6218):194-8. PubMed ID: 25567907
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.