157 related articles for article (PubMed ID: 25283137)
1. Chloral hydrate, through biotransformation to dichloroacetate, inhibits maleylacetoacetate isomerase and tyrosine catabolism in humans.
Shroads AL; Coats BS; Langaee T; Shuster JJ; Stacpoole PW
Drug Metab Pers Ther; 2015 Mar; 30(1):49-55. PubMed ID: 25283137
[TBL] [Abstract][Full Text] [Related]
2. Haplotype variations in glutathione transferase zeta 1 influence the kinetics and dynamics of chronic dichloroacetate in children.
Shroads AL; Coats BS; McDonough CW; Langaee T; Stacpoole PW
J Clin Pharmacol; 2015 Jan; 55(1):50-5. PubMed ID: 25079374
[TBL] [Abstract][Full Text] [Related]
3. Human polymorphisms in the glutathione transferase zeta 1/maleylacetoacetate isomerase gene influence the toxicokinetics of dichloroacetate.
Shroads AL; Langaee T; Coats BS; Kurtz TL; Bullock JR; Weithorn D; Gong Y; Wagner DA; Ostrov DA; Johnson JA; Stacpoole PW
J Clin Pharmacol; 2012 Jun; 52(6):837-49. PubMed ID: 21642471
[TBL] [Abstract][Full Text] [Related]
4. Inhibition and recovery of rat hepatic glutathione S-transferase zeta and alteration of tyrosine metabolism following dichloroacetate exposure and withdrawal.
Guo X; Dixit V; Liu H; Shroads AL; Henderson GN; James MO; Stacpoole PW
Drug Metab Dispos; 2006 Jan; 34(1):36-42. PubMed ID: 16199472
[TBL] [Abstract][Full Text] [Related]
5. Dichloroacetate toxicokinetics and disruption of tyrosine catabolism in B6C3F1 mice: dose-response relationships and age as a modifying factor.
Schultz IR; Merdink JL; Gonzalez-Leon A; Bull RJ
Toxicology; 2002 May; 173(3):229-47. PubMed ID: 11960676
[TBL] [Abstract][Full Text] [Related]
6. Clinical physiology and pharmacology of GSTZ1/MAAI.
Stacpoole PW
Biochem Pharmacol; 2023 Nov; 217():115818. PubMed ID: 37742772
[TBL] [Abstract][Full Text] [Related]
7. Pharmacologic or genetic ablation of maleylacetoacetate isomerase increases levels of toxic tyrosine catabolites in rodents.
Ammini CV; Fernandez-Canon J; Shroads AL; Cornett R; Cheung J; James MO; Henderson GN; Grompe M; Stacpoole PW
Biochem Pharmacol; 2003 Nov; 66(10):2029-38. PubMed ID: 14599561
[TBL] [Abstract][Full Text] [Related]
8. NTP technical report on the toxicity and metabolism studies of chloral hydrate (CAS No. 302-17-0). Administered by gavage to F344/N rats and B6C3F1 mice.
Beland FA
Toxic Rep Ser; 1999 Aug; (59):1-66, A1-E7. PubMed ID: 11803702
[TBL] [Abstract][Full Text] [Related]
9. Pharmacokinetics of oral dichloroacetate in dogs.
Maisenbacher HW; Shroads AL; Zhong G; Daigle AD; Abdelmalak MM; Samper IS; Mincey BD; James MO; Stacpoole PW
J Biochem Mol Toxicol; 2013 Dec; 27(12):522-5. PubMed ID: 24038869
[TBL] [Abstract][Full Text] [Related]
10. Perturbation of maleylacetoacetic acid metabolism in rats with dichloroacetic Acid-induced glutathione transferase zeta deficiency.
Lantum HB; Cornejo J; Pierce RH; Anders MW
Toxicol Sci; 2003 Jul; 74(1):192-202. PubMed ID: 12730618
[TBL] [Abstract][Full Text] [Related]
11. Kinetics of the biotransformation of maleylacetone and chlorofluoroacetic acid by polymorphic variants of human glutathione transferase zeta (hGSTZ1-1).
Lantum HB; Board PG; Anders MW
Chem Res Toxicol; 2002 Jul; 15(7):957-63. PubMed ID: 12119007
[TBL] [Abstract][Full Text] [Related]
12. Age-dependent kinetics and metabolism of dichloroacetate: possible relevance to toxicity.
Shroads AL; Guo X; Dixit V; Liu HP; James MO; Stacpoole PW
J Pharmacol Exp Ther; 2008 Mar; 324(3):1163-71. PubMed ID: 18096758
[TBL] [Abstract][Full Text] [Related]
13. Exposure of Rats to Multiple Oral Doses of Dichloroacetate Results in Upregulation of Hepatic Glutathione Transferases and NAD(P)H Dehydrogenase [Quinone] 1.
Squirewell EJ; Mareus R; Horne LP; Stacpoole PW; James MO
Drug Metab Dispos; 2020 Nov; 48(11):1224-1230. PubMed ID: 32873592
[TBL] [Abstract][Full Text] [Related]
14. Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors.
Dunbar EM; Coats BS; Shroads AL; Langaee T; Lew A; Forder JR; Shuster JJ; Wagner DA; Stacpoole PW
Invest New Drugs; 2014 Jun; 32(3):452-64. PubMed ID: 24297161
[TBL] [Abstract][Full Text] [Related]
15. Inhibition of glutathione S-transferase zeta and tyrosine metabolism by dichloroacetate: a potential unifying mechanism for its altered biotransformation and toxicity.
Cornett R; James MO; Henderson GN; Cheung J; Shroads AL; Stacpoole PW
Biochem Biophys Res Commun; 1999 Sep; 262(3):752-6. PubMed ID: 10471397
[TBL] [Abstract][Full Text] [Related]
16. Pharmacokinetic analysis of chloral hydrate and its metabolism in B6C3F1 mice.
Abbas RR; Seckel CS; Kidney JK; Fisher JW
Drug Metab Dispos; 1996 Dec; 24(12):1340-6. PubMed ID: 8971140
[TBL] [Abstract][Full Text] [Related]
17. Mice deficient in glutathione transferase zeta/maleylacetoacetate isomerase exhibit a range of pathological changes and elevated expression of alpha, mu, and pi class glutathione transferases.
Lim CE; Matthaei KI; Blackburn AC; Davis RP; Dahlstrom JE; Koina ME; Anders MW; Board PG
Am J Pathol; 2004 Aug; 165(2):679-93. PubMed ID: 15277241
[TBL] [Abstract][Full Text] [Related]
18. Prenatal and postnatal expression of glutathione transferase ΞΆ 1 in human liver and the roles of haplotype and subject age in determining activity with dichloroacetate.
Li W; Gu Y; James MO; Hines RN; Simpson P; Langaee T; Stacpoole PW
Drug Metab Dispos; 2012 Feb; 40(2):232-9. PubMed ID: 22028318
[TBL] [Abstract][Full Text] [Related]
19. Mitochondrion as a novel site of dichloroacetate biotransformation by glutathione transferase zeta 1.
Li W; James MO; McKenzie SC; Calcutt NA; Liu C; Stacpoole PW
J Pharmacol Exp Ther; 2011 Jan; 336(1):87-94. PubMed ID: 20884751
[TBL] [Abstract][Full Text] [Related]
20. Effect of enterohepatic circulation on the pharmacokinetics of chloral hydrate and its metabolites in F344 rats.
Merdink JL; Stenner RD; Stevens DK; Parker JC; Bull RJ
J Toxicol Environ Health A; 1999 Jul; 57(5):357-68. PubMed ID: 10405189
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]