BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

560 related articles for article (PubMed ID: 25292434)

  • 1. Targeting Hsp90/Hsp70-based protein quality control for treatment of adult onset neurodegenerative diseases.
    Pratt WB; Gestwicki JE; Osawa Y; Lieberman AP
    Annu Rev Pharmacol Toxicol; 2015; 55():353-71. PubMed ID: 25292434
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Inhibition of hsp70 by methylene blue affects signaling protein function and ubiquitination and modulates polyglutamine protein degradation.
    Wang AM; Morishima Y; Clapp KM; Peng HM; Pratt WB; Gestwicki JE; Osawa Y; Lieberman AP
    J Biol Chem; 2010 May; 285(21):15714-23. PubMed ID: 20348093
    [TBL] [Abstract][Full Text] [Related]  

  • 3. A model in which heat shock protein 90 targets protein-folding clefts: rationale for a new approach to neuroprotective treatment of protein folding diseases.
    Pratt WB; Morishima Y; Gestwicki JE; Lieberman AP; Osawa Y
    Exp Biol Med (Maywood); 2014 Nov; 239(11):1405-13. PubMed ID: 24990484
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Modulation of heme/substrate binding cleft of neuronal nitric-oxide synthase (nNOS) regulates binding of Hsp90 and Hsp70 proteins and nNOS ubiquitination.
    Peng HM; Morishima Y; Pratt WB; Osawa Y
    J Biol Chem; 2012 Jan; 287(2):1556-65. PubMed ID: 22128174
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Ca2+/S100 proteins act as upstream regulators of the chaperone-associated ubiquitin ligase CHIP (C terminus of Hsc70-interacting protein).
    Shimamoto S; Kubota Y; Yamaguchi F; Tokumitsu H; Kobayashi R
    J Biol Chem; 2013 Mar; 288(10):7158-68. PubMed ID: 23344957
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The Hsp70-Hsp90 go-between Hop/Stip1/Sti1 is a proteostatic switch and may be a drug target in cancer and neurodegeneration.
    Bhattacharya K; Picard D
    Cell Mol Life Sci; 2021 Dec; 78(23):7257-7273. PubMed ID: 34677645
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Identification of residues on Hsp70 and Hsp90 ubiquitinated by the cochaperone CHIP.
    Kundrat L; Regan L
    J Mol Biol; 2010 Jan; 395(3):587-94. PubMed ID: 19913553
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Modulation of Hsp90 function in neurodegenerative disorders: a molecular-targeted therapy against disease-causing protein.
    Waza M; Adachi H; Katsuno M; Minamiyama M; Tanaka F; Doyu M; Sobue G
    J Mol Med (Berl); 2006 Aug; 84(8):635-46. PubMed ID: 16741751
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Proposal for a role of the Hsp90/Hsp70-based chaperone machinery in making triage decisions when proteins undergo oxidative and toxic damage.
    Pratt WB; Morishima Y; Peng HM; Osawa Y
    Exp Biol Med (Maywood); 2010 Mar; 235(3):278-89. PubMed ID: 20404045
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Hsp multichaperone complex buffers pathologically modified Tau.
    Moll A; Ramirez LM; Ninov M; Schwarz J; Urlaub H; Zweckstetter M
    Nat Commun; 2022 Jun; 13(1):3668. PubMed ID: 35760815
    [TBL] [Abstract][Full Text] [Related]  

  • 11. CHIP participates in protein triage decisions by preferentially ubiquitinating Hsp70-bound substrates.
    Stankiewicz M; Nikolay R; Rybin V; Mayer MP
    FEBS J; 2010 Aug; 277(16):3353-67. PubMed ID: 20618441
    [TBL] [Abstract][Full Text] [Related]  

  • 12. HSP70-HSP90 Chaperone Networking in Protein-Misfolding Disease.
    Prodromou C; Aran-Guiu X; Oberoi J; Perna L; Chapple JP; van der Spuy J
    Subcell Biochem; 2023; 101():389-425. PubMed ID: 36520314
    [TBL] [Abstract][Full Text] [Related]  

  • 13. CHIP: A Co-chaperone for Degradation by the Proteasome and Lysosome.
    Chakraborty A; Edkins AL
    Subcell Biochem; 2023; 101():351-387. PubMed ID: 36520313
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Balance between folding and degradation for Hsp90-dependent client proteins: a key role for CHIP.
    Kundrat L; Regan L
    Biochemistry; 2010 Sep; 49(35):7428-38. PubMed ID: 20704274
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The ubiquitin ligase CHIP regulates c-Myc stability and transcriptional activity.
    Paul I; Ahmed SF; Bhowmik A; Deb S; Ghosh MK
    Oncogene; 2013 Mar; 32(10):1284-95. PubMed ID: 22543587
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Molecular mechanism of 17-allylamino-17-demethoxygeldanamycin (17-AAG)-induced AXL receptor tyrosine kinase degradation.
    Krishnamoorthy GP; Guida T; Alfano L; Avilla E; Santoro M; Carlomagno F; Melillo RM
    J Biol Chem; 2013 Jun; 288(24):17481-94. PubMed ID: 23629654
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Hsp70 and Hsp90 oppositely regulate TGF-β signaling through CHIP/Stub1.
    Shang Y; Xu X; Duan X; Guo J; Wang Y; Ren F; He D; Chang Z
    Biochem Biophys Res Commun; 2014 Mar; 446(1):387-92. PubMed ID: 24613385
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Hsp70 and Hsp90 multichaperone complexes sequentially regulate thiazide-sensitive cotransporter endoplasmic reticulum-associated degradation and biogenesis.
    Donnelly BF; Needham PG; Snyder AC; Roy A; Khadem S; Brodsky JL; Subramanya AR
    J Biol Chem; 2013 May; 288(18):13124-35. PubMed ID: 23482560
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Recruitment of a cytoplasmic chaperone relay by the A2A adenosine receptor.
    Bergmayr C; Thurner P; Keuerleber S; Kudlacek O; Nanoff C; Freissmuth M; Gruber CW
    J Biol Chem; 2013 Oct; 288(40):28831-44. PubMed ID: 23965991
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Dynamic cycling with Hsp90 stabilizes neuronal nitric oxide synthase through calmodulin-dependent inhibition of ubiquitination.
    Peng HM; Morishima Y; Clapp KM; Lau M; Pratt WB; Osawa Y
    Biochemistry; 2009 Sep; 48(35):8483-90. PubMed ID: 19642705
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 28.