296 related articles for article (PubMed ID: 2529254)
1. Folate-pool interconversions and inhibition of biosynthetic processes after exposure of L1210 leukemia cells to antifolates. Experimental and network thermodynamic analyses of the role of dihydrofolate polyglutamylates in antifolate action in cells.
Seither RL; Trent DF; Mikulecky DC; Rape TJ; Goldman ID
J Biol Chem; 1989 Oct; 264(29):17016-23. PubMed ID: 2529254
[TBL] [Abstract][Full Text] [Related]
2. Effect of direct suppression of thymidylate synthase at the 5,10-methylenetetrahydrofolate binding site on the interconversion of tetrahydrofolate cofactors to dihydrofolate by antifolates. Influence of degree of dihydrofolate reductase inhibition.
Seither RL; Trent DF; Mikulecky DC; Rape TJ; Goldman ID
J Biol Chem; 1991 Mar; 266(7):4112-8. PubMed ID: 1825652
[TBL] [Abstract][Full Text] [Related]
3. Interconversion of tetrahydrofolate cofactors to dihydrofolate induced by trimetrexate after suppression of thymidylate synthase by fluorodeoxyuridine in L1210 leukemia cells.
Seither RL; Rape TJ; Goldman ID
Biochem Pharmacol; 1992 Jun; 43(12):2647-54. PubMed ID: 1385949
[TBL] [Abstract][Full Text] [Related]
4. Rate and extent of interconversion of tetrahydrofolate cofactors to dihydrofolate after cessation of dihydrofolate reductase activity in stationary versus log phase L1210 leukemia cells.
Trent DF; Seither RL; Goldman ID
J Biol Chem; 1991 Mar; 266(9):5445-9. PubMed ID: 1825999
[TBL] [Abstract][Full Text] [Related]
5. Compartmentation of intracellular folates. Failure to interconvert tetrahydrofolate cofactors to dihydrofolate in mitochondria of L1210 leukemia cells treated with trimetrexate.
Trent DF; Seither RL; Goldman ID
Biochem Pharmacol; 1991 Aug; 42(5):1015-9. PubMed ID: 1831361
[TBL] [Abstract][Full Text] [Related]
6. Evidence for a localized conversion of endogenous tetrahydrofolate cofactors to dihydrofolate as an important element in antifolate action in murine leukemia cells.
Matherly LH; Muench SP
Biochem Pharmacol; 1990 Jun; 39(12):2005-14. PubMed ID: 2141258
[TBL] [Abstract][Full Text] [Related]
7. Further studies on the pharmacologic effects of the 7-hydroxy catabolite of methotrexate in the L1210 murine leukemia cell.
Seither RL; Rape TJ; Goldman ID
Biochem Pharmacol; 1989 Mar; 38(5):815-22. PubMed ID: 2467676
[TBL] [Abstract][Full Text] [Related]
8. Antifolate polyglutamylation and competitive drug displacement at dihydrofolate reductase as important elements in leucovorin rescue in L1210 cells.
Matherly LH; Barlowe CK; Goldman ID
Cancer Res; 1986 Feb; 46(2):588-93. PubMed ID: 2416428
[TBL] [Abstract][Full Text] [Related]
9. Biochemical pharmacology of the lipophilic antifolate, trimetrexate.
Jackson RC; Fry DW; Boritzki TJ; Besserer JA; Leopold WR; Sloan BJ; Elslager EF
Adv Enzyme Regul; 1984; 22():187-206. PubMed ID: 6236675
[TBL] [Abstract][Full Text] [Related]
10. The effects on 4-aminoantifolates on 5-formyltetrahydrofolate metabolism in L1210 cells. A biochemical basis of the selectivity of leucovorin rescue.
Matherly LH; Barlowe CK; Phillips VM; Goldman ID
J Biol Chem; 1987 Jan; 262(2):710-7. PubMed ID: 2948949
[TBL] [Abstract][Full Text] [Related]
11. The role of cellular folates in the enhancement of activity of the thymidylate synthase inhibitor 10-propargyl-5,8-dideazafolate against hepatoma cells in vitro by inhibitors of dihydrofolate reductase.
Galivan J; Rhee MS; Johnson TB; Dilwith R; Nair MG; Bunni M; Priest DG
J Biol Chem; 1989 Jun; 264(18):10685-92. PubMed ID: 2525127
[TBL] [Abstract][Full Text] [Related]
12. Increased thymidylate synthase in L1210 cells possessing acquired resistance to N10-propargyl-5,8-dideazafolic acid (CB3717): development, characterization, and cross-resistance studies.
Jackman AL; Alison DL; Calvert AH; Harrap KR
Cancer Res; 1986 Jun; 46(6):2810-5. PubMed ID: 2938731
[TBL] [Abstract][Full Text] [Related]
13. Predictions of a network thermodynamics computer model relating to the mechanism of methotrexate rescue by 5-formyltetrahydrofolate and to the importance of inhibition of thymidylate synthase by methotrexate-polyglutamates.
White JC
Adv Exp Med Biol; 1983; 163():305-26. PubMed ID: 6193692
[TBL] [Abstract][Full Text] [Related]
14. Computer modelling of antifolate inhibition of folate metabolism using hybrid functional petri nets.
Assaraf YG; Ifergan I; Kadry WN; Pinter RY
J Theor Biol; 2006 Jun; 240(4):637-47. PubMed ID: 16352313
[TBL] [Abstract][Full Text] [Related]
15. Role for cytosolic folate-binding proteins in the compartmentation of endogenous tetrahydrofolates and the 5-formyl tetrahydrofolate-mediated enhancement of 5-fluoro-2'-deoxyuridine antitumor activity in vitro.
Matherly LH; Czajkowski CA; Muench SP; Psiakis JT
Cancer Res; 1990 Jun; 50(11):3262-9. PubMed ID: 2139802
[TBL] [Abstract][Full Text] [Related]
16. Biochemical and biological studies on 2-desamino-2-methylaminopterin, an antifolate the polyglutamates of which are more potent than the monoglutamate against three key enzymes of folate metabolism.
Rosowsky A; Galivan J; Beardsley GP; Bader H; O'Connor BM; Russello O; Moroson BA; DeYarman MT; Kerwar SS; Freisheim JH
Cancer Res; 1992 Apr; 52(8):2148-55. PubMed ID: 1313737
[TBL] [Abstract][Full Text] [Related]
17. Role of methylenetetrahydrofolate depletion in methotrexate-mediated intracellular thymidylate synthesis inhibition in cultured L1210 cells.
Bunni M; Doig MT; Donato H; Kesavan V; Priest DG
Cancer Res; 1988 Jun; 48(12):3398-404. PubMed ID: 3370638
[TBL] [Abstract][Full Text] [Related]
18. Membrane transport of natural folates and antifolate compounds in murine L1210 leukemia cells: role of carrier- and receptor-mediated transport systems.
Westerhof GR; Jansen G; van Emmerik N; Kathmann I; Rijksen G; Jackman AL; Schornagel JH
Cancer Res; 1991 Oct; 51(20):5507-13. PubMed ID: 1655252
[TBL] [Abstract][Full Text] [Related]
19. Regulation of carrier-mediated transport of folates and antifolates in methotrexate-sensitive and-resistant leukemia cells.
Jansen G; Mauritz RM; Assaraf YG; Sprecher H; Drori S; Kathmann I; Westerhof GR; Priest DG; Bunni M; Pinedo HM; Schornagel JH; Peters GJ
Adv Enzyme Regul; 1997; 37():59-76. PubMed ID: 9381986
[TBL] [Abstract][Full Text] [Related]
20. Depletion of 5,10-methylenetetrahydrofolate and 10-formyltetrahydrofolate by methotrexate in cultured hepatoma cells.
Rhee MS; Coward JK; Galivan J
Mol Pharmacol; 1992 Nov; 42(5):909-16. PubMed ID: 1435754
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
