188 related articles for article (PubMed ID: 25297465)
1. The p38alpha mitogen-activated protein kinase limits the CNS proinflammatory cytokine response to systemic lipopolysaccharide, potentially through an IL-10 dependent mechanism.
Bachstetter AD; Xing B; Van Eldik LJ
J Neuroinflammation; 2014 Oct; 11():175. PubMed ID: 25297465
[TBL] [Abstract][Full Text] [Related]
2. Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ).
Bachstetter AD; Xing B; de Almeida L; Dimayuga ER; Watterson DM; Van Eldik LJ
J Neuroinflammation; 2011 Jul; 8():79. PubMed ID: 21733175
[TBL] [Abstract][Full Text] [Related]
3. The p38α MAPK regulates microglial responsiveness to diffuse traumatic brain injury.
Bachstetter AD; Rowe RK; Kaneko M; Goulding D; Lifshitz J; Van Eldik LJ
J Neurosci; 2013 Apr; 33(14):6143-53. PubMed ID: 23554495
[TBL] [Abstract][Full Text] [Related]
4. Microglial p38α MAPK is critical for LPS-induced neuron degeneration, through a mechanism involving TNFα.
Xing B; Bachstetter AD; Van Eldik LJ
Mol Neurodegener; 2011 Dec; 6():84. PubMed ID: 22185458
[TBL] [Abstract][Full Text] [Related]
5. Deficiency in p38β MAPK fails to inhibit cytokine production or protect neurons against inflammatory insult in in vitro and in vivo mouse models.
Xing B; Bachstetter AD; Van Eldik LJ
PLoS One; 2013; 8(2):e56852. PubMed ID: 23457629
[TBL] [Abstract][Full Text] [Related]
6. Down-regulation of p38 mitogen-activated protein kinase activation and proinflammatory cytokine production by mitogen-activated protein kinase inhibitors in inflammatory bowel disease.
Docena G; Rovedatti L; Kruidenier L; Fanning A; Leakey NA; Knowles CH; Lee K; Shanahan F; Nally K; McLean PG; Di Sabatino A; MacDonald TT
Clin Exp Immunol; 2010 Oct; 162(1):108-15. PubMed ID: 20731675
[TBL] [Abstract][Full Text] [Related]
7. Target engagement analysis and link to pharmacodynamic endpoint for a novel class of CNS-penetrant and efficacious p38α MAPK inhibitors.
Bachstetter AD; Watterson DM; Van Eldik LJ
J Neuroimmune Pharmacol; 2014 Sep; 9(4):454-60. PubMed ID: 24789302
[TBL] [Abstract][Full Text] [Related]
8. Macrophage p38α promotes nutritional steatohepatitis through M1 polarization.
Zhang X; Fan L; Wu J; Xu H; Leung WY; Fu K; Wu J; Liu K; Man K; Yang X; Han J; Ren J; Yu J
J Hepatol; 2019 Jul; 71(1):163-174. PubMed ID: 30914267
[TBL] [Abstract][Full Text] [Related]
9. Macrophage deletion of p38alpha partially impairs lipopolysaccharide-induced cellular activation.
Kang YJ; Chen J; Otsuka M; Mols J; Ren S; Wang Y; Han J
J Immunol; 2008 Apr; 180(7):5075-82. PubMed ID: 18354233
[TBL] [Abstract][Full Text] [Related]
10. Deletion of p38α MAPK in microglia blunts trauma-induced inflammatory responses in mice.
Morganti JM; Goulding DS; Van Eldik LJ
J Neuroinflammation; 2019 May; 16(1):98. PubMed ID: 31077217
[TBL] [Abstract][Full Text] [Related]
11. p38α senses environmental stress to control innate immune responses via mechanistic target of rapamycin.
Katholnig K; Kaltenecker CC; Hayakawa H; Rosner M; Lassnig C; Zlabinger GJ; Gaestel M; Müller M; Hengstschläger M; Hörl WH; Park JM; Säemann MD; Weichhart T
J Immunol; 2013 Feb; 190(4):1519-27. PubMed ID: 23315073
[TBL] [Abstract][Full Text] [Related]
12. Expression of a constitutively active p38α mutant in mice causes early death, anemia, and accumulation of immunosuppressive cells.
Darlyuk-Saadon I; Heng CKM; Bai C; Gilad N; Yu WP; Meng Huang Mok M; Wong WSF; Engelberg D
FEBS J; 2021 Jul; 288(13):3978-3999. PubMed ID: 33410203
[TBL] [Abstract][Full Text] [Related]
13. Defining the involvement of p38alpha MAPK in the production of anti- and proinflammatory cytokines using an SB 203580-resistant form of the kinase.
Guo X; Gerl RE; Schrader JW
J Biol Chem; 2003 Jun; 278(25):22237-42. PubMed ID: 12637577
[TBL] [Abstract][Full Text] [Related]
14. The p38alpha mitogen-activated protein kinase as a central nervous system drug discovery target.
Borders AS; de Almeida L; Van Eldik LJ; Watterson DM
BMC Neurosci; 2008 Dec; 9 Suppl 2(Suppl 2):S12. PubMed ID: 19090985
[TBL] [Abstract][Full Text] [Related]
15. Molecular mechanism of lipopolysaccharide-induced SOCS-3 gene expression in macrophages and microglia.
Qin H; Roberts KL; Niyongere SA; Cong Y; Elson CO; Benveniste EN
J Immunol; 2007 Nov; 179(9):5966-76. PubMed ID: 17947670
[TBL] [Abstract][Full Text] [Related]
16. Morphine mediates a proinflammatory phenotype via μ-opioid receptor-PKCɛ-Akt-ERK1/2 signaling pathway in activated microglial cells.
Merighi S; Gessi S; Varani K; Fazzi D; Stefanelli A; Borea PA
Biochem Pharmacol; 2013 Aug; 86(4):487-96. PubMed ID: 23796752
[TBL] [Abstract][Full Text] [Related]
17. p38α (MAPK14) critically regulates the immunological response and the production of specific cytokines and chemokines in astrocytes.
Lo U; Selvaraj V; Plane JM; Chechneva OV; Otsu K; Deng W
Sci Rep; 2014 Dec; 4():7405. PubMed ID: 25502009
[TBL] [Abstract][Full Text] [Related]
18. Anti-inflammatory roles of p38α MAPK in macrophages are context dependent and require IL-10.
Raza A; Crothers JW; McGill MM; Mawe GM; Teuscher C; Krementsov DN
J Leukoc Biol; 2017 Nov; 102(5):1219-1227. PubMed ID: 28877953
[TBL] [Abstract][Full Text] [Related]
19. Triggering Receptor Expressed on Myeloid Cells 2 Overexpression Inhibits Proinflammatory Cytokines in Lipopolysaccharide-Stimulated Microglia.
Zhang X; Yan F; Cui J; Wu Y; Luan H; Yin M; Zhao Z; Feng J; Zhang J
Mediators Inflamm; 2017; 2017():9340610. PubMed ID: 29180839
[TBL] [Abstract][Full Text] [Related]
20. The p38α mitogen-activated protein kinase is a key regulator of myelination and remyelination in the CNS.
Chung SH; Biswas S; Selvaraj V; Liu XB; Sohn J; Jiang P; Chen C; Chmilewsky F; Marzban H; Horiuchi M; Pleasure DE; Deng W
Cell Death Dis; 2015 May; 6(5):e1748. PubMed ID: 25950478
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
