BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

211 related articles for article (PubMed ID: 25310082)

  • 1. Bypassing fluoroquinolone resistance with quinazolinediones: studies of drug-gyrase-DNA complexes having implications for drug design.
    Drlica K; Mustaev A; Towle TR; Luan G; Kerns RJ; Berger JM
    ACS Chem Biol; 2014 Dec; 9(12):2895-904. PubMed ID: 25310082
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Fluoroquinolone-gyrase-DNA complexes: two modes of drug binding.
    Mustaev A; Malik M; Zhao X; Kurepina N; Luan G; Oppegard LM; Hiasa H; Marks KR; Kerns RJ; Berger JM; Drlica K
    J Biol Chem; 2014 May; 289(18):12300-12. PubMed ID: 24497635
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Overcoming target-mediated quinolone resistance in topoisomerase IV by introducing metal-ion-independent drug-enzyme interactions.
    Aldred KJ; Schwanz HA; Li G; McPherson SA; Turnbough CL; Kerns RJ; Osheroff N
    ACS Chem Biol; 2013 Dec; 8(12):2660-8. PubMed ID: 24047414
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Functional Characterization of the DNA Gyrases in Fluoroquinolone-Resistant Mutants of Francisella novicida.
    Caspar Y; Siebert C; Sutera V; Villers C; Aubry A; Mayer C; Maurin M; Renesto P
    Antimicrob Agents Chemother; 2017 Apr; 61(4):. PubMed ID: 28167561
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Cleavable-complex formation by wild-type and quinolone-resistant Streptococcus pneumoniae type II topoisomerases mediated by gemifloxacin and other fluoroquinolones.
    Yague G; Morris JE; Pan XS; Gould KA; Fisher LM
    Antimicrob Agents Chemother; 2002 Feb; 46(2):413-9. PubMed ID: 11796351
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Quinolone resistance mutations in Streptococcus pneumoniae GyrA and ParC proteins: mechanistic insights into quinolone action from enzymatic analysis, intracellular levels, and phenotypes of wild-type and mutant proteins.
    Pan XS; Yague G; Fisher LM
    Antimicrob Agents Chemother; 2001 Nov; 45(11):3140-7. PubMed ID: 11600369
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Impact of mutations in DNA gyrase genes on quinolone resistance in Campylobacter jejuni.
    Changkwanyeun R; Yamaguchi T; Kongsoi S; Changkaew K; Yokoyama K; Kim H; Suthienkul O; Usui M; Tamura Y; Nakajima C; Suzuki Y
    Drug Test Anal; 2016 Oct; 8(10):1071-1076. PubMed ID: 26857529
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Probing the differential interactions of quinazolinedione PD 0305970 and quinolones with gyrase and topoisomerase IV.
    Pan XS; Gould KA; Fisher LM
    Antimicrob Agents Chemother; 2009 Sep; 53(9):3822-31. PubMed ID: 19564360
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Bacillus anthracis GrlAV96A topoisomerase IV, a quinolone resistance mutation that does not affect the water-metal ion bridge.
    Aldred KJ; Breland EJ; McPherson SA; Turnbough CL; Kerns RJ; Osheroff N
    Antimicrob Agents Chemother; 2014 Dec; 58(12):7182-7. PubMed ID: 25246407
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The C7-aminomethylpyrrolidine group rescues the activity of a thio-fluoroquinolone.
    Lentz SRC; Chheda PR; Oppegard LM; Towle TR; Kerns RJ; Hiasa H
    Biochimie; 2019 May; 160():24-27. PubMed ID: 30763638
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Molecular determinants of the bacterial resistance to fluoroquinolones: a computational study.
    Lupala CS; Gomez-Gutierrez P; Perez JJ
    Curr Comput Aided Drug Des; 2013 Jun; 9(2):281-8. PubMed ID: 23106777
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Suppression of gyrase-mediated resistance by C7 aryl fluoroquinolones.
    Malik M; Mustaev A; Schwanz HA; Luan G; Shah N; Oppegard LM; de Souza EC; Hiasa H; Zhao X; Kerns RJ; Drlica K
    Nucleic Acids Res; 2016 Apr; 44(7):3304-16. PubMed ID: 26984528
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Use of gyrase resistance mutants to guide selection of 8-methoxy-quinazoline-2,4-diones.
    German N; Malik M; Rosen JD; Drlica K; Kerns RJ
    Antimicrob Agents Chemother; 2008 Nov; 52(11):3915-21. PubMed ID: 18765690
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Contribution of Type II Topoisomerase Mutations to Fluoroquinolone Resistance in Enterococcus faecium from Japanese Clinical Setting.
    Urushibara N; Suzaki K; Kawaguchiya M; Aung MS; Shinagawa M; Takahashi S; Kobayashi N
    Microb Drug Resist; 2018; 24(1):1-7. PubMed ID: 28504916
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Hot-spot consensus of fluoroquinolone-mediated DNA cleavage by Gram-negative and Gram-positive type II DNA topoisomerases.
    Richter SN; Giaretta G; Comuzzi V; Leo E; Mitchenall LA; Fisher LM; Maxwell A; Palumbo M
    Nucleic Acids Res; 2007; 35(18):6075-85. PubMed ID: 17766248
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Fluoroquinolone-Gyrase-DNA Cleaved Complexes.
    Luan G; Drlica K
    Methods Mol Biol; 2018; 1703():269-281. PubMed ID: 29177748
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Mutations in the gyrB, parC, and parE genes of quinolone-resistant isolates and mutants of Edwardsiella tarda.
    Kim MS; Jun LJ; Shin SB; Park MA; Jung SH; Kim K; Moon KH; Jeong HD
    J Microbiol Biotechnol; 2010 Dec; 20(12):1735-43. PubMed ID: 21193831
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Drug interactions with Bacillus anthracis topoisomerase IV: biochemical basis for quinolone action and resistance.
    Aldred KJ; McPherson SA; Wang P; Kerns RJ; Graves DE; Turnbough CL; Osheroff N
    Biochemistry; 2012 Jan; 51(1):370-81. PubMed ID: 22126453
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Mechanism of binding of fluoroquinolones to the quinolone resistance-determining region of DNA gyrase: towards an understanding of the molecular basis of quinolone resistance.
    Madurga S; Sánchez-Céspedes J; Belda I; Vila J; Giralt E
    Chembiochem; 2008 Sep; 9(13):2081-6. PubMed ID: 18677735
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Fluoroquinolone and quinazolinedione activities against wild-type and gyrase mutant strains of Mycobacterium smegmatis.
    Malik M; Marks KR; Mustaev A; Zhao X; Chavda K; Kerns RJ; Drlica K
    Antimicrob Agents Chemother; 2011 May; 55(5):2335-43. PubMed ID: 21383100
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.