These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
3. Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4. Shibata S; Zhang J; Puthumana J; Stone KL; Lifton RP Proc Natl Acad Sci U S A; 2013 May; 110(19):7838-43. PubMed ID: 23576762 [TBL] [Abstract][Full Text] [Related]
4. Calcineurin dephosphorylates Kelch-like 3, reversing phosphorylation by angiotensin II and regulating renal electrolyte handling. Ishizawa K; Wang Q; Li J; Yamazaki O; Tamura Y; Fujigaki Y; Uchida S; Lifton RP; Shibata S Proc Natl Acad Sci U S A; 2019 Feb; 116(8):3155-3160. PubMed ID: 30718414 [TBL] [Abstract][Full Text] [Related]
5. The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction. Ohta A; Schumacher FR; Mehellou Y; Johnson C; Knebel A; Macartney TJ; Wood NT; Alessi DR; Kurz T Biochem J; 2013 Apr; 451(1):111-22. PubMed ID: 23387299 [TBL] [Abstract][Full Text] [Related]
6. Role of KLHL3 and dietary K Ostrosky-Frid M; Chávez-Canales M; Zhang J; Andrukhova O; Argaiz ER; Lerdo-de-Tejada F; Murillo-de-Ozores A; Sanchez-Navarro A; Rojas-Vega L; Bobadilla NA; Vazquez N; Castañeda-Bueno M; Alessi DR; Gamba G Am J Physiol Renal Physiol; 2021 May; 320(5):F734-F747. PubMed ID: 33682442 [TBL] [Abstract][Full Text] [Related]
7. Impaired degradation of WNK1 and WNK4 kinases causes PHAII in mutant KLHL3 knock-in mice. Susa K; Sohara E; Rai T; Zeniya M; Mori Y; Mori T; Chiga M; Nomura N; Nishida H; Takahashi D; Isobe K; Inoue Y; Takeishi K; Takeda N; Sasaki S; Uchida S Hum Mol Genet; 2014 Oct; 23(19):5052-60. PubMed ID: 24821705 [TBL] [Abstract][Full Text] [Related]
8. Disease-causing mutations in KLHL3 impair its effect on WNK4 degradation. Wu G; Peng JB FEBS Lett; 2013 Jun; 587(12):1717-22. PubMed ID: 23665031 [TBL] [Abstract][Full Text] [Related]
9. Inhibition of Sodium Glucose Cotransporter 2 Attenuates the Dysregulation of Kelch-Like 3 and NaCl Cotransporter in Obese Diabetic Mice. Ishizawa K; Wang Q; Li J; Xu N; Nemoto Y; Morimoto C; Fujii W; Tamura Y; Fujigaki Y; Tsukamoto K; Fujita T; Uchida S; Shibata S J Am Soc Nephrol; 2019 May; 30(5):782-794. PubMed ID: 30914436 [TBL] [Abstract][Full Text] [Related]
10. Combined Kelch-like 3 and Cullin 3 Degradation is a Central Mechanism in Familial Hyperkalemic Hypertension in Mice. Maeoka Y; Ferdaus MZ; Cornelius RJ; Sharma A; Su XT; Miller LN; Robertson JA; Gurley SB; Yang CL; Ellison DH; McCormick JA J Am Soc Nephrol; 2022 Mar; 33(3):584-600. PubMed ID: 35064051 [TBL] [Abstract][Full Text] [Related]
11. Kelch-like 3/Cullin 3 ubiquitin ligase complex and WNK signaling in salt-sensitive hypertension and electrolyte disorder. Sohara E; Uchida S Nephrol Dial Transplant; 2016 Sep; 31(9):1417-24. PubMed ID: 26152401 [TBL] [Abstract][Full Text] [Related]
12. Impaired degradation of WNK by Akt and PKA phosphorylation of KLHL3. Yoshizaki Y; Mori Y; Tsuzaki Y; Mori T; Nomura N; Wakabayashi M; Takahashi D; Zeniya M; Kikuchi E; Araki Y; Ando F; Isobe K; Nishida H; Ohta A; Susa K; Inoue Y; Chiga M; Rai T; Sasaki S; Uchida S; Sohara E Biochem Biophys Res Commun; 2015 Nov; 467(2):229-34. PubMed ID: 26435498 [TBL] [Abstract][Full Text] [Related]
13. Decreased KLHL3 expression is involved in the activation of WNK-OSR1/SPAK-NCC cascade in type 1 diabetic mice. Guo Q; Zhang Y; Jiang GR; Zhang C Pflugers Arch; 2021 Feb; 473(2):185-196. PubMed ID: 33432425 [TBL] [Abstract][Full Text] [Related]
14. Identification of a novel KLHL3-interacting motif in the C-terminal region of WNK4. Wang L; Wu G; Peng JB Biochem Biophys Res Commun; 2023 Aug; 670():87-93. PubMed ID: 37285722 [TBL] [Abstract][Full Text] [Related]
15. Phosphorylation of KLHL3 at serine 433 impairs its interaction with the acidic motif of WNK4: a molecular dynamics study. Wang L; Peng JB Protein Sci; 2017 Feb; 26(2):163-173. PubMed ID: 27727489 [TBL] [Abstract][Full Text] [Related]
16. WNK4 is indispensable for the pathogenesis of pseudohypoaldosteronism type II caused by mutant KLHL3. Susa K; Sohara E; Takahashi D; Okado T; Rai T; Uchida S Biochem Biophys Res Commun; 2017 Sep; 491(3):727-732. PubMed ID: 28743496 [TBL] [Abstract][Full Text] [Related]
17. Generation and analysis of a mouse model of pseudohypoaldosteronism type II caused by KLHL3 mutation in BTB domain. Lin CM; Cheng CJ; Yang SS; Tseng MH; Yen MT; Sung CC; Lin SH FASEB J; 2019 Jan; 33(1):1051-1061. PubMed ID: 30148674 [TBL] [Abstract][Full Text] [Related]
18. Dual gain and loss of cullin 3 function mediates familial hyperkalemic hypertension. Cornelius RJ; Zhang C; Erspamer KJ; Agbor LN; Sigmund CD; Singer JD; Yang CL; Ellison DH Am J Physiol Renal Physiol; 2018 Oct; 315(4):F1006-F1018. PubMed ID: 29897280 [TBL] [Abstract][Full Text] [Related]
19. Structural and biochemical characterization of the KLHL3-WNK kinase interaction important in blood pressure regulation. Schumacher FR; Sorrell FJ; Alessi DR; Bullock AN; Kurz T Biochem J; 2014 Jun; 460(2):237-46. PubMed ID: 24641320 [TBL] [Abstract][Full Text] [Related]
20. Phosphorylation by PKC and PKA regulate the kinase activity and downstream signaling of WNK4. Castañeda-Bueno M; Arroyo JP; Zhang J; Puthumana J; Yarborough O; Shibata S; Rojas-Vega L; Gamba G; Rinehart J; Lifton RP Proc Natl Acad Sci U S A; 2017 Jan; 114(5):E879-E886. PubMed ID: 28096417 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]