These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
2. The role of HCA2 (GPR109A) in regulating macrophage function. Zandi-Nejad K; Takakura A; Jurewicz M; Chandraker AK; Offermanns S; Mount D; Abdi R FASEB J; 2013 Nov; 27(11):4366-74. PubMed ID: 23882124 [TBL] [Abstract][Full Text] [Related]
3. Hydroxycarboxylic Acid Receptor Ligands Modulate Proinflammatory Cytokine Expression in Human Macrophages and Adipocytes without Affecting Adipose Differentiation. Mandrika I; Tilgase A; Petrovska R; Klovins J Biol Pharm Bull; 2018; 41(10):1574-1580. PubMed ID: 30270326 [TBL] [Abstract][Full Text] [Related]
4. Activated niacin receptor HCA2 inhibits chemoattractant-mediated macrophage migration via Gβγ/PKC/ERK1/2 pathway and heterologous receptor desensitization. Shi Y; Lai X; Ye L; Chen K; Cao Z; Gong W; Jin L; Wang C; Liu M; Liao Y; Wang JM; Zhou N Sci Rep; 2017 Feb; 7():42279. PubMed ID: 28186140 [TBL] [Abstract][Full Text] [Related]
5. Effects of high fat diet on GPR109A and GPR81 gene expression. Wanders D; Graff EC; Judd RL Biochem Biophys Res Commun; 2012 Aug; 425(2):278-83. PubMed ID: 22842580 [TBL] [Abstract][Full Text] [Related]
6. Differential tissue and ligand-dependent signaling of GPR109A receptor: implications for anti-atherosclerotic therapeutic potential. Gaidarov I; Chen X; Anthony T; Maciejewski-Lenoir D; Liaw C; Unett DJ Cell Signal; 2013 Oct; 25(10):2003-16. PubMed ID: 23770183 [TBL] [Abstract][Full Text] [Related]
7. Niacin protects against abdominal aortic aneurysm formation via GPR109A independent mechanisms: role of NAD+/nicotinamide. Horimatsu T; Blomkalns AL; Ogbi M; Moses M; Kim D; Patel S; Gilreath N; Reid L; Benson TW; Pye J; Ahmadieh S; Thompson A; Robbins N; Mann A; Edgell A; Benjamin S; Stansfield BK; Huo Y; Fulton DJ; Agarwal G; Singh N; Offermanns S; Weintraub NL; Kim HW Cardiovasc Res; 2020 Dec; 116(14):2226-2238. PubMed ID: 31710686 [TBL] [Abstract][Full Text] [Related]
8. The Effect of Metformin on the Expression of GPR109A, NF-κB and IL-1β in Peripheral Blood Leukocytes from Patients with Type 2 Diabetes Mellitus. Xu X; Lin S; Chen Y; Li X; Ma S; Fu Y; Wei C; Wang C; Xu W Ann Clin Lab Sci; 2017 Sep; 47(5):556-562. PubMed ID: 29066482 [TBL] [Abstract][Full Text] [Related]
9. Nicotinic acid inhibits progression of atherosclerosis in mice through its receptor GPR109A expressed by immune cells. Lukasova M; Malaval C; Gille A; Kero J; Offermanns S J Clin Invest; 2011 Mar; 121(3):1163-73. PubMed ID: 21317532 [TBL] [Abstract][Full Text] [Related]
10. Niacin stimulates adiponectin secretion through the GPR109A receptor. Plaisance EP; Lukasova M; Offermanns S; Zhang Y; Cao G; Judd RL Am J Physiol Endocrinol Metab; 2009 Mar; 296(3):E549-58. PubMed ID: 19141678 [TBL] [Abstract][Full Text] [Related]
11. Niacin-induced hyperglycemia is partially mediated via niacin receptor GPR109a in pancreatic islets. Chen L; So WY; Li SY; Cheng Q; Boucher BJ; Leung PS Mol Cell Endocrinol; 2015 Mar; 404():56-66. PubMed ID: 25622782 [TBL] [Abstract][Full Text] [Related]
12. The β-hydroxybutyrate receptor HCA2 activates a neuroprotective subset of macrophages. Rahman M; Muhammad S; Khan MA; Chen H; Ridder DA; Müller-Fielitz H; Pokorná B; Vollbrandt T; Stölting I; Nadrowitz R; Okun JG; Offermanns S; Schwaninger M Nat Commun; 2014 May; 5():3944. PubMed ID: 24845831 [TBL] [Abstract][Full Text] [Related]
13. Sodium Butyrate Inhibits Inflammation and Maintains Epithelium Barrier Integrity in a TNBS-induced Inflammatory Bowel Disease Mice Model. Chen G; Ran X; Li B; Li Y; He D; Huang B; Fu S; Liu J; Wang W EBioMedicine; 2018 Apr; 30():317-325. PubMed ID: 29627390 [TBL] [Abstract][Full Text] [Related]
14. Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis. Singh N; Gurav A; Sivaprakasam S; Brady E; Padia R; Shi H; Thangaraju M; Prasad PD; Manicassamy S; Munn DH; Lee JR; Offermanns S; Ganapathy V Immunity; 2014 Jan; 40(1):128-39. PubMed ID: 24412617 [TBL] [Abstract][Full Text] [Related]
15. Anti-inflammatory effects of nicotinic acid in human monocytes are mediated by GPR109A dependent mechanisms. Digby JE; Martinez F; Jefferson A; Ruparelia N; Chai J; Wamil M; Greaves DR; Choudhury RP Arterioscler Thromb Vasc Biol; 2012 Mar; 32(3):669-76. PubMed ID: 22267479 [TBL] [Abstract][Full Text] [Related]
16. Dimethyl fumarate downregulates the immune response through the HCA von Glehn F; Dias-Carneiro RPC; Moraes AS; Farias AS; Silva VAPG; Oliveira FTM; Silva CEBG; de Carvalho F; Rahal E; Baecher-Allan C; Santos LMB Mult Scler Relat Disord; 2018 Jul; 23():46-50. PubMed ID: 29763776 [TBL] [Abstract][Full Text] [Related]
17. Characterization of the hydroxycarboxylic acid receptor 2 in cats. Graff EC; Norris OC; Sandey M; Kemppainen RJ; Judd RL Domest Anim Endocrinol; 2015 Oct; 53():88-94. PubMed ID: 26164006 [TBL] [Abstract][Full Text] [Related]
18. Activation of HCA2 regulates microglial responses to alleviate neurodegeneration in LPS-induced in vivo and in vitro models. He D; Fu S; Ye B; Wang H; He Y; Li Z; Li J; Gao X; Liu D J Neuroinflammation; 2023 Mar; 20(1):86. PubMed ID: 36991440 [TBL] [Abstract][Full Text] [Related]
19. Niacin Ameliorates Neuro-Inflammation in Parkinson's Disease via GPR109A. Giri B; Belanger K; Seamon M; Bradley E; Purohit S; Chong R; Morgan JC; Baban B; Wakade C Int J Mol Sci; 2019 Sep; 20(18):. PubMed ID: 31540057 [TBL] [Abstract][Full Text] [Related]
20. The Specificity and Broad Multitarget Properties of Ligands for the Free Fatty Acid Receptors FFA3/GPR41 and FFA2/GPR43 and the Related Hydroxycarboxylic Acid Receptor HCA2/GPR109A. Bisenieks E; Vigante B; Petrovska R; Turovska B; Muhamadejev R; Soloduns V; Velena A; Pajuste K; Saso L; Klovins J; Duburs G; Mandrika I Pharmaceuticals (Basel); 2021 Sep; 14(10):. PubMed ID: 34681211 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]