These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
14. 4-aminopyridyl-based lead compounds targeting CYP51 prevent spontaneous parasite relapse in a chronic model and improve cardiac pathology in an acute model of Trypanosoma cruzi infection. Calvet CM; Choi JY; Thomas D; Suzuki B; Hirata K; Lostracco-Johnson S; de Mesquita LB; Nogueira A; Meuser-Batista M; Silva TA; Siqueira-Neto JL; Roush WR; de Souza Pereira MC; McKerrow JH; Podust LM PLoS Negl Trop Dis; 2017 Dec; 11(12):e0006132. PubMed ID: 29281643 [TBL] [Abstract][Full Text] [Related]
15. Structural basis for rational design of inhibitors targeting Trypanosoma cruzi sterol 14α-demethylase: two regions of the enzyme molecule potentiate its inhibition. Friggeri L; Hargrove TY; Rachakonda G; Williams AD; Wawrzak Z; Di Santo R; De Vita D; Waterman MR; Tortorella S; Villalta F; Lepesheva GI J Med Chem; 2014 Aug; 57(15):6704-17. PubMed ID: 25033013 [TBL] [Abstract][Full Text] [Related]
16. Targeting CYP51 for drug design by the contributions of molecular modeling. Rabelo VW; Santos TF; Terra L; Santana MV; Castro HC; Rodrigues CR; Abreu PA Fundam Clin Pharmacol; 2017 Feb; 31(1):37-53. PubMed ID: 27487199 [TBL] [Abstract][Full Text] [Related]
17. Sterol 14α-Demethylase Structure-Based Optimization of Drug Candidates for Human Infections with the Protozoan Trypanosomatidae. Friggeri L; Hargrove TY; Rachakonda G; Blobaum AL; Fisher P; de Oliveira GM; da Silva CF; Soeiro MNC; Nes WD; Lindsley CW; Villalta F; Guengerich FP; Lepesheva GI J Med Chem; 2018 Dec; 61(23):10910-10921. PubMed ID: 30451500 [TBL] [Abstract][Full Text] [Related]
18. Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections. Xu H; Yan ZZ; Guo MB; An R; Wang X; Zhang R; Mou YH; Hou Z; Guo C Eur J Med Chem; 2021 Apr; 216():113337. PubMed ID: 33713977 [TBL] [Abstract][Full Text] [Related]