BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

259 related articles for article (PubMed ID: 25341566)

  • 21. Induction of human cytochrome P450 3A4 by the irreversible myeloperoxidase inactivator PF-06282999 is mediated by the pregnane X receptor.
    Moscovitz JE; Lin Z; Johnson N; Tu M; Goosen TC; Weng Y; Kalgutkar AS
    Xenobiotica; 2018 Jul; 48(7):647-655. PubMed ID: 28685622
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Role of c-Jun-N-Terminal Kinase in Pregnane X Receptor-Mediated Induction of Human Cytochrome P4503A4 In Vitro.
    Taneja G; Chu C; Maturu P; Moorthy B; Ghose R
    Drug Metab Dispos; 2018 Apr; 46(4):397-404. PubMed ID: 29440179
    [TBL] [Abstract][Full Text] [Related]  

  • 23. PXR-mediated transcriptional activation of CYP3A4 by cryptotanshinone and tanshinone IIA.
    Yu C; Ye S; Sun H; Liu Y; Gao L; Shen C; Chen S; Zeng S
    Chem Biol Interact; 2009 Jan; 177(1):58-64. PubMed ID: 18805405
    [TBL] [Abstract][Full Text] [Related]  

  • 24. A PXR-mediated negative feedback loop attenuates the expression of CYP3A in response to the PXR agonist pregnenalone-16α-carbonitrile.
    Bailey I; Gibson GG; Plant K; Graham M; Plant N
    PLoS One; 2011 Feb; 6(2):e16703. PubMed ID: 21311750
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Polycyclic aromatic hydrocarbons stimulate human CYP3A4 promoter activity via PXR.
    Luckert C; Ehlers A; Buhrke T; Seidel A; Lampen A; Hessel S
    Toxicol Lett; 2013 Oct; 222(2):180-8. PubMed ID: 23845848
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Induction of cytochrome P450 3A by paclitaxel in mice: pivotal role of the nuclear xenobiotic receptor, pregnane X receptor.
    Nallani SC; Goodwin B; Maglich JM; Buckley DJ; Buckley AR; Desai PB
    Drug Metab Dispos; 2003 May; 31(5):681-4. PubMed ID: 12695359
    [TBL] [Abstract][Full Text] [Related]  

  • 27. A human immunodeficiency virus protease inhibitor is a novel functional inhibitor of human pregnane X receptor.
    Healan-Greenberg C; Waring JF; Kempf DJ; Blomme EA; Tirona RG; Kim RB
    Drug Metab Dispos; 2008 Mar; 36(3):500-7. PubMed ID: 18096673
    [TBL] [Abstract][Full Text] [Related]  

  • 28. The pregnane X receptor binds to response elements in a genomic context-dependent manner, and PXR activator rifampicin selectively alters the binding among target genes.
    Song X; Xie M; Zhang H; Li Y; Sachdeva K; Yan B
    Drug Metab Dispos; 2004 Jan; 32(1):35-42. PubMed ID: 14709618
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Dexamethasone induces pregnane X receptor and retinoid X receptor-alpha expression in human hepatocytes: synergistic increase of CYP3A4 induction by pregnane X receptor activators.
    Pascussi JM; Drocourt L; Fabre JM; Maurel P; Vilarem MJ
    Mol Pharmacol; 2000 Aug; 58(2):361-72. PubMed ID: 10908304
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Regulation of cytochrome P450 2C9 expression in primary cultures of human hepatocytes.
    Sahi J; Shord SS; Lindley C; Ferguson S; LeCluyse EL
    J Biochem Mol Toxicol; 2009; 23(1):43-58. PubMed ID: 19202563
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Allyl isothiocyanate (AITC) inhibits pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation and protects against acetaminophen- and amiodarone-induced cytotoxicity.
    Lim YP; Cheng CH; Chen WC; Chang SY; Hung DZ; Chen JJ; Wan L; Ma WC; Lin YH; Chen CY; Yokoi T; Nakajima M; Chen CJ
    Arch Toxicol; 2015 Jan; 89(1):57-72. PubMed ID: 25069801
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Role of human pregnane X receptor in tamoxifen- and 4-hydroxytamoxifen-mediated CYP3A4 induction in primary human hepatocytes and LS174T cells.
    Sane RS; Buckley DJ; Buckley AR; Nallani SC; Desai PB
    Drug Metab Dispos; 2008 May; 36(5):946-54. PubMed ID: 18299335
    [TBL] [Abstract][Full Text] [Related]  

  • 33. The mycoestrogen zearalenone induces CYP3A through activation of the pregnane X receptor.
    Ding X; Lichti K; Staudinger JL
    Toxicol Sci; 2006 Jun; 91(2):448-55. PubMed ID: 16547076
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Regulation of tissue-specific carboxylesterase expression by pregnane x receptor and constitutive androstane receptor.
    Xu C; Wang X; Staudinger JL
    Drug Metab Dispos; 2009 Jul; 37(7):1539-47. PubMed ID: 19359405
    [TBL] [Abstract][Full Text] [Related]  

  • 35. CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes.
    Luo G; Cunningham M; Kim S; Burn T; Lin J; Sinz M; Hamilton G; Rizzo C; Jolley S; Gilbert D; Downey A; Mudra D; Graham R; Carroll K; Xie J; Madan A; Parkinson A; Christ D; Selling B; LeCluyse E; Gan LS
    Drug Metab Dispos; 2002 Jul; 30(7):795-804. PubMed ID: 12065438
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Endosulfan induces CYP2B6 and CYP3A4 by activating the pregnane X receptor.
    Casabar RC; Das PC; Dekrey GK; Gardiner CS; Cao Y; Rose RL; Wallace AD
    Toxicol Appl Pharmacol; 2010 Jun; 245(3):335-43. PubMed ID: 20361990
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Pregnane X receptor-mediated induction of Cyp3a by black cohosh.
    Pang X; Cheng J; Krausz KW; Guo DA; Gonzalez FJ
    Xenobiotica; 2011 Feb; 41(2):112-23. PubMed ID: 20979450
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Functional characterization of four naturally occurring variants of human pregnane X receptor (PXR): one variant causes dramatic loss of both DNA binding activity and the transactivation of the CYP3A4 promoter/enhancer region.
    Koyano S; Kurose K; Saito Y; Ozawa S; Hasegawa R; Komamura K; Ueno K; Kamakura S; Kitakaze M; Nakajima T; Matsumoto K; Akasawa A; Saito H; Sawada J
    Drug Metab Dispos; 2004 Jan; 32(1):149-54. PubMed ID: 14709632
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Byakangelicin induces cytochrome P450 3A4 expression via transactivation of pregnane X receptors in human hepatocytes.
    Yang J; Luan X; Gui H; Yan P; Yang D; Song X; Liu W; Hu G; Yan B
    Br J Pharmacol; 2011 Jan; 162(2):441-51. PubMed ID: 20942813
    [TBL] [Abstract][Full Text] [Related]  

  • 40. A human and mouse pregnane X receptor reporter gene assay in combination with cytotoxicity measurements as a tool to evaluate species-specific CYP3A induction.
    Vignati LA; Bogni A; Grossi P; Monshouwer M
    Toxicology; 2004 Jun; 199(1):23-33. PubMed ID: 15125996
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 13.