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22. p53 deficiency enhances mitotic arrest and slippage induced by pharmacological inhibition of Aurora kinases. Marxer M; Ma HT; Man WY; Poon RY Oncogene; 2014 Jul; 33(27):3550-60. PubMed ID: 23955083 [TBL] [Abstract][Full Text] [Related]
23. Pro-apoptotic and pro-autophagic effects of the Aurora kinase A inhibitor alisertib (MLN8237) on human osteosarcoma U-2 OS and MG-63 cells through the activation of mitochondria-mediated pathway and inhibition of p38 MAPK/PI3K/Akt/mTOR signaling pathway. Niu NK; Wang ZL; Pan ST; Ding HQ; Au GH; He ZX; Zhou ZW; Xiao G; Yang YX; Zhang X; Yang T; Chen XW; Qiu JX; Zhou SF Drug Des Devel Ther; 2015; 9():1555-84. PubMed ID: 25792811 [TBL] [Abstract][Full Text] [Related]
24. Aurora kinases are a novel therapeutic target for HPV-positive head and neck cancers. Shaikh MH; Idris A; Johnson NW; Fallaha S; Clarke DTW; Martin D; Morgan IM; Gabrielli B; McMillan NAJ Oral Oncol; 2018 Nov; 86():105-112. PubMed ID: 30409290 [TBL] [Abstract][Full Text] [Related]
25. Preclinical testing of selective Aurora kinase inhibitors on a medullary thyroid carcinoma-derived cell line. Tuccilli C; Baldini E; Prinzi N; Morrone S; Sorrenti S; Filippini A; Catania A; Alessandrini S; Rendina R; Coccaro C; D'Armiento M; Ulisse S Endocrine; 2016 May; 52(2):287-95. PubMed ID: 26215279 [TBL] [Abstract][Full Text] [Related]
26. Alisertib induces cell cycle arrest and autophagy and suppresses epithelial-to-mesenchymal transition involving PI3K/Akt/mTOR and sirtuin 1-mediated signaling pathways in human pancreatic cancer cells. Wang F; Li H; Yan XG; Zhou ZW; Yi ZG; He ZX; Pan ST; Yang YX; Wang ZZ; Zhang X; Yang T; Qiu JX; Zhou SF Drug Des Devel Ther; 2015; 9():575-601. PubMed ID: 25632225 [TBL] [Abstract][Full Text] [Related]
27. Aurkin-A, a TPX2-Aurora A small molecule inhibitor disrupts Alisertib-induced polyploidy in aggressive diffuse large B cell lymphoma. Conway PJ; De La Peña Avalos B; Dao J; Montagnino S; Kovalskyy D; Dray E; Mahadevan D Neoplasia; 2024 Sep; 55():101014. PubMed ID: 38875929 [TBL] [Abstract][Full Text] [Related]
28. Combined Aurora Kinase A (AURKA) and WEE1 Inhibition Demonstrates Synergistic Antitumor Effect in Squamous Cell Carcinoma of the Head and Neck. Lee JW; Parameswaran J; Sandoval-Schaefer T; Eoh KJ; Yang DH; Zhu F; Mehra R; Sharma R; Gaffney SG; Perry EB; Townsend JP; Serebriiskii IG; Golemis EA; Issaeva N; Yarbrough WG; Koo JS; Burtness B Clin Cancer Res; 2019 Jun; 25(11):3430-3442. PubMed ID: 30755439 [TBL] [Abstract][Full Text] [Related]
29. Combining an Aurora Kinase Inhibitor and a Death Receptor Ligand/Agonist Antibody Triggers Apoptosis in Melanoma Cells and Prevents Tumor Growth in Preclinical Mouse Models. Liu Y; Hawkins OE; Vilgelm AE; Pawlikowski JS; Ecsedy JA; Sosman JA; Kelley MC; Richmond A Clin Cancer Res; 2015 Dec; 21(23):5338-48. PubMed ID: 26152738 [TBL] [Abstract][Full Text] [Related]
30. Inhibition of the Aurora A kinase augments the anti-tumor efficacy of oncolytic measles virotherapy. Iankov ID; Kurokawa CB; D'Assoro AB; Ingle JN; Domingo-Musibay E; Allen C; Crosby CM; Nair AA; Liu MC; Aderca I; Federspiel MJ; Galanis E Cancer Gene Ther; 2015 Sep; 22(9):438-44. PubMed ID: 26272026 [TBL] [Abstract][Full Text] [Related]
31. Combination of Eribulin and Aurora A Inhibitor MLN8237 Prevents Metastatic Colonization and Induces Cytotoxic Autophagy in Breast Cancer. Kozyreva VK; Kiseleva AA; Ice RJ; Jones BC; Loskutov YV; Matalkah F; Smolkin MB; Marinak K; Livengood RH; Salkeni MA; Wen S; Hazard HW; Layne GP; Walsh CM; Cantrell PS; Kilby GW; Mahavadi S; Shah N; Pugacheva EN Mol Cancer Ther; 2016 Aug; 15(8):1809-22. PubMed ID: 27235164 [TBL] [Abstract][Full Text] [Related]
32. Targeting aurora kinases limits tumour growth through DNA damage-mediated senescence and blockade of NF-κB impairs this drug-induced senescence. Liu Y; Hawkins OE; Su Y; Vilgelm AE; Sobolik T; Thu YM; Kantrow S; Splittgerber RC; Short S; Amiri KI; Ecsedy JA; Sosman JA; Kelley MC; Richmond A EMBO Mol Med; 2013 Jan; 5(1):149-66. PubMed ID: 23180582 [TBL] [Abstract][Full Text] [Related]
33. Aurora kinase A mediates epithelial ovarian cancer cell migration and adhesion. Do TV; Xiao F; Bickel LE; Klein-Szanto AJ; Pathak HB; Hua X; Howe C; O'Brien SW; Maglaty M; Ecsedy JA; Litwin S; Golemis EA; Schilder RJ; Godwin AK; Connolly DC Oncogene; 2014 Jan; 33(5):539-49. PubMed ID: 23334327 [TBL] [Abstract][Full Text] [Related]
34. Alisertib induces apoptosis and autophagy through targeting the AKT/mTOR/AMPK/p38 pathway in leukemic cells. Fu Y; Zhang Y; Gao M; Quan L; Gui R; Liu J Mol Med Rep; 2016 Jul; 14(1):394-8. PubMed ID: 27177156 [TBL] [Abstract][Full Text] [Related]
35. Aurora kinase a inhibitor MLN8237 suppresses pancreatic cancer growth. Zhang Y; Ma Y; Wang Y; Mukhopadhyay D; Bi Y; Ji B Pancreatology; 2022 Jun; 22(5):619-625. PubMed ID: 35550115 [TBL] [Abstract][Full Text] [Related]
36. The CNS penetrating taxane TPI 287 and the AURKA inhibitor alisertib induce synergistic apoptosis in glioblastoma cells. Zumbar CT; Usubalieva A; King PD; Li X; Mifsud CS; Dalton HM; Sak M; Urio S; Bryant WM; McElroy JP; Farmer G; Lehman NL J Neurooncol; 2018 May; 137(3):481-492. PubMed ID: 29396807 [TBL] [Abstract][Full Text] [Related]
37. c-Myc Is a Major Determinant for Antitumor Activity of Aurora A Kinase Inhibitor MLN8237 in Thyroid Cancer. Li Y; Li X; Pu J; Yang Q; Guan H; Ji M; Shi B; Chen M; Hou P Thyroid; 2018 Dec; 28(12):1642-1654. PubMed ID: 30226440 [No Abstract] [Full Text] [Related]
38. Alisertib (MLN8237) an investigational agent suppresses Aurora A and B activity, inhibits proliferation, promotes endo-reduplication and induces apoptosis in T-NHL cell lines supporting its importance in PTCL treatment. Qi W; Spier C; Liu X; Agarwal A; Cooke LS; Persky DO; Chen D; Miller TP; Mahadevan D Leuk Res; 2013 Apr; 37(4):434-9. PubMed ID: 23153524 [TBL] [Abstract][Full Text] [Related]
39. Cisplatin-resistant cancer cells are sensitive to Aurora kinase A inhibition by alisertib. Wang L; Arras J; Katsha A; Hamdan S; Belkhiri A; Ecsedy J; El-Rifai W Mol Oncol; 2017 Aug; 11(8):981-995. PubMed ID: 28417568 [TBL] [Abstract][Full Text] [Related]
40. Initial testing of the aurora kinase A inhibitor MLN8237 by the Pediatric Preclinical Testing Program (PPTP). Maris JM; Morton CL; Gorlick R; Kolb EA; Lock R; Carol H; Keir ST; Reynolds CP; Kang MH; Wu J; Smith MA; Houghton PJ Pediatr Blood Cancer; 2010 Jul; 55(1):26-34. PubMed ID: 20108338 [TBL] [Abstract][Full Text] [Related] [Previous] [Next] [New Search]