172 related articles for article (PubMed ID: 25366484)
1. Human hepatocarcinoma functional liver cell-4 cell line exhibits high expression of drug-metabolizing enzymes in three-dimensional culture.
Kato R; Shigemoto K; Akiyama H; Ieda A; Ijiri Y; Hayashi T
Biol Pharm Bull; 2014; 37(11):1782-7. PubMed ID: 25366484
[TBL] [Abstract][Full Text] [Related]
2. Increased expression of drug-metabolizing enzymes in human hepatocarcinoma FLC-4 cells cultured on micro-space cell culture plates.
Kobayashi K; Yoshida A; Ejiri Y; Takagi S; Mimura H; Hosoda M; Matsuura T; Chiba K
Drug Metab Pharmacokinet; 2012; 27(5):478-85. PubMed ID: 22447115
[TBL] [Abstract][Full Text] [Related]
3. Cytochrome P450 enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HepG2 cells.
Westerink WM; Schoonen WG
Toxicol In Vitro; 2007 Dec; 21(8):1581-91. PubMed ID: 17637504
[TBL] [Abstract][Full Text] [Related]
4. CYP3A4 inducible model for in vitro analysis of human drug metabolism using a bioartificial liver.
Iwahori T; Matsuura T; Maehashi H; Sugo K; Saito M; Hosokawa M; Chiba K; Masaki T; Aizaki H; Ohkawa K; Suzuki T
Hepatology; 2003 Mar; 37(3):665-73. PubMed ID: 12601364
[TBL] [Abstract][Full Text] [Related]
5. Significantly decreased and more variable expression of major CYPs and UGTs in liver microsomes prepared from HBV-positive human hepatocellular carcinoma and matched pericarcinomatous tissues determined using an isotope label-free UPLC-MS/MS method.
Yan T; Gao S; Peng X; Shi J; Xie C; Li Q; Lu L; Wang Y; Zhou F; Liu Z; Hu M
Pharm Res; 2015 Mar; 32(3):1141-57. PubMed ID: 25288013
[TBL] [Abstract][Full Text] [Related]
6. Phenobarbital regulates nuclear expression of HNF-4alpha in mouse and rat hepatocytes independent of CAR and PXR.
Bell AW; Michalopoulos GK
Hepatology; 2006 Jul; 44(1):186-94. PubMed ID: 16799975
[TBL] [Abstract][Full Text] [Related]
7. Transcriptional activation of PPARalpha by phenobarbital in the absence of CAR and PXR.
Tamasi V; Juvan P; Beer M; Rozman D; Meyer UA
Mol Pharm; 2009; 6(5):1573-81. PubMed ID: 19708687
[TBL] [Abstract][Full Text] [Related]
8. Cytochrome P450 expression in human hepatocytes and hepatoma cell lines: molecular mechanisms that determine lower expression in cultured cells.
Rodríguez-Antona C; Donato MT; Boobis A; Edwards RJ; Watts PS; Castell JV; Gómez-Lechón MJ
Xenobiotica; 2002 Jun; 32(6):505-20. PubMed ID: 12160483
[TBL] [Abstract][Full Text] [Related]
9. The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics.
Guillouzo A; Corlu A; Aninat C; Glaise D; Morel F; Guguen-Guillouzo C
Chem Biol Interact; 2007 May; 168(1):66-73. PubMed ID: 17241619
[TBL] [Abstract][Full Text] [Related]
10. Renal drug metabolism in humans: the potential for drug-endobiotic interactions involving cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT).
Knights KM; Rowland A; Miners JO
Br J Clin Pharmacol; 2013 Oct; 76(4):587-602. PubMed ID: 23362865
[TBL] [Abstract][Full Text] [Related]
11. A novel human hepatoma cell line, FLC-4, exhibits highly enhanced liver differentiation functions through the three-dimensional cell shape.
Laurent T; Murase D; Tsukioka S; Matsuura T; Nagamori S; Oda H
J Cell Physiol; 2012 Jul; 227(7):2898-906. PubMed ID: 21960466
[TBL] [Abstract][Full Text] [Related]
12. Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells.
Aninat C; Piton A; Glaise D; Le Charpentier T; Langouët S; Morel F; Guguen-Guillouzo C; Guillouzo A
Drug Metab Dispos; 2006 Jan; 34(1):75-83. PubMed ID: 16204462
[TBL] [Abstract][Full Text] [Related]
13. Genetic polymorphisms in the TATA box and upstream phenobarbital-responsive enhancer module of the UGT1A1 promoter have combined effects on UDP-glucuronosyltransferase 1A1 transcription mediated by constitutive androstane receptor, pregnane X receptor, or glucocorticoid receptor in human liver.
Li Y; Buckley D; Wang S; Klaassen CD; Zhong XB
Drug Metab Dispos; 2009 Sep; 37(9):1978-86. PubMed ID: 19541828
[TBL] [Abstract][Full Text] [Related]
14. Effect of hypoxia on UDP-glucuronosyl transferase mRNA expression in human hepatocarcinoma functional liver celL4 cell line.
Kato R; Matsura A; Kamiya R; Oishi C; Kagawa Y; Tanaka F; Matsumoto N; Ijiri Y; Hayashi T
Pharmazie; 2016 Mar; 71(3):152-3. PubMed ID: 27183710
[TBL] [Abstract][Full Text] [Related]
15. Hepatic biotransformation of non-psychotropic phytocannabinoids and activity screening on cytochromes P450 and UDP-glucuronosyltransferases.
Havlasek J; Vrba J; Zatloukalova M; Papouskova B; Modriansky M; Storch J; Vacek J
Toxicol Appl Pharmacol; 2023 Oct; 476():116654. PubMed ID: 37574147
[TBL] [Abstract][Full Text] [Related]
16. Up-regulation of CYP expression in hepatoma cells stably transfected by chimeric nuclear receptors.
Küblbeck J; Reinisalo M; Mustonen R; Honkakoski P
Eur J Pharm Sci; 2010 Jul; 40(4):263-72. PubMed ID: 20381613
[TBL] [Abstract][Full Text] [Related]
17. Differences in Gene Regulation by Dual Ligands of Nuclear Receptors Constitutive Androstane Receptor (CAR) and Pregnane X Receptor (PXR) in HepG2 Cells Stably Expressing CAR/PXR.
Kanno Y; Tanuma N; Yazawa S; Zhao S; Inaba M; Nakamura S; Nemoto K; Inouye Y
Drug Metab Dispos; 2016 Aug; 44(8):1158-63. PubMed ID: 27197997
[TBL] [Abstract][Full Text] [Related]
18. Ketoconazole and miconazole are antagonists of the human glucocorticoid receptor: consequences on the expression and function of the constitutive androstane receptor and the pregnane X receptor.
Duret C; Daujat-Chavanieu M; Pascussi JM; Pichard-Garcia L; Balaguer P; Fabre JM; Vilarem MJ; Maurel P; Gerbal-Chaloin S
Mol Pharmacol; 2006 Jul; 70(1):329-39. PubMed ID: 16608920
[TBL] [Abstract][Full Text] [Related]
19. Rifampicin induction of CYP3A4 requires pregnane X receptor cross talk with hepatocyte nuclear factor 4alpha and coactivators, and suppression of small heterodimer partner gene expression.
Li T; Chiang JY
Drug Metab Dispos; 2006 May; 34(5):756-64. PubMed ID: 16455805
[TBL] [Abstract][Full Text] [Related]
20. Suppression of the pregnane X receptor during endoplasmic reticulum stress is achieved by down-regulating hepatocyte nuclear factor-4α and up-regulating liver-enriched inhibitory protein.
Vachirayonsti T; Ho KW; Yang D; Yan B
Toxicol Sci; 2015 Apr; 144(2):382-92. PubMed ID: 25616597
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
