These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

174 related articles for article (PubMed ID: 25375781)

  • 1. Positive allosteric modulators of 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid receptors belonging to 4-cyclopropyl-3,4-dihydro-2h-1,2,4-pyridothiadiazine dioxides and diversely chloro-substituted 4-cyclopropyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides.
    Francotte P; Nørholm AB; Deva T; Olsen L; Frydenvang K; Goffin E; Fraikin P; de Tullio P; Challal S; Thomas JY; Iop F; Louis C; Botez-Pop I; Lestage P; Danober L; Kastrup JS; Pirotte B
    J Med Chem; 2014 Nov; 57(22):9539-53. PubMed ID: 25375781
    [TBL] [Abstract][Full Text] [Related]  

  • 2. 4H-1,2,4-Pyridothiadiazine 1,1-dioxides and 2,3-dihydro-4H-1,2, 4-pyridothiadiazine 1,1-dioxides chemically related to diazoxide and cyclothiazide as powerful positive allosteric modulators of (R/S)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid receptors: design, synthesis, pharmacology, and structure-activity relationships.
    Pirotte B; Podona T; Diouf O; de Tullio P; Lebrun P; Dupont L; Somers F; Delarge J; Morain P; Lestage P; Lepagnol J; Spedding M
    J Med Chem; 1998 Jul; 41(16):2946-59. PubMed ID: 9685234
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Synthesis and Pharmacology of Mono-, Di-, and Trialkyl-Substituted 7-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides Combined with X-ray Structure Analysis to Understand the Unexpected Structure-Activity Relationship at AMPA Receptors.
    Larsen AP; Francotte P; Frydenvang K; Tapken D; Goffin E; Fraikin P; Caignard DH; Lestage P; Danober L; Pirotte B; Kastrup JS
    ACS Chem Neurosci; 2016 Mar; 7(3):378-90. PubMed ID: 26771108
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Development of thiophenic analogues of benzothiadiazine dioxides as new powerful potentiators of 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA) receptors.
    Francotte P; Goffin E; Fraikin P; Graindorge E; Lestage P; Danober L; Challal S; Rogez N; Nosjean O; Caignard DH; Pirotte B; de Tullio P
    J Med Chem; 2013 Oct; 56(20):7838-50. PubMed ID: 24090223
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Design, synthesis, and pharmacology of novel 7-substituted 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides as positive allosteric modulators of AMPA receptors.
    Francotte P; Tullio Pd; Goffin E; Dintilhac G; Graindorge E; Fraikin P; Lestage P; Danober L; Thomas JY; Caignard DH; Pirotte B
    J Med Chem; 2007 Jun; 50(13):3153-7. PubMed ID: 17552506
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Exploring thienothiadiazine dioxides as isosteric analogues of benzo- and pyridothiadiazine dioxides in the search of new AMPA and kainate receptor positive allosteric modulators.
    Francotte P; Bay Y; Goffin E; Colson T; Lesenfants C; Dorosz J; Laulumaa S; Fraikin P; de Tullio P; Beaufour C; Botez I; Pickering DS; Frydenvang K; Danober L; Kristensen AS; Kastrup JS; Pirotte B
    Eur J Med Chem; 2024 Jan; 264():116036. PubMed ID: 38101041
    [TBL] [Abstract][Full Text] [Related]  

  • 7. 7-Phenoxy-Substituted 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides as Positive Allosteric Modulators of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Nanomolar Potency.
    Goffin E; Drapier T; Larsen AP; Geubelle P; Ptak CP; Laulumaa S; Rovinskaja K; Gilissen J; Tullio P; Olsen L; Frydenvang K; Pirotte B; Hanson J; Oswald RE; Kastrup JS; Francotte P
    J Med Chem; 2018 Jan; 61(1):251-264. PubMed ID: 29256599
    [TBL] [Abstract][Full Text] [Related]  

  • 8. New insights in the development of positive allosteric modulators of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors belonging to 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides: Introduction of (mono/difluoro)methyl groups at the 2-position of the thiadiazine ring.
    Goffin E; Fraikin P; Abboud D; de Tullio P; Beaufour C; Botez I; Hanson J; Danober L; Francotte P; Pirotte B
    Eur J Med Chem; 2023 Mar; 250():115221. PubMed ID: 36863228
    [TBL] [Abstract][Full Text] [Related]  

  • 9. New fluorinated 1,2,4-benzothiadiazine 1,1-dioxides: discovery of an orally active cognitive enhancer acting through potentiation of the 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid receptors.
    Francotte P; Goffin E; Fraikin P; Lestage P; Van Heugen JC; Gillotin F; Danober L; Thomas JY; Chiap P; Caignard DH; Pirotte B; de Tullio P
    J Med Chem; 2010 Feb; 53(4):1700-11. PubMed ID: 20108934
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthesis, pharmacological and structural characterization, and thermodynamic aspects of GluA2-positive allosteric modulators with a 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide scaffold.
    Nørholm AB; Francotte P; Olsen L; Krintel C; Frydenvang K; Goffin E; Challal S; Danober L; Botez-Pop I; Lestage P; Pirotte B; Kastrup JS
    J Med Chem; 2013 Nov; 56(21):8736-45. PubMed ID: 24131202
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Development of Thiochroman Dioxide Analogues of Benzothiadiazine Dioxides as New Positive Allosteric Modulators of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors.
    Etsè KS; Dorosz J; McLain Christensen K; Thomas JY; Botez Pop I; Goffin E; Colson T; Lestage P; Danober L; Pirotte B; Kastrup JS; Francotte P
    ACS Chem Neurosci; 2021 Jul; 12(14):2679-2692. PubMed ID: 34242002
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Synthesis and pharmacological evaluation of a second generation of pyridothiadiazine 1,1-dioxides acting as AMPA potentiators.
    Francotte P; de Tullio P; Podona T; Diouf O; Fraikin P; Lestage P; Danober L; Thomas JY; Caignard DH; Pirotte B
    Bioorg Med Chem; 2008 Dec; 16(23):9948-56. PubMed ID: 18980844
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Hydroxylated analogues of ATP-sensitive potassium channel openers belonging to the group of 6- and/or 7-substituted 3-isopropylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides: toward an improvement in sulfonylurea receptor 1 selectivity and metabolism stability.
    de Tullio P; Servais AC; Fillet M; Gillotin F; Somers F; Chiap P; Lebrun P; Pirotte B
    J Med Chem; 2011 Dec; 54(24):8353-61. PubMed ID: 22077416
    [TBL] [Abstract][Full Text] [Related]  

  • 14. 7-Chloro-5-(furan-3-yl)-3-methyl-4H-benzo[e][1,2,4]thiadiazine 1,1-Dioxide as Positive Allosteric Modulator of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor. The End of the Unsaturated-Inactive Paradigm?
    Citti C; Battisti UM; Cannazza G; Jozwiak K; Stasiak N; Puja G; Ravazzini F; Ciccarella G; Braghiroli D; Parenti C; Troisi L; Zoli M
    ACS Chem Neurosci; 2016 Feb; 7(2):149-60. PubMed ID: 26580317
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Enhancing Action of Positive Allosteric Modulators through the Design of Dimeric Compounds.
    Drapier T; Geubelle P; Bouckaert C; Nielsen L; Laulumaa S; Goffin E; Dilly S; Francotte P; Hanson J; Pochet L; Kastrup JS; Pirotte B
    J Med Chem; 2018 Jun; 61(12):5279-5291. PubMed ID: 29775064
    [TBL] [Abstract][Full Text] [Related]  

  • 16. 7-Chloro-3-methyl-3-4-dihydro-2H-1,2,4 benzothiadiazine S,S-dioxide (IDRA 21): a benzothiadiazine derivative that enhances cognition by attenuating DL-alpha-amino-2,3-dihydro-5-methyl-3-oxo-4-isoxazolepropanoic acid (AMPA) receptor desensitization.
    Zivkovic I; Thompson DM; Bertolino M; Uzunov D; DiBella M; Costa E; Guidotti A
    J Pharmacol Exp Ther; 1995 Jan; 272(1):300-9. PubMed ID: 7815345
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Chloro-substituted 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as ATP-sensitive potassium channel activators: impact of the position of the chlorine atom on the aromatic ring on activity and tissue selectivity.
    Pirotte B; de Tullio P; Nguyen QA; Somers F; Fraikin P; Florence X; Wahl P; Hansen JB; Lebrun P
    J Med Chem; 2010 Jan; 53(1):147-54. PubMed ID: 19919106
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Identification and Structure-Function Study of Positive Allosteric Modulators of Kainate Receptors.
    Larsen AP; Fièvre S; Frydenvang K; Francotte P; Pirotte B; Kastrup JS; Mulle C
    Mol Pharmacol; 2017 Jun; 91(6):576-585. PubMed ID: 28360094
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Impact of the nature of the substituent at the 3-position of 4H-1,2,4-benzothiadiazine 1,1-dioxides on their opening activity toward ATP-sensitive potassium channels.
    Pirotte B; de Tullio P; Boverie S; Michaux C; Lebrun P
    J Med Chem; 2011 May; 54(9):3188-99. PubMed ID: 21428460
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Distinct structural features of cyclothiazide are responsible for effects on peak current amplitude and desensitization kinetics at iGluR2.
    Hald H; Ahring PK; Timmermann DB; Liljefors T; Gajhede M; Kastrup JS
    J Mol Biol; 2009 Sep; 391(5):906-17. PubMed ID: 19591837
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.