BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

252 related articles for article (PubMed ID: 25378409)

  • 1. Multiple drugs compete for transport via the Plasmodium falciparum chloroquine resistance transporter at distinct but interdependent sites.
    Bellanca S; Summers RL; Meyrath M; Dave A; Nash MN; Dittmer M; Sanchez CP; Stein WD; Martin RE; Lanzer M
    J Biol Chem; 2014 Dec; 289(52):36336-51. PubMed ID: 25378409
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Chloroquine transport via the malaria parasite's chloroquine resistance transporter.
    Martin RE; Marchetti RV; Cowan AI; Howitt SM; Bröer S; Kirk K
    Science; 2009 Sep; 325(5948):1680-2. PubMed ID: 19779197
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Verapamil-Sensitive Transport of Quinacrine and Methylene Blue via the Plasmodium falciparum Chloroquine Resistance Transporter Reduces the Parasite's Susceptibility to these Tricyclic Drugs.
    van Schalkwyk DA; Nash MN; Shafik SH; Summers RL; Lehane AM; Smith PJ; Martin RE
    J Infect Dis; 2016 Mar; 213(5):800-10. PubMed ID: 26503982
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Molecular Mechanisms for Drug Hypersensitivity Induced by the Malaria Parasite's Chloroquine Resistance Transporter.
    Richards SN; Nash MN; Baker ES; Webster MW; Lehane AM; Shafik SH; Martin RE
    PLoS Pathog; 2016 Jul; 12(7):e1005725. PubMed ID: 27441371
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Iron is a substrate of the
    Bakouh N; Bellanca S; Nyboer B; Moliner Cubel S; Karim Z; Sanchez CP; Stein WD; Planelles G; Lanzer M
    J Biol Chem; 2017 Sep; 292(39):16109-16121. PubMed ID: 28768767
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Phosphomimetic substitution at Ser-33 of the chloroquine resistance transporter PfCRT reconstitutes drug responses in
    Sanchez CP; Moliner Cubel S; Nyboer B; Jankowska-Döllken M; Schaeffer-Reiss C; Ayoub D; Planelles G; Lanzer M
    J Biol Chem; 2019 Aug; 294(34):12766-12778. PubMed ID: 31285265
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Quinine dimers are potent inhibitors of the Plasmodium falciparum chloroquine resistance transporter and are active against quinoline-resistant P. falciparum.
    Hrycyna CA; Summers RL; Lehane AM; Pires MM; Namanja H; Bohn K; Kuriakose J; Ferdig M; Henrich PP; Fidock DA; Kirk K; Chmielewski J; Martin RE
    ACS Chem Biol; 2014 Mar; 9(3):722-30. PubMed ID: 24369685
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations.
    Sidhu AB; Verdier-Pinard D; Fidock DA
    Science; 2002 Oct; 298(5591):210-3. PubMed ID: 12364805
    [TBL] [Abstract][Full Text] [Related]  

  • 9. A 2-amino quinoline, 5-(3-(2-(7-chloroquinolin-2-yl)ethenyl)phenyl)-8-dimethylcarbamyl-4,6-dithiaoctanoic acid, interacts with PfMDR1 and inhibits its drug transport in Plasmodium falciparum.
    Edaye S; Reiling SJ; Leimanis ML; Wunderlich J; Rohrbach P; Georges E
    Mol Biochem Parasitol; 2014 Jun; 195(1):34-42. PubMed ID: 24914817
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Functional characteristics of the malaria parasite's "chloroquine resistance transporter": implications for chemotherapy.
    Summers RL; Martin RE
    Virulence; 2010; 1(4):304-8. PubMed ID: 21178460
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Glutathione transport: a new role for PfCRT in chloroquine resistance.
    Patzewitz EM; Salcedo-Sora JE; Wong EH; Sethia S; Stocks PA; Maughan SC; Murray JA; Krishna S; Bray PG; Ward SA; Müller S
    Antioxid Redox Signal; 2013 Sep; 19(7):683-95. PubMed ID: 23256874
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Mutations in transmembrane domains 1, 4 and 9 of the Plasmodium falciparum chloroquine resistance transporter alter susceptibility to chloroquine, quinine and quinidine.
    Cooper RA; Lane KD; Deng B; Mu J; Patel JJ; Wellems TE; Su X; Ferdig MT
    Mol Microbiol; 2007 Jan; 63(1):270-82. PubMed ID: 17163969
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Efflux of a range of antimalarial drugs and 'chloroquine resistance reversers' from the digestive vacuole in malaria parasites with mutant PfCRT.
    Lehane AM; Kirk K
    Mol Microbiol; 2010 Aug; 77(4):1039-51. PubMed ID: 20598081
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The antimalarial drug resistance protein Plasmodium falciparum chloroquine resistance transporter binds chloroquine.
    Zhang H; Paguio M; Roepe PD
    Biochemistry; 2004 Jul; 43(26):8290-6. PubMed ID: 15222741
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Alternative mutations at position 76 of the vacuolar transmembrane protein PfCRT are associated with chloroquine resistance and unique stereospecific quinine and quinidine responses in Plasmodium falciparum.
    Cooper RA; Ferdig MT; Su XZ; Ursos LM; Mu J; Nomura T; Fujioka H; Fidock DA; Roepe PD; Wellems TE
    Mol Pharmacol; 2002 Jan; 61(1):35-42. PubMed ID: 11752204
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Functional Comparison of 45 Naturally Occurring Isoforms of the Plasmodium falciparum Chloroquine Resistance Transporter (PfCRT).
    Callaghan PS; Hassett MR; Roepe PD
    Biochemistry; 2015 Aug; 54(32):5083-94. PubMed ID: 26208441
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Dictyostelium discoideum expresses a malaria chloroquine resistance mechanism upon transfection with mutant, but not wild-type, Plasmodium falciparum transporter PfCRT.
    Naudé B; Brzostowski JA; Kimmel AR; Wellems TE
    J Biol Chem; 2005 Jul; 280(27):25596-603. PubMed ID: 15883156
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, enlarge the parasite's food vacuole and alter drug sensitivities.
    Pulcini S; Staines HM; Lee AH; Shafik SH; Bouyer G; Moore CM; Daley DA; Hoke MJ; Altenhofen LM; Painter HJ; Mu J; Ferguson DJ; Llinás M; Martin RE; Fidock DA; Cooper RA; Krishna S
    Sci Rep; 2015 Sep; 5():14552. PubMed ID: 26420308
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A critical role for PfCRT K76T in Plasmodium falciparum verapamil-reversible chloroquine resistance.
    Lakshmanan V; Bray PG; Verdier-Pinard D; Johnson DJ; Horrocks P; Muhle RA; Alakpa GE; Hughes RH; Ward SA; Krogstad DJ; Sidhu AB; Fidock DA
    EMBO J; 2005 Jul; 24(13):2294-305. PubMed ID: 15944738
    [TBL] [Abstract][Full Text] [Related]  

  • 20. In silico modeling of Plasmodium falciparum chloroquine resistance transporter protein and biochemical studies suggest its key contribution to chloroquine resistance.
    Antony HA; Topno NS; Gummadi SN; Siva Sankar D; Krishna R; Parija SC
    Acta Trop; 2019 Jan; 189():84-93. PubMed ID: 30308208
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.