BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

2033 related articles for article (PubMed ID: 25383517)

  • 1. Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS.
    Chouchani ET; Pell VR; Gaude E; Aksentijević D; Sundier SY; Robb EL; Logan A; Nadtochiy SM; Ord ENJ; Smith AC; Eyassu F; Shirley R; Hu CH; Dare AJ; James AM; Rogatti S; Hartley RC; Eaton S; Costa ASH; Brookes PS; Davidson SM; Duchen MR; Saeb-Parsy K; Shattock MJ; Robinson AJ; Work LM; Frezza C; Krieg T; Murphy MP
    Nature; 2014 Nov; 515(7527):431-435. PubMed ID: 25383517
    [TBL] [Abstract][Full Text] [Related]  

  • 2. A model of mitochondrial superoxide production during ischaemia-reperfusion injury for therapeutic development and mechanistic understanding.
    Sorby-Adams A; Prime TA; Miljkovic JL; Prag HA; Krieg T; Murphy MP
    Redox Biol; 2024 Jun; 72():103161. PubMed ID: 38677214
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Pre-ischaemic mitochondrial substrate constraint by inhibition of malate-aspartate shuttle preserves mitochondrial function after ischaemia-reperfusion.
    Jespersen NR; Yokota T; Støttrup NB; Bergdahl A; Paelestik KB; Povlsen JA; Dela F; Bøtker HE
    J Physiol; 2017 Jun; 595(12):3765-3780. PubMed ID: 28093764
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Increased Succinate Accumulation Induces ROS Generation in
    Kamarauskaite J; Baniene R; Trumbeckas D; Strazdauskas A; Trumbeckaite S
    Biomed Res Int; 2020; 2020():8855585. PubMed ID: 33102598
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Ischemic preconditioning protects against cardiac ischemia reperfusion injury without affecting succinate accumulation or oxidation.
    Pell VR; Spiroski AM; Mulvey J; Burger N; Costa ASH; Logan A; Gruszczyk AV; Rosa T; James AM; Frezza C; Murphy MP; Krieg T
    J Mol Cell Cardiol; 2018 Oct; 123():88-91. PubMed ID: 30118790
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Succinate metabolism: a new therapeutic target for myocardial reperfusion injury.
    Pell VR; Chouchani ET; Frezza C; Murphy MP; Krieg T
    Cardiovasc Res; 2016 Jul; 111(2):134-41. PubMed ID: 27194563
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Inhibition of the malate-aspartate shuttle by pre-ischaemic aminooxyacetate loading of the heart induces cardioprotection.
    Støttrup NB; Løfgren B; Birkler RD; Nielsen JM; Wang L; Caldarone CA; Kristiansen SB; Contractor H; Johannsen M; Bøtker HE; Nielsen TT
    Cardiovasc Res; 2010 Nov; 88(2):257-66. PubMed ID: 20562422
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Mechanism of succinate efflux upon reperfusion of the ischaemic heart.
    Prag HA; Gruszczyk AV; Huang MM; Beach TE; Young T; Tronci L; Nikitopoulou E; Mulvey JF; Ascione R; Hadjihambi A; Shattock MJ; Pellerin L; Saeb-Parsy K; Frezza C; James AM; Krieg T; Murphy MP; Aksentijević D
    Cardiovasc Res; 2021 Mar; 117(4):1188-1201. PubMed ID: 32766828
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Inhibiting Succinate Release Worsens Cardiac Reperfusion Injury by Enhancing Mitochondrial Reactive Oxygen Species Generation.
    Milliken AS; Nadtochiy SM; Brookes PS
    J Am Heart Assoc; 2022 Jul; 11(13):e026135. PubMed ID: 35766275
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Inhibition of pyruvate dehydrogenase kinase 4 ameliorates kidney ischemia-reperfusion injury by reducing succinate accumulation during ischemia and preserving mitochondrial function during reperfusion.
    Oh CJ; Kim MJ; Lee JM; Kim DH; Kim IY; Park S; Kim Y; Lee KB; Lee SH; Lim CW; Kim M; Lee JY; Pagire HS; Pagire SH; Bae MA; Chanda D; Thoudam T; Khang AR; Harris RA; Ahn JH; Jeon JH; Lee IK
    Kidney Int; 2023 Oct; 104(4):724-739. PubMed ID: 37399974
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Accumulation of Succinate in Cardiac Ischemia Primarily Occurs via Canonical Krebs Cycle Activity.
    Zhang J; Wang YT; Miller JH; Day MM; Munger JC; Brookes PS
    Cell Rep; 2018 May; 23(9):2617-2628. PubMed ID: 29847793
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Ischemic defects in the electron transport chain increase the production of reactive oxygen species from isolated rat heart mitochondria.
    Chen Q; Moghaddas S; Hoppel CL; Lesnefsky EJ
    Am J Physiol Cell Physiol; 2008 Feb; 294(2):C460-6. PubMed ID: 18077608
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The role of succinate and ROS in reperfusion injury - A critical appraisal.
    Andrienko TN; Pasdois P; Pereira GC; Ovens MJ; Halestrap AP
    J Mol Cell Cardiol; 2017 Sep; 110():1-14. PubMed ID: 28689004
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Ester Prodrugs of Malonate with Enhanced Intracellular Delivery Protect Against Cardiac Ischemia-Reperfusion Injury In Vivo.
    Prag HA; Pala L; Kula-Alwar D; Mulvey JF; Luping D; Beach TE; Booty LM; Hall AR; Logan A; Sauchanka V; Caldwell ST; Robb EL; James AM; Xu Z; Saeb-Parsy K; Hartley RC; Murphy MP; Krieg T
    Cardiovasc Drugs Ther; 2022 Feb; 36(1):1-13. PubMed ID: 32648168
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Succinate accumulation drives ischaemia-reperfusion injury during organ transplantation.
    Martin JL; Costa ASH; Gruszczyk AV; Beach TE; Allen FM; Prag HA; Hinchy EC; Mahbubani K; Hamed M; Tronci L; Nikitopoulou E; James AM; Krieg T; Robinson AJ; Huang MM; Caldwell ST; Logan A; Pala L; Hartley RC; Frezza C; Saeb-Parsy K; Murphy MP
    Nat Metab; 2019 Sep; 1():966-974. PubMed ID: 32395697
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Exogenous nicotinamide adenine dinucleotide administration alleviates ischemia/reperfusion-induced oxidative injury in isolated rat hearts via Sirt5-SDH-succinate pathway.
    Liu L; Wang Q; Zhao B; Wu Q; Wang P
    Eur J Pharmacol; 2019 Sep; 858():172520. PubMed ID: 31278893
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Succinate accumulation induces mitochondrial reactive oxygen species generation and promotes status epilepticus in the kainic acid rat model.
    Zhang Y; Zhang M; Zhu W; Yu J; Wang Q; Zhang J; Cui Y; Pan X; Gao X; Sun H
    Redox Biol; 2020 Jan; 28():101365. PubMed ID: 31707354
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Cardioprotective effects of idebenone do not involve ROS scavenging: Evidence for mitochondrial complex I bypass in ischemia/reperfusion injury.
    Perry JB; Davis GN; Allen ME; Makrecka-Kuka M; Dambrova M; Grange RW; Shaikh SR; Brown DA
    J Mol Cell Cardiol; 2019 Oct; 135():160-171. PubMed ID: 31445917
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Understanding and preventing mitochondrial oxidative damage.
    Murphy MP
    Biochem Soc Trans; 2016 Oct; 44(5):1219-1226. PubMed ID: 27911703
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Mitochondrial metabolism and bioenergetic function in an anoxic isolated adult mouse cardiomyocyte model of in vivo cardiac ischemia-reperfusion injury.
    Gruszczyk AV; Casey AM; James AM; Prag HA; Burger N; Bates GR; Hall AR; Allen FM; Krieg T; Saeb-Parsy K; Murphy MP
    Redox Biol; 2022 Aug; 54():102368. PubMed ID: 35749842
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 102.