BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

203 related articles for article (PubMed ID: 25387827)

  • 1. Expression of MTAP inhibits tumor-related phenotypes in HT1080 cells via a mechanism unrelated to its enzymatic function.
    Tang B; Kadariya Y; Chen Y; Slifker M; Kruger WD
    G3 (Bethesda); 2014 Nov; 5(1):35-44. PubMed ID: 25387827
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Methylthioadenosine phosphorylase, a gene frequently codeleted with p16(cdkN2a/ARF), acts as a tumor suppressor in a breast cancer cell line.
    Christopher SA; Diegelman P; Porter CW; Kruger WD
    Cancer Res; 2002 Nov; 62(22):6639-44. PubMed ID: 12438261
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Loss of methylthioadenosine phosphorylase and elevated ornithine decarboxylase is common in pancreatic cancer.
    Subhi AL; Tang B; Balsara BR; Altomare DA; Testa JR; Cooper HS; Hoffman JP; Meropol NJ; Kruger WD
    Clin Cancer Res; 2004 Nov; 10(21):7290-6. PubMed ID: 15534104
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Methylthioadenosine phosphorylase regulates ornithine decarboxylase by production of downstream metabolites.
    Subhi AL; Diegelman P; Porter CW; Tang B; Lu ZJ; Markham GD; Kruger WD
    J Biol Chem; 2003 Dec; 278(50):49868-73. PubMed ID: 14506228
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Loss of 5'-Methylthioadenosine Phosphorylase (MTAP) is Frequent in High-Grade Gliomas; Nevertheless, it is Not Associated with Higher Tumor Aggressiveness.
    Menezes WP; Silva VAO; Gomes INF; Rosa MN; Spina MLC; Carloni AC; Alves ALV; Melendez M; Almeida GC; Silva LSD; Clara C; da Cunha IW; Hajj GNM; Jones C; Bidinotto LT; Reis RM
    Cells; 2020 Feb; 9(2):. PubMed ID: 32093414
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5.
    Mavrakis KJ; McDonald ER; Schlabach MR; Billy E; Hoffman GR; deWeck A; Ruddy DA; Venkatesan K; Yu J; McAllister G; Stump M; deBeaumont R; Ho S; Yue Y; Liu Y; Yan-Neale Y; Yang G; Lin F; Yin H; Gao H; Kipp DR; Zhao S; McNamara JT; Sprague ER; Zheng B; Lin Y; Cho YS; Gu J; Crawford K; Ciccone D; Vitari AC; Lai A; Capka V; Hurov K; Porter JA; Tallarico J; Mickanin C; Lees E; Pagliarini R; Keen N; Schmelzle T; Hofmann F; Stegmeier F; Sellers WR
    Science; 2016 Mar; 351(6278):1208-13. PubMed ID: 26912361
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Expression of methylthioadenosine phosphorylase cDNA in p16-, MTAP- malignant cells: restoration of methylthioadenosine phosphorylase-dependent salvage pathways and alterations of sensitivity to inhibitors of purine de novo synthesis.
    Chen ZH; Olopade OI; Savarese TM
    Mol Pharmacol; 1997 Nov; 52(5):903-11. PubMed ID: 9351982
    [TBL] [Abstract][Full Text] [Related]  

  • 8. A transition state analogue of 5'-methylthioadenosine phosphorylase induces apoptosis in head and neck cancers.
    Basu I; Cordovano G; Das I; Belbin TJ; Guha C; Schramm VL
    J Biol Chem; 2007 Jul; 282(29):21477-86. PubMed ID: 17548352
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Down-regulation of methylthioadenosine phosphorylase (MTAP) induces progression of hepatocellular carcinoma via accumulation of 5'-deoxy-5'-methylthioadenosine (MTA).
    Kirovski G; Stevens AP; Czech B; Dettmer K; Weiss TS; Wild P; Hartmann A; Bosserhoff AK; Oefner PJ; Hellerbrand C
    Am J Pathol; 2011 Mar; 178(3):1145-52. PubMed ID: 21356366
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Increasing the therapeutic index of 5-fluorouracil and 6-thioguanine by targeting loss of MTAP in tumor cells.
    Tang B; Testa JR; Kruger WD
    Cancer Biol Ther; 2012 Sep; 13(11):1082-90. PubMed ID: 22825330
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Downregulation of methylthioadenosin phosphorylase by homozygous deletion in gastric carcinoma.
    Kim J; Kim MA; Min SY; Jee CD; Lee HE; Kim WH
    Genes Chromosomes Cancer; 2011 Jun; 50(6):421-33. PubMed ID: 21412930
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Extracellular 5'-methylthioadenosine inhibits intracellular symmetric dimethylarginine protein methylation of FUSE-binding proteins.
    Tang B; Lee HO; Gupta S; Wang L; Kurimchak AM; Duncan JS; Kruger WD
    J Biol Chem; 2022 Sep; 298(9):102367. PubMed ID: 35963436
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Homozygous MTAP deletion in primary human glioblastoma is not associated with elevation of methylthioadenosine.
    Barekatain Y; Ackroyd JJ; Yan VC; Khadka S; Wang L; Chen KC; Poral AH; Tran T; Georgiou DK; Arthur K; Lin YH; Satani N; Ballato ES; Behr EI; deCarvalho AC; Verhaak RGW; de Groot J; Huse JT; Asara JM; Kalluri R; Muller FL
    Nat Commun; 2021 Jul; 12(1):4228. PubMed ID: 34244484
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Gene deletion chemoselectivity: codeletion of the genes for p16(INK4), methylthioadenosine phosphorylase, and the alpha- and beta-interferons in human pancreatic cell carcinoma lines and its implications for chemotherapy.
    Chen ZH; Zhang H; Savarese TM
    Cancer Res; 1996 Mar; 56(5):1083-90. PubMed ID: 8640765
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Downregulation of MTAP promotes Tumor Growth and Metastasis by regulating ODC Activity in Breast Cancer.
    Zhang Y; Zhang TT; Gao L; Tan YN; Li YT; Tan XY; Huang TX; Li HH; Bai F; Zou C; Pei XH; Tan BB; Fu L
    Int J Biol Sci; 2022; 18(7):3034-3047. PubMed ID: 35541910
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Methylthioadenosine phosphorylase gene deletions are common in osteosarcoma.
    GarcĂ­a-Castellano JM; Villanueva A; Healey JH; Sowers R; Cordon-Cardo C; Huvos A; Bertino JR; Meyers P; Gorlick R
    Clin Cancer Res; 2002 Mar; 8(3):782-7. PubMed ID: 11895909
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Specific Targeting of
    Tang B; Lee HO; An SS; Cai KQ; Kruger WD
    Cancer Res; 2018 Aug; 78(15):4386-4395. PubMed ID: 29844120
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Methylthioadenosine phosphorylase cDNA transfection alters sensitivity to depletion of purine and methionine in A549 lung cancer cells.
    Hori H; Tran P; Carrera CJ; Hori Y; Rosenbach MD; Carson DA; Nobori T
    Cancer Res; 1996 Dec; 56(24):5653-8. PubMed ID: 8971171
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Downregulated MTAP expression in myxofibrosarcoma: A characterization of inactivating mechanisms, tumor suppressive function, and therapeutic relevance.
    Li CF; Fang FM; Kung HJ; Chen LT; Wang JW; Tsai JW; Yu SC; Wang YH; Li SH; Huang HY
    Oncotarget; 2014 Nov; 5(22):11428-41. PubMed ID: 25426549
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Homozygous deletions of methylthioadenosine phosphorylase in human biliary tract cancers.
    Karikari CA; Mullendore M; Eshleman JR; Argani P; Leoni LM; Chattopadhyay S; Hidalgo M; Maitra A
    Mol Cancer Ther; 2005 Dec; 4(12):1860-6. PubMed ID: 16373701
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.