BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

202 related articles for article (PubMed ID: 25395669)

  • 1. Genetic interaction implicates iRhom2 in the regulation of EGF receptor signalling in mice.
    Siggs OM; Grieve A; Xu H; Bambrough P; Christova Y; Freeman M
    Biol Open; 2014 Nov; 3(12):1151-7. PubMed ID: 25395669
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Analysis of the function of ADAM17 in iRhom2 curly-bare and tylosis with esophageal cancer mutant mice.
    Rabinowitsch AI; Maretzky T; Weskamp G; Haxaire C; Tueshaus J; Lichtenthaler SF; Monette S; Blobel CP
    J Cell Sci; 2023 Jul; 136(13):. PubMed ID: 37282854
    [TBL] [Abstract][Full Text] [Related]  

  • 3. ADAM17 is essential for ectodomain shedding of the EGF-receptor ligand amphiregulin.
    Hosur V; Farley ML; Burzenski LM; Shultz LD; Wiles MV
    FEBS Open Bio; 2018 Apr; 8(4):702-710. PubMed ID: 29632822
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Rhbdf2 mutations increase its protein stability and drive EGFR hyperactivation through enhanced secretion of amphiregulin.
    Hosur V; Johnson KR; Burzenski LM; Stearns TM; Maser RS; Shultz LD
    Proc Natl Acad Sci U S A; 2014 May; 111(21):E2200-9. PubMed ID: 24825892
    [TBL] [Abstract][Full Text] [Related]  

  • 5. iRhom2: An Emerging Adaptor Regulating Immunity and Disease.
    Al-Salihi MA; Lang PA
    Int J Mol Sci; 2020 Sep; 21(18):. PubMed ID: 32911849
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Phosphorylation of iRhom2 at the plasma membrane controls mammalian TACE-dependent inflammatory and growth factor signalling.
    Grieve AG; Xu H; Künzel U; Bambrough P; Sieber B; Freeman M
    Elife; 2017 Apr; 6():. PubMed ID: 28432785
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Pathological mutations reveal the key role of the cytosolic iRhom2 N-terminus for phosphorylation-independent 14-3-3 interaction and ADAM17 binding, stability, and activity.
    Bläsius K; Ludwig L; Knapp S; Flaßhove C; Sonnabend F; Keller D; Tacken N; Gao X; Kahveci-Türköz S; Grannemann C; Babendreyer A; Adrain C; Huth S; Baron JM; Ludwig A; Düsterhöft S
    Cell Mol Life Sci; 2024 Feb; 81(1):102. PubMed ID: 38409522
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Investigating isoform switching in
    Masood M; Masood MBE; Us Subah N; Shabbir M; Paracha RZ; Rafiq M
    PeerJ; 2022; 10():e14124. PubMed ID: 36452073
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Mammalian iRhoms have distinct physiological functions including an essential role in TACE regulation.
    Christova Y; Adrain C; Bambrough P; Ibrahim A; Freeman M
    EMBO Rep; 2013 Oct; 14(10):884-90. PubMed ID: 23969955
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Novel functions of inactive rhomboid proteins in immunity and disease.
    Geesala R; Issuree PD; Maretzky T
    J Leukoc Biol; 2019 Oct; 106(4):823-835. PubMed ID: 31369701
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Curly bare (cub), a new mouse mutation on chromosome 11 causing skin and hair abnormalities, and a modifier gene (mcub) on chromosome 5.
    Johnson KR; Lane PW; Cook SA; Harris BS; Ward-Bailey PF; Bronson RT; Lyons BL; Shultz LD; Davisson MT
    Genomics; 2003 Jan; 81(1):6-14. PubMed ID: 12573256
    [TBL] [Abstract][Full Text] [Related]  

  • 12. iRhom2 mutation leads to aberrant hair follicle differentiation in mice.
    Leilei Y; Bing L; Yang L; Shaoxia W; Yuan X; Dongping W; Huahu Y; Shichen S; Guangzhou Z; Ruiyun P; Lin Z; Wenlong L
    PLoS One; 2014; 9(12):e115114. PubMed ID: 25546423
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structural modeling defines transmembrane residues in ADAM17 that are crucial for Rhbdf2-ADAM17-dependent proteolysis.
    Li X; Maretzky T; Perez-Aguilar JM; Monette S; Weskamp G; Le Gall S; Beutler B; Weinstein H; Blobel CP
    J Cell Sci; 2017 Mar; 130(5):868-878. PubMed ID: 28104813
    [TBL] [Abstract][Full Text] [Related]  

  • 14. iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE.
    Oikonomidi I; Burbridge E; Cavadas M; Sullivan G; Collis B; Naegele H; Clancy D; Brezinova J; Hu T; Bileck A; Gerner C; Bolado A; von Kriegsheim A; Martin SJ; Steinberg F; Strisovsky K; Adrain C
    Elife; 2018 Jun; 7():. PubMed ID: 29897333
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The Role of iRhom2 in Metabolic and Cardiovascular-Related Disorders.
    Geesala R; Issuree PD; Maretzky T
    Front Cardiovasc Med; 2020; 7():612808. PubMed ID: 33330676
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The iRhom homology domain is indispensable for ADAM17-mediated TNFα and EGF receptor ligand release.
    Düsterhöft S; Kahveci-Türköz S; Wozniak J; Seifert A; Kasparek P; Ohm H; Liu S; Kopkanova J; Lokau J; Garbers C; Preisinger C; Sedlacek R; Freeman M; Ludwig A
    Cell Mol Life Sci; 2021 Jun; 78(11):5015-5040. PubMed ID: 33950315
    [TBL] [Abstract][Full Text] [Related]  

  • 17. iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling.
    Li X; Maretzky T; Weskamp G; Monette S; Qing X; Issuree PD; Crawford HC; McIlwain DR; Mak TW; Salmon JE; Blobel CP
    Proc Natl Acad Sci U S A; 2015 May; 112(19):6080-5. PubMed ID: 25918388
    [TBL] [Abstract][Full Text] [Related]  

  • 18. iRhoms; Its Functions and Essential Roles.
    Lee MY; Nam KH; Choi KC
    Biomol Ther (Seoul); 2016 Mar; 24(2):109-14. PubMed ID: 26869525
    [TBL] [Abstract][Full Text] [Related]  

  • 19. ADAM17 stabilizes its interacting partner inactive Rhomboid 2 (iRhom2) but not inactive Rhomboid 1 (iRhom1).
    Weskamp G; Tüshaus J; Li D; Feederle R; Maretzky T; Swendemann S; Falck-Pedersen E; McIlwain DR; Mak TW; Salmon JE; Lichtenthaler SF; Blobel CP
    J Biol Chem; 2020 Mar; 295(13):4350-4358. PubMed ID: 32060096
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Cryo-EM reveals that iRhom2 restrains ADAM17 protease activity to control the release of growth factor and inflammatory signals.
    Lu F; Zhao H; Dai Y; Wang Y; Lee CH; Freeman M
    Mol Cell; 2024 May; ():. PubMed ID: 38781971
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.