BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

177 related articles for article (PubMed ID: 25399645)

  • 1. FLiK: a direct-binding assay for the identification and kinetic characterization of stabilizers of inactive kinase conformations.
    Simard JR; Rauh D
    Methods Enzymol; 2014; 548():147-71. PubMed ID: 25399645
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Fluorescence labels in kinases: a high-throughput kinase binding assay for the identification of DFG-out binding ligands.
    Simard JR; Rauh D
    Methods Mol Biol; 2012; 800():95-117. PubMed ID: 21964785
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Development of a fluorescent-tagged kinase assay system for the detection and characterization of allosteric kinase inhibitors.
    Simard JR; Getlik M; Grütter C; Pawar V; Wulfert S; Rabiller M; Rauh D
    J Am Chem Soc; 2009 Sep; 131(37):13286-96. PubMed ID: 19572644
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Discovery and characterization of non-ATP site inhibitors of the mitogen activated protein (MAP) kinases.
    Comess KM; Sun C; Abad-Zapatero C; Goedken ER; Gum RJ; Borhani DW; Argiriadi M; Groebe DR; Jia Y; Clampit JE; Haasch DL; Smith HT; Wang S; Song D; Coen ML; Cloutier TE; Tang H; Cheng X; Quinn C; Liu B; Xin Z; Liu G; Fry EH; Stoll V; Ng TI; Banach D; Marcotte D; Burns DJ; Calderwood DJ; Hajduk PJ
    ACS Chem Biol; 2011 Mar; 6(3):234-44. PubMed ID: 21090814
    [TBL] [Abstract][Full Text] [Related]  

  • 5. High-throughput screening to identify inhibitors which stabilize inactive kinase conformations in p38alpha.
    Simard JR; Grütter C; Pawar V; Aust B; Wolf A; Rabiller M; Wulfert S; Robubi A; Klüter S; Ottmann C; Rauh D
    J Am Chem Soc; 2009 Dec; 131(51):18478-88. PubMed ID: 19950957
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Sequence, structure, and active site analyses of p38 MAP kinase: exploiting DFG-out conformation as a strategy to design new type II leads.
    Badrinarayan P; Sastry GN
    J Chem Inf Model; 2011 Jan; 51(1):115-29. PubMed ID: 21141877
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Displacement assay for the detection of stabilizers of inactive kinase conformations.
    Klüter S; Grütter C; Naqvi T; Rabiller M; Simard JR; Pawar V; Getlik M; Rauh D
    J Med Chem; 2010 Jan; 53(1):357-67. PubMed ID: 19928858
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Virtual screening filters for the design of type II p38 MAP kinase inhibitors: a fragment based library generation approach.
    Badrinarayan P; Sastry GN
    J Mol Graph Model; 2012 Apr; 34():89-100. PubMed ID: 22306417
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Fluorophore labeling of the glycine-rich loop as a method of identifying inhibitors that bind to active and inactive kinase conformations.
    Simard JR; Getlik M; Grütter C; Schneider R; Wulfert S; Rauh D
    J Am Chem Soc; 2010 Mar; 132(12):4152-60. PubMed ID: 20201574
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Discovery of inter-domain stabilizers-a novel assay system for allosteric akt inhibitors.
    Fang Z; Simard JR; Plenker D; Nguyen HD; Phan T; Wolle P; Baumeister S; Rauh D
    ACS Chem Biol; 2015 Jan; 10(1):279-88. PubMed ID: 24959717
    [TBL] [Abstract][Full Text] [Related]  

  • 11. TAK1 inhibition in the DFG-out conformation.
    Kilty I; Green MP; Bell AS; Brown DG; Dodd PG; Hewson C; Hughes SJ; Phillips C; Ryckmans T; Smith RT; van Hoorn WP; Cohen P; Jones LH
    Chem Biol Drug Des; 2013 Nov; 82(5):500-5. PubMed ID: 23745990
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Identification of a New Inhibitor That Stabilizes Interleukin-2-Inducible T-Cell Kinase in Its Inactive Conformation.
    Hantani R; Hanawa S; Oie S; Umetani K; Sato T; Hantani Y
    SLAS Discov; 2019 Sep; 24(8):854-862. PubMed ID: 31247148
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Development and applications of a broad-coverage, TR-FRET-based kinase binding assay platform.
    Lebakken CS; Riddle SM; Singh U; Frazee WJ; Eliason HC; Gao Y; Reichling LJ; Marks BD; Vogel KW
    J Biomol Screen; 2009 Sep; 14(8):924-35. PubMed ID: 19564447
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Discovery of novel TAOK2 inhibitor scaffolds from high-throughput screening.
    Piala AT; Akella R; Potts MB; Dudics-Giagnocavo SA; He H; Wei S; White MA; Posner BA; Goldsmith EJ
    Bioorg Med Chem Lett; 2016 Aug; 26(16):3923-7. PubMed ID: 27426302
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Ligand efficiency based approach for efficient virtual screening of compound libraries.
    Ke YY; Coumar MS; Shiao HY; Wang WC; Chen CW; Song JS; Chen CH; Lin WH; Wu SH; Hsu JT; Chang CM; Hsieh HP
    Eur J Med Chem; 2014 Aug; 83():226-35. PubMed ID: 24960626
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Novel lead structures for p38 MAP kinase via FieldScreen virtual screening.
    Cheeseright TJ; Holm M; Lehmann F; Luik S; Göttert M; Melville JL; Laufer S
    J Med Chem; 2009 Jul; 52(14):4200-9. PubMed ID: 19489590
    [TBL] [Abstract][Full Text] [Related]  

  • 17. A high-throughput, nonisotopic, competitive binding assay for kinases using nonselective inhibitor probes (ED-NSIP).
    Vainshtein I; Silveria S; Kaul P; Rouhani R; Eglen RM; Wang J
    J Biomol Screen; 2002 Dec; 7(6):507-14. PubMed ID: 14599348
    [TBL] [Abstract][Full Text] [Related]  

  • 18. A p38 mitogen-activated protein kinase inhibitor screening method using growth recovery of Escherichia coli as an index.
    Kawai K; Saito A; Sudo T; Osada H
    Anal Biochem; 2009 May; 388(1):128-33. PubMed ID: 19248755
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.
    Gao Y; Davies SP; Augustin M; Woodward A; Patel UA; Kovelman R; Harvey KJ
    Biochem J; 2013 Apr; 451(2):313-28. PubMed ID: 23398362
    [TBL] [Abstract][Full Text] [Related]  

  • 20. A fluorescence lifetime based binding assay to characterize kinase inhibitors.
    Lebakken CS; Hee Chol Kang ; Vogel KW
    J Biomol Screen; 2007 Sep; 12(6):828-41. PubMed ID: 17644772
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.