BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

177 related articles for article (PubMed ID: 25399645)

  • 21. Detection of allosteric kinase inhibitors by displacement of active site probes.
    Lebakken CS; Reichling LJ; Ellefson JM; Riddle SM
    J Biomol Screen; 2012 Jul; 17(6):813-21. PubMed ID: 22453235
    [TBL] [Abstract][Full Text] [Related]  

  • 22. The synergy between combinatorial chemistry and high-throughput screening.
    Diller DJ
    Curr Opin Drug Discov Devel; 2008 May; 11(3):346-55. PubMed ID: 18428088
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Interaction profiles of protein kinase-inhibitor complexes and their application to virtual screening.
    Chuaqui C; Deng Z; Singh J
    J Med Chem; 2005 Jan; 48(1):121-33. PubMed ID: 15634006
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Biosensor-based approach to the identification of protein kinase ligands with dual-site modes of action.
    Navratilova I; Macdonald G; Robinson C; Hughes S; Mathias J; Phillips C; Cook A
    J Biomol Screen; 2012 Feb; 17(2):183-93. PubMed ID: 22068706
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Role of Molecular Interactions and Protein Rearrangement in the Dissociation Kinetics of p38α MAP Kinase Type-I/II/III Inhibitors.
    You W; Chang CA
    J Chem Inf Model; 2018 May; 58(5):968-981. PubMed ID: 29620886
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Global kinase screening. Applications of frontal affinity chromatography coupled to mass spectrometry in drug discovery.
    Slon-Usakiewicz JJ; Dai JR; Ng W; Foster JE; Deretey E; Toledo-Sherman L; Redden PR; Pasternak A; Reid N
    Anal Chem; 2005 Mar; 77(5):1268-74. PubMed ID: 15732906
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Allosteric Effect of Adenosine Triphosphate on Peptide Recognition by 3'5'-Cyclic Adenosine Monophosphate Dependent Protein Kinase Catalytic Subunits.
    Kivi R; Solovjova K; Haljasorg T; Arukuusk P; Järv J
    Protein J; 2016 Dec; 35(6):459-466. PubMed ID: 27848106
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Kinase crystal identification and ATP-competitive inhibitor screening using the fluorescent ligand SKF86002.
    Parker LJ; Taruya S; Tsuganezawa K; Ogawa N; Mikuni J; Honda K; Tomabechi Y; Handa N; Shirouzu M; Yokoyama S; Tanaka A
    Acta Crystallogr D Biol Crystallogr; 2014 Feb; 70(Pt 2):392-404. PubMed ID: 24531473
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Fluorescence polarization binding assay to develop inhibitors of inactive p38alpha mitogen-activated protein kinase.
    Munoz L; Selig R; Yeung YT; Peifer C; Hauser D; Laufer S
    Anal Biochem; 2010 Jun; 401(1):125-33. PubMed ID: 20175985
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Biphenyl amide p38 kinase inhibitors 1: Discovery and binding mode.
    Angell RM; Bamborough P; Cleasby A; Cockerill SG; Jones KL; Mooney CJ; Somers DO; Walker AL
    Bioorg Med Chem Lett; 2008 Jan; 18(1):318-23. PubMed ID: 18006306
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Universal and Quantitative Method To Evaluate Inhibitor Potency for Cysteinome Proteins Using a Nonspecific Activity-Based Protein Profiling Probe.
    Sameshima T; Tanaka Y; Miyahisa I
    Biochemistry; 2017 Jun; 56(23):2921-2927. PubMed ID: 28520393
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Discovery of allosteric BCR-ABL inhibitors from phenotypic screen to clinical candidate.
    Gray NS; Fabbro D
    Methods Enzymol; 2014; 548():173-88. PubMed ID: 25399646
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Discovery and Characterization of a Biologically Active Non-ATP-Competitive p38 MAP Kinase Inhibitor.
    Wilson BA; Alam MS; Guszczynski T; Jakob M; Shenoy SR; Mitchell CA; Goncharova EI; Evans JR; Wipf P; Liu G; Ashwell JD; O'Keefe BR
    J Biomol Screen; 2016 Mar; 21(3):277-89. PubMed ID: 26538432
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Residence time and kinetic efficiency analysis of extracellular signal-regulated kinase 2 inhibitors.
    Vanderpool D; Grimshaw CE; Lawson JD; Ermolieff J
    Anal Biochem; 2015 Mar; 473():46-52. PubMed ID: 25535956
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Rapid identification of ligand-binding sites by using an assignment-free NMR approach.
    Kodama Y; Takeuchi K; Shimba N; Ishikawa K; Suzuki E; Shimada I; Takahashi H
    J Med Chem; 2013 Nov; 56(22):9342-50. PubMed ID: 24171460
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Discovery of tyrosine kinase inhibitors by docking into an inactive kinase conformation generated by molecular dynamics.
    Zhao H; Huang D; Caflisch A
    ChemMedChem; 2012 Nov; 7(11):1983-90. PubMed ID: 22976951
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Computational sampling of a cryptic drug binding site in a protein receptor: explicit solvent molecular dynamics and inhibitor docking to p38 MAP kinase.
    Frembgen-Kesner T; Elcock AH
    J Mol Biol; 2006 May; 359(1):202-14. PubMed ID: 16616932
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Fragment-based approaches to the discovery of kinase inhibitors.
    Mortenson PN; Berdini V; O'Reilly M
    Methods Enzymol; 2014; 548():69-92. PubMed ID: 25399642
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Conformational analysis of the DFG-out kinase motif and biochemical profiling of structurally validated type II inhibitors.
    Vijayan RS; He P; Modi V; Duong-Ly KC; Ma H; Peterson JR; Dunbrack RL; Levy RM
    J Med Chem; 2015 Jan; 58(1):466-79. PubMed ID: 25478866
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Novel inhibitor discovery through virtual screening against multiple protein conformations generated via ligand-directed modeling: a maternal embryonic leucine zipper kinase example.
    Mahasenan KV; Li C
    J Chem Inf Model; 2012 May; 52(5):1345-55. PubMed ID: 22540736
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 9.