196 related articles for article (PubMed ID: 25418171)
1. The shapes of Z-α1-antitrypsin polymers in solution support the C-terminal domain-swap mechanism of polymerization.
Behrens MA; Sendall TJ; Pedersen JS; Kjeldgaard M; Huntington JA; Jensen JK
Biophys J; 2014 Oct; 107(8):1905-1912. PubMed ID: 25418171
[TBL] [Abstract][Full Text] [Related]
2. Molecular basis of α1-antitrypsin deficiency revealed by the structure of a domain-swapped trimer.
Yamasaki M; Sendall TJ; Pearce MC; Whisstock JC; Huntington JA
EMBO Rep; 2011 Sep; 12(10):1011-7. PubMed ID: 21909074
[TBL] [Abstract][Full Text] [Related]
3. The Z mutation alters the global structural dynamics of α1-antitrypsin.
Hughes VA; Meklemburg R; Bottomley SP; Wintrode PL
PLoS One; 2014; 9(9):e102617. PubMed ID: 25181470
[TBL] [Abstract][Full Text] [Related]
4. Discovery of an inhibitor of Z-alpha1 antitrypsin polymerization.
Berthelier V; Harris JB; Estenson KN; Baudry J
PLoS One; 2015; 10(5):e0126256. PubMed ID: 25961288
[TBL] [Abstract][Full Text] [Related]
5. Small molecules block the polymerization of Z alpha1-antitrypsin and increase the clearance of intracellular aggregates.
Mallya M; Phillips RL; Saldanha SA; Gooptu B; Brown SC; Termine DJ; Shirvani AM; Wu Y; Sifers RN; Abagyan R; Lomas DA
J Med Chem; 2007 Nov; 50(22):5357-63. PubMed ID: 17918823
[TBL] [Abstract][Full Text] [Related]
6. Molecular Mechanism of Z α1-Antitrypsin Deficiency.
Huang X; Zheng Y; Zhang F; Wei Z; Wang Y; Carrell RW; Read RJ; Chen GQ; Zhou A
J Biol Chem; 2016 Jul; 291(30):15674-86. PubMed ID: 27246852
[TBL] [Abstract][Full Text] [Related]
7. Conformational properties of the disease-causing Z variant of α1-antitrypsin revealed by theory and experiment.
Kass I; Knaupp AS; Bottomley SP; Buckle AM
Biophys J; 2012 Jun; 102(12):2856-65. PubMed ID: 22735536
[TBL] [Abstract][Full Text] [Related]
8. Aggregation of M3 (E376D) variant of alpha1- antitrypsin.
Bashir A; Hazari Y; Pal D; Maity D; Bashir S; Singh LR; Shah NN; Fazili KM
Sci Rep; 2020 May; 10(1):8290. PubMed ID: 32427833
[TBL] [Abstract][Full Text] [Related]
9. Histone deacetylase inhibitor (HDACi) suberoylanilide hydroxamic acid (SAHA)-mediated correction of α1-antitrypsin deficiency.
Bouchecareilh M; Hutt DM; Szajner P; Flotte TR; Balch WE
J Biol Chem; 2012 Nov; 287(45):38265-78. PubMed ID: 22995909
[TBL] [Abstract][Full Text] [Related]
10. Identification of a 4-mer peptide inhibitor that effectively blocks the polymerization of pathogenic Z alpha1-antitrypsin.
Chang YP; Mahadeva R; Chang WS; Shukla A; Dafforn TR; Chu YH
Am J Respir Cell Mol Biol; 2006 Nov; 35(5):540-8. PubMed ID: 16778151
[TBL] [Abstract][Full Text] [Related]
11. Loop-sheet polymerization: the mechanism of alpha1-antitrypsin deficiency.
Lomas DA
Respir Med; 2000 Aug; 94 Suppl C():S3-6. PubMed ID: 10954247
[TBL] [Abstract][Full Text] [Related]
12. Defining the mechanism of polymerization in the serpinopathies.
Ekeowa UI; Freeke J; Miranda E; Gooptu B; Bush MF; Pérez J; Teckman J; Robinson CV; Lomas DA
Proc Natl Acad Sci U S A; 2010 Oct; 107(40):17146-51. PubMed ID: 20855577
[TBL] [Abstract][Full Text] [Related]
13. Inhibition of intracellular degradation increases secretion of a mutant form of alpha1-antitrypsin associated with profound deficiency.
Novoradovskaya N; Lee J; Yu ZX; Ferrans VJ; Brantly M
J Clin Invest; 1998 Jun; 101(12):2693-701. PubMed ID: 9637703
[TBL] [Abstract][Full Text] [Related]
14. A single-chain variable fragment intrabody prevents intracellular polymerization of Z α1-antitrypsin while allowing its antiproteinase activity.
Ordóñez A; Pérez J; Tan L; Dickens JA; Motamedi-Shad N; Irving JA; Haq I; Ekeowa U; Marciniak SJ; Miranda E; Lomas DA
FASEB J; 2015 Jun; 29(6):2667-78. PubMed ID: 25757566
[TBL] [Abstract][Full Text] [Related]
15. Alpha(1)-antitrypsin deficiency, liver disease and emphysema.
Parfrey H; Mahadeva R; Lomas DA
Int J Biochem Cell Biol; 2003 Jul; 35(7):1009-14. PubMed ID: 12672469
[TBL] [Abstract][Full Text] [Related]
16. Three new alpha1-antitrypsin deficiency variants help to define a C-terminal region regulating conformational change and polymerization.
Fra AM; Gooptu B; Ferrarotti I; Miranda E; Scabini R; Ronzoni R; Benini F; Corda L; Medicina D; Luisetti M; Schiaffonati L
PLoS One; 2012; 7(6):e38405. PubMed ID: 22723858
[TBL] [Abstract][Full Text] [Related]
17. Differential detection of PAS-positive inclusions formed by the Z, Siiyama, and Mmalton variants of alpha1-antitrypsin.
Janciauskiene S; Eriksson S; Callea F; Mallya M; Zhou A; Seyama K; Hata S; Lomas DA
Hepatology; 2004 Nov; 40(5):1203-10. PubMed ID: 15486938
[TBL] [Abstract][Full Text] [Related]
18. Lung polymers in Z alpha1-antitrypsin deficiency-related emphysema.
Elliott PR; Bilton D; Lomas DA
Am J Respir Cell Mol Biol; 1998 May; 18(5):670-4. PubMed ID: 9569237
[TBL] [Abstract][Full Text] [Related]
19. A novel monoclonal antibody to characterize pathogenic polymers in liver disease associated with alpha1-antitrypsin deficiency.
Miranda E; Pérez J; Ekeowa UI; Hadzic N; Kalsheker N; Gooptu B; Portmann B; Belorgey D; Hill M; Chambers S; Teckman J; Alexander GJ; Marciniak SJ; Lomas DA
Hepatology; 2010 Sep; 52(3):1078-88. PubMed ID: 20583215
[TBL] [Abstract][Full Text] [Related]
20. Polymers of Z alpha1-antitrypsin co-localize with neutrophils in emphysematous alveoli and are chemotactic in vivo.
Mahadeva R; Atkinson C; Li Z; Stewart S; Janciauskiene S; Kelley DG; Parmar J; Pitman R; Shapiro SD; Lomas DA
Am J Pathol; 2005 Feb; 166(2):377-86. PubMed ID: 15681822
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]