These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

238 related articles for article (PubMed ID: 25420019)

  • 1. Role of Ca2+ and L-Phe in regulating functional cooperativity of disease-associated "toggle" calcium-sensing receptor mutations.
    Zhang C; Mulpuri N; Hannan FM; Nesbit MA; Thakker RV; Hamelberg D; Brown EM; Yang JJ
    PLoS One; 2014; 9(11):e113622. PubMed ID: 25420019
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Identification of 70 calcium-sensing receptor mutations in hyper- and hypo-calcaemic patients: evidence for clustering of extracellular domain mutations at calcium-binding sites.
    Hannan FM; Nesbit MA; Zhang C; Cranston T; Curley AJ; Harding B; Fratter C; Rust N; Christie PT; Turner JJ; Lemos MC; Bowl MR; Bouillon R; Brain C; Bridges N; Burren C; Connell JM; Jung H; Marks E; McCredie D; Mughal Z; Rodda C; Tollefsen S; Brown EM; Yang JJ; Thakker RV
    Hum Mol Genet; 2012 Jun; 21(12):2768-78. PubMed ID: 22422767
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Identification of an L-phenylalanine binding site enhancing the cooperative responses of the calcium-sensing receptor to calcium.
    Zhang C; Huang Y; Jiang Y; Mulpuri N; Wei L; Hamelberg D; Brown EM; Yang JJ
    J Biol Chem; 2014 Feb; 289(8):5296-309. PubMed ID: 24394414
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Intracellular Ca(2+) oscillations generated via the extracellular Ca(2+)-sensing receptor (CaSR) in response to extracellular Ca(2+) or L-phenylalanine: Impact of the highly conservative mutation Ser170Thr.
    Young SH; Rey O; Rozengurt E
    Biochem Biophys Res Commun; 2015 Nov; 467(1):1-6. PubMed ID: 26431875
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Allosteric Modulation of the Calcium-sensing Receptor Rectifies Signaling Abnormalities Associated with G-protein α-11 Mutations Causing Hypercalcemic and Hypocalcemic Disorders.
    Babinsky VN; Hannan FM; Gorvin CM; Howles SA; Nesbit MA; Rust N; Hanyaloglu AC; Hu J; Spiegel AM; Thakker RV
    J Biol Chem; 2016 May; 291(20):10876-85. PubMed ID: 26994139
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Delineating a Ca2+ binding pocket within the venus flytrap module of the human calcium-sensing receptor.
    Silve C; Petrel C; Leroy C; Bruel H; Mallet E; Rognan D; Ruat M
    J Biol Chem; 2005 Nov; 280(45):37917-23. PubMed ID: 16147994
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Impact of clinically relevant mutations on the pharmacoregulation and signaling bias of the calcium-sensing receptor by positive and negative allosteric modulators.
    Leach K; Wen A; Cook AE; Sexton PM; Conigrave AD; Christopoulos A
    Endocrinology; 2013 Mar; 154(3):1105-16. PubMed ID: 23372019
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Structural mechanism of cooperative activation of the human calcium-sensing receptor by Ca
    Ling S; Shi P; Liu S; Meng X; Zhou Y; Sun W; Chang S; Zhang X; Zhang L; Shi C; Sun D; Liu L; Tian C
    Cell Res; 2021 Apr; 31(4):383-394. PubMed ID: 33603117
    [TBL] [Abstract][Full Text] [Related]  

  • 9. A double mutation in the extracellular Ca2+-sensing receptor's venus flytrap domain that selectively disables L-amino acid sensing.
    Mun HC; Culverston EL; Franks AH; Collyer CA; Clifton-Bligh RJ; Conigrave AD
    J Biol Chem; 2005 Aug; 280(32):29067-72. PubMed ID: 15888439
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Direct determination of multiple ligand interactions with the extracellular domain of the calcium-sensing receptor.
    Zhang C; Zhuo Y; Moniz HA; Wang S; Moremen KW; Prestegard JH; Brown EM; Yang JJ
    J Biol Chem; 2014 Nov; 289(48):33529-42. PubMed ID: 25305020
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Positive and negative allosteric modulators of the Ca2+-sensing receptor interact within overlapping but not identical binding sites in the transmembrane domain.
    Petrel C; Kessler A; Dauban P; Dodd RH; Rognan D; Ruat M
    J Biol Chem; 2004 Apr; 279(18):18990-7. PubMed ID: 14976203
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Impaired cotranslational processing of the calcium-sensing receptor due to signal peptide missense mutations in familial hypocalciuric hypercalcemia.
    Pidasheva S; Canaff L; Simonds WF; Marx SJ; Hendy GN
    Hum Mol Genet; 2005 Jun; 14(12):1679-90. PubMed ID: 15879434
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Two novel mutations of the calcium-sensing receptor gene affecting the same amino acid position lead to opposite phenotypes and reveal the importance of p.N802 on receptor activity.
    Lia-Baldini AS; Magdelaine C; Nizou A; Airault C; Salles JP; Moulin P; Delemer B; Aitouares M; Funalot B; Sturtz F; Lienhardt-Roussie A
    Eur J Endocrinol; 2013 Feb; 168(2):K27-34. PubMed ID: 23169696
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Calcium-sensing receptor residues with loss- and gain-of-function mutations are located in regions of conformational change and cause signalling bias.
    Gorvin CM; Frost M; Malinauskas T; Cranston T; Boon H; Siebold C; Jones EY; Hannan FM; Thakker RV
    Hum Mol Genet; 2018 Nov; 27(21):3720-3733. PubMed ID: 30052933
    [TBL] [Abstract][Full Text] [Related]  

  • 15. A calcium-sensing receptor mutation causing hypocalcemia disrupts a transmembrane salt bridge to activate β-arrestin-biased signaling.
    Gorvin CM; Babinsky VN; Malinauskas T; Nissen PH; Schou AJ; Hanyaloglu AC; Siebold C; Jones EY; Hannan FM; Thakker RV
    Sci Signal; 2018 Feb; 11(518):. PubMed ID: 29463778
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Novel activating mutations of the calcium-sensing receptor: the calcilytic NPS-2143 mitigates excessive signal transduction of mutant receptors.
    Letz S; Rus R; Haag C; Dörr HG; Schnabel D; Möhlig M; Schulze E; Frank-Raue K; Raue F; Mayr B; Schöfl C
    J Clin Endocrinol Metab; 2010 Oct; 95(10):E229-33. PubMed ID: 20668040
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Functional evaluation of a novel nonsense variant of the calcium-sensing receptor gene leading to hypocalcemia.
    Saglia C; Arruga F; Scolari C; Kalantari S; Albanese S; Bracciamà V; Corso Faini A; Brach Del Prever G; Luca M; Romeo C; Mioli F; Migliorero M; Tessaris D; Carli D; Amoroso A; Vaisitti T; De Sanctis L; Deaglio S
    Eur J Endocrinol; 2024 Mar; 190(4):296-306. PubMed ID: 38561929
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Novel inactivating mutations of the calcium-sensing receptor: the calcimimetic NPS R-568 improves signal transduction of mutant receptors.
    Rus R; Haag C; Bumke-Vogt C; Bähr V; Mayr B; Möhlig M; Schulze E; Frank-Raue K; Raue F; Schöfl C
    J Clin Endocrinol Metab; 2008 Dec; 93(12):4797-803. PubMed ID: 18796518
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A G-protein Subunit-α11 Loss-of-Function Mutation, Thr54Met, Causes Familial Hypocalciuric Hypercalcemia Type 2 (FHH2).
    Gorvin CM; Cranston T; Hannan FM; Rust N; Qureshi A; Nesbit MA; Thakker RV
    J Bone Miner Res; 2016 Jun; 31(6):1200-6. PubMed ID: 26729423
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Naturally-occurring mutation in the calcium-sensing receptor reveals the significance of extracellular domain loop III region for class C G-protein-coupled receptor function.
    Dong Q; Cheng Z; Chang W; Blackman BE; Conte FA; Hu J; Shoback D; Miller WL
    J Clin Endocrinol Metab; 2010 Oct; 95(10):E245-52. PubMed ID: 20631026
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.