BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

174 related articles for article (PubMed ID: 25421965)

  • 1. Identification of prolyl hydroxylation modifications in mammalian cell proteins.
    Arsenault PR; Heaton-Johnson KJ; Li LS; Song D; Ferreira VS; Patel N; Master SR; Lee FS
    Proteomics; 2015 Apr; 15(7):1259-67. PubMed ID: 25421965
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Proline hydroxylation at different sites in hypoxia-inducible factor 1α modulates its interactions with the von Hippel-Lindau tumor suppressor protein.
    Qian H; Zou Y; Tang Y; Gong Y; Qian Z; Wei G; Zhang Q
    Phys Chem Chem Phys; 2018 Jul; 20(27):18756-18765. PubMed ID: 29961792
    [TBL] [Abstract][Full Text] [Related]  

  • 3. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.
    Epstein AC; Gleadle JM; McNeill LA; Hewitson KS; O'Rourke J; Mole DR; Mukherji M; Metzen E; Wilson MI; Dhanda A; Tian YM; Masson N; Hamilton DL; Jaakkola P; Barstead R; Hodgkin J; Maxwell PH; Pugh CW; Schofield CJ; Ratcliffe PJ
    Cell; 2001 Oct; 107(1):43-54. PubMed ID: 11595184
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation.
    Jaakkola P; Mole DR; Tian YM; Wilson MI; Gielbert J; Gaskell SJ; von Kriegsheim A; Hebestreit HF; Mukherji M; Schofield CJ; Maxwell PH; Pugh CW; Ratcliffe PJ
    Science; 2001 Apr; 292(5516):468-72. PubMed ID: 11292861
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Sequence determinants in hypoxia-inducible factor-1alpha for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3.
    Huang J; Zhao Q; Mooney SM; Lee FS
    J Biol Chem; 2002 Oct; 277(42):39792-800. PubMed ID: 12181324
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Leu-574 of human HIF-1alpha is a molecular determinant of prolyl hydroxylation.
    Kageyama Y; Koshiji M; To KK; Tian YM; Ratcliffe PJ; Huang LE
    FASEB J; 2004 Jun; 18(9):1028-30. PubMed ID: 15084514
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Proline Hydroxylation Primes Protein Kinases for Autophosphorylation and Activation.
    Lee SB; Ko A; Oh YT; Shi P; D'Angelo F; Frangaj B; Koller A; Chen EI; Cardozo T; Iavarone A; Lasorella A
    Mol Cell; 2020 Aug; 79(3):376-389.e8. PubMed ID: 32640193
    [TBL] [Abstract][Full Text] [Related]  

  • 8. HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation.
    Yu F; White SB; Zhao Q; Lee FS
    Proc Natl Acad Sci U S A; 2001 Aug; 98(17):9630-5. PubMed ID: 11504942
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation.
    Masson N; Willam C; Maxwell PH; Pugh CW; Ratcliffe PJ
    EMBO J; 2001 Sep; 20(18):5197-206. PubMed ID: 11566883
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Hydroxylation-Dependent Interaction of Substrates to the Von Hippel-Lindau Tumor Suppressor Protein (VHL).
    Heir P; Ohh M
    Methods Mol Biol; 2016; 1458():87-94. PubMed ID: 27581016
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha.
    Chan DA; Sutphin PD; Denko NC; Giaccia AJ
    J Biol Chem; 2002 Oct; 277(42):40112-7. PubMed ID: 12186875
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Hypoxia-inducible factor-1 (HIF-1) promotes its degradation by induction of HIF-alpha-prolyl-4-hydroxylases.
    Marxsen JH; Stengel P; Doege K; Heikkinen P; Jokilehto T; Wagner T; Jelkmann W; Jaakkola P; Metzen E
    Biochem J; 2004 Aug; 381(Pt 3):761-7. PubMed ID: 15104534
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Prolyl hydroxylation regulates protein degradation, synthesis, and splicing in human induced pluripotent stem cell-derived cardiomyocytes.
    Stoehr A; Yang Y; Patel S; Evangelista AM; Aponte A; Wang G; Liu P; Boylston J; Kloner PH; Lin Y; Gucek M; Zhu J; Murphy E
    Cardiovasc Res; 2016 Jun; 110(3):346-58. PubMed ID: 27095734
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Post-translationally abnormal collagens of prolyl 3-hydroxylase-2 null mice offer a pathobiological mechanism for the high myopia linked to human LEPREL1 mutations.
    Hudson DM; Joeng KS; Werther R; Rajagopal A; Weis M; Lee BH; Eyre DR
    J Biol Chem; 2015 Mar; 290(13):8613-22. PubMed ID: 25645914
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases.
    Chowdhury R; McDonough MA; Mecinović J; Loenarz C; Flashman E; Hewitson KS; Domene C; Schofield CJ
    Structure; 2009 Jul; 17(7):981-9. PubMed ID: 19604478
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Protein Hydroxylation by Hypoxia-Inducible Factor (HIF) Hydroxylases: Unique or Ubiquitous?
    Strowitzki MJ; Cummins EP; Taylor CT
    Cells; 2019 Apr; 8(5):. PubMed ID: 31035491
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Cone snail prolyl-4-hydroxylase α-subunit sequences derived from transcriptomic data and mass spectrometric analysis of variable proline hydroxylation in C. amadis venom.
    Vijayasarathy M; Balaram P
    J Proteomics; 2019 Mar; 194():37-48. PubMed ID: 30593932
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Coordinate regulation of the oxygen-dependent degradation domains of hypoxia-inducible factor 1 alpha.
    Chan DA; Sutphin PD; Yen SE; Giaccia AJ
    Mol Cell Biol; 2005 Aug; 25(15):6415-26. PubMed ID: 16024780
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Regulation of HIF by the von Hippel-Lindau tumour suppressor: implications for cellular oxygen sensing.
    Mole DR; Maxwell PH; Pugh CW; Ratcliffe PJ
    IUBMB Life; 2001 Jul; 52(1-2):43-7. PubMed ID: 11795592
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Hypoxia up-regulates prolyl hydroxylase activity: a feedback mechanism that limits HIF-1 responses during reoxygenation.
    D'Angelo G; Duplan E; Boyer N; Vigne P; Frelin C
    J Biol Chem; 2003 Oct; 278(40):38183-7. PubMed ID: 12876291
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.