These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

186 related articles for article (PubMed ID: 25435150)

  • 21. The pharmacologic characterization of allosteric molecules: Gq protein activation.
    Bdioui S; Verdi J; Pierre N; Trinquet E; Roux T; Kenakin T
    J Recept Signal Transduct Res; 2019 Apr; 39(2):106-113. PubMed ID: 31322035
    [No Abstract]   [Full Text] [Related]  

  • 22. Cryptic pocket formation underlies allosteric modulator selectivity at muscarinic GPCRs.
    Hollingsworth SA; Kelly B; Valant C; Michaelis JA; Mastromihalis O; Thompson G; Venkatakrishnan AJ; Hertig S; Scammells PJ; Sexton PM; Felder CC; Christopoulos A; Dror RO
    Nat Commun; 2019 Jul; 10(1):3289. PubMed ID: 31337749
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Discovery of a potential positive allosteric modulator of glucagon-like peptide 1 receptor through virtual screening and experimental study.
    Redij T; Ma J; Li Z; Hua X; Li Z
    J Comput Aided Mol Des; 2019 Nov; 33(11):973-981. PubMed ID: 31758355
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Chemical lead optimization of a pan G(q) mAChR M(1), M(3), M(5) positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M(5) PAM.
    Bridges TM; Kennedy JP; Cho HP; Breininger ML; Gentry PR; Hopkins CR; Conn PJ; Lindsley CW
    Bioorg Med Chem Lett; 2010 Jan; 20(2):558-62. PubMed ID: 20004578
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Design and optimization of selective azaindole amide M1 positive allosteric modulators.
    Davoren JE; O'Neil SV; Anderson DP; Brodney MA; Chenard L; Dlugolenski K; Edgerton JR; Green M; Garnsey M; Grimwood S; Harris AR; Kauffman GW; LaChapelle E; Lazzaro JT; Lee CW; Lotarski SM; Nason DM; Obach RS; Reinhart V; Salomon-Ferrer R; Steyn SJ; Webb D; Yan J; Zhang L
    Bioorg Med Chem Lett; 2016 Jan; 26(2):650-655. PubMed ID: 26631313
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Orthosteric and allosteric modes of interaction of novel selective agonists of the M1 muscarinic acetylcholine receptor.
    Avlani VA; Langmead CJ; Guida E; Wood MD; Tehan BG; Herdon HJ; Watson JM; Sexton PM; Christopoulos A
    Mol Pharmacol; 2010 Jul; 78(1):94-104. PubMed ID: 20413650
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Characterization of a Novel M1 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator Radioligand, [3H]PT-1284.
    Smith DL; Davoren JE; Edgerton JR; Lazzaro JT; Lee CW; Neal S; Zhang L; Grimwood S
    Mol Pharmacol; 2016 Sep; 90(3):177-87. PubMed ID: 27382013
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Discovery and optimization of a novel, selective and brain penetrant M1 positive allosteric modulator (PAM): the development of ML169, an MLPCN probe.
    Reid PR; Bridges TM; Sheffler DJ; Cho HP; Lewis LM; Days E; Daniels JS; Jones CK; Niswender CM; Weaver CD; Conn PJ; Lindsley CW; Wood MR
    Bioorg Med Chem Lett; 2011 May; 21(9):2697-701. PubMed ID: 21194936
    [TBL] [Abstract][Full Text] [Related]  

  • 29. An Approach to Discovering Novel Muscarinic M
    Kurimoto E; Matsuda S; Shimizu Y; Sako Y; Mandai T; Sugimoto T; Sakamoto H; Kimura H
    J Pharmacol Exp Ther; 2018 Jan; 364(1):28-37. PubMed ID: 29025977
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Further optimization of the M1 PAM VU0453595: Discovery of novel heterobicyclic core motifs with improved CNS penetration.
    Panarese JD; Cho HP; Adams JJ; Nance KD; Garcia-Barrantes PM; Chang S; Morrison RD; Blobaum AL; Niswender CM; Stauffer SR; Conn PJ; Lindsley CW
    Bioorg Med Chem Lett; 2016 Aug; 26(15):3822-5. PubMed ID: 27173801
    [TBL] [Abstract][Full Text] [Related]  

  • 31. 4-Phenylpyridin-2-one Derivatives: A Novel Class of Positive Allosteric Modulator of the M1 Muscarinic Acetylcholine Receptor.
    Mistry SN; Jörg M; Lim H; Vinh NB; Sexton PM; Capuano B; Christopoulos A; Lane JR; Scammells PJ
    J Med Chem; 2016 Jan; 59(1):388-409. PubMed ID: 26624844
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Development of Novel 4-Arylpyridin-2-one and 6-Arylpyrimidin-4-one Positive Allosteric Modulators of the M
    Jörg M; Khajehali E; van der Westhuizen ET; C Choy KH; Shackleford DM; Tobin AB; Sexton PM; Valant C; Capuano B; Christopoulos A; Scammells PJ
    ChemMedChem; 2021 Jan; 16(1):216-233. PubMed ID: 32851779
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Probing an Allosteric Pocket of CDK2 with Small Molecules.
    Christodoulou MS; Caporuscio F; Restelli V; Carlino L; Cannazza G; Costanzi E; Citti C; Lo Presti L; Pisani P; Battistutta R; Broggini M; Passarella D; Rastelli G
    ChemMedChem; 2017 Jan; 12(1):33-41. PubMed ID: 27860401
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Discovery and SAR of a novel series of metabotropic glutamate receptor 5 positive allosteric modulators with high ligand efficiency.
    Turlington M; Noetzel MJ; Bridges TM; Vinson PN; Steckler T; Lavreysen H; Mackie C; Bartolomé-Nebreda JM; Conde-Ceide S; Tong HM; Macdonald GJ; Daniels JS; Jones CK; Niswender CM; Conn PJ; Lindsley CW; Stauffer SR
    Bioorg Med Chem Lett; 2014 Aug; 24(15):3641-6. PubMed ID: 24961642
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Discovery of the Potent and Selective M1 PAM-Agonist N-[(3R,4S)-3-Hydroxytetrahydro-2H-pyran-4-yl]-5-methyl-4-[4-(1,3-thiazol-4-yl)benzyl]pyridine-2-carboxamide (PF-06767832): Evaluation of Efficacy and Cholinergic Side Effects.
    Davoren JE; Lee CW; Garnsey M; Brodney MA; Cordes J; Dlugolenski K; Edgerton JR; Harris AR; Helal CJ; Jenkinson S; Kauffman GW; Kenakin TP; Lazzaro JT; Lotarski SM; Mao Y; Nason DM; Northcott C; Nottebaum L; O'Neil SV; Pettersen B; Popiolek M; Reinhart V; Salomon-Ferrer R; Steyn SJ; Webb D; Zhang L; Grimwood S
    J Med Chem; 2016 Jul; 59(13):6313-28. PubMed ID: 27275946
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Homology modeling, docking, and molecular dynamics simulation of the receptor GALR2 and its interactions with galanin and a positive allosteric modulator.
    Hui WQ; Cheng Q; Liu TY; Ouyang Q
    J Mol Model; 2016 Apr; 22(4):90. PubMed ID: 27021209
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Crystal structures of the M1 and M4 muscarinic acetylcholine receptors.
    Thal DM; Sun B; Feng D; Nawaratne V; Leach K; Felder CC; Bures MG; Evans DA; Weis WI; Bachhawat P; Kobilka TS; Sexton PM; Kobilka BK; Christopoulos A
    Nature; 2016 Mar; 531(7594):335-40. PubMed ID: 26958838
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Novel Fused Arylpyrimidinone Based Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptor.
    Mistry SN; Lim H; Jörg M; Capuano B; Christopoulos A; Lane JR; Scammells PJ
    ACS Chem Neurosci; 2016 May; 7(5):647-61. PubMed ID: 26891194
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Investigation of the interaction of a putative allosteric modulator, N-(2,3-diphenyl-1,2,4-thiadiazole-5-(2H)-ylidene) methanamine hydrobromide (SCH-202676), with M1 muscarinic acetylcholine receptors.
    Lanzafame A; Christopoulos A
    J Pharmacol Exp Ther; 2004 Mar; 308(3):830-7. PubMed ID: 14617684
    [TBL] [Abstract][Full Text] [Related]  

  • 40. SAR studies on mGlu5 receptor positive allosteric modulators (2003- 2013).
    Hao J; Xiong H
    Curr Top Med Chem; 2014; 14(15):1789-841. PubMed ID: 25176124
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 10.