164 related articles for article (PubMed ID: 25438759)
1. Synthesis and evaluation of bivalent ligands for binding to the human melanocortin-4 receptor.
Fernandes SM; Lee YS; Gillies RJ; Hruby VJ
Bioorg Med Chem; 2014 Nov; 22(22):6360-5. PubMed ID: 25438759
[TBL] [Abstract][Full Text] [Related]
2. Biological and conformational examination of stereochemical modifications using the template melanotropin peptide, Ac-Nle-c[Asp-His-Phe-Arg-Trp-Ala-Lys]-NH2, on human melanocortin receptors.
Haskell-Luevano C; Nikiforovich G; Sharma SD; Yang YK; Dickinson C; Hruby VJ; Gantz I
J Med Chem; 1997 May; 40(11):1738-48. PubMed ID: 9171884
[TBL] [Abstract][Full Text] [Related]
3. Synthesis and evaluation of bivalent NDP-alpha-MSH(7) peptide ligands for binding to the human melanocortin receptor 4 (hMC4R).
Handl HL; Sankaranarayanan R; Josan JS; Vagner J; Mash EA; Gillies RJ; Hruby VJ
Bioconjug Chem; 2007; 18(4):1101-9. PubMed ID: 17591746
[TBL] [Abstract][Full Text] [Related]
4. Synthesis and characterization of time-resolved fluorescence probes for evaluation of competitive binding to melanocortin receptors.
Alleti R; Vagner J; Dehigaspitiya DC; Moberg VE; Elshan NG; Tafreshi NK; Brabez N; Weber CS; Lynch RM; Hruby VJ; Gillies RJ; Morse DL; Mash EA
Bioorg Med Chem; 2013 Sep; 21(17):5029-38. PubMed ID: 23890524
[TBL] [Abstract][Full Text] [Related]
5. Agonist-dependent internalization of the human melanocortin-4 receptors in human embryonic kidney 293 cells.
Gao Z; Lei D; Welch J; Le K; Lin J; Leng S; Duhl D
J Pharmacol Exp Ther; 2003 Dec; 307(3):870-7. PubMed ID: 14534363
[TBL] [Abstract][Full Text] [Related]
6. Structure-activity relationships of gamma-MSH analogues at the human melanocortin MC3, MC4, and MC5 receptors. Discovery of highly selective hMC3R, hMC4R, and hMC5R analogues.
Balse-Srinivasan P; Grieco P; Cai M; Trivedi D; Hruby VJ
J Med Chem; 2003 Nov; 46(23):4965-73. PubMed ID: 14584947
[TBL] [Abstract][Full Text] [Related]
7. Design of novel chimeric melanotropin-deltorphin analogues. Discovery of the first potent human melanocortin 1 receptor antagonist.
Han G; Quillan JM; Carlson K; Sadée W; Hruby VJ
J Med Chem; 2003 Feb; 46(5):810-9. PubMed ID: 12593660
[TBL] [Abstract][Full Text] [Related]
8. Identification of putative agouti-related protein(87-132)-melanocortin-4 receptor interactions by homology molecular modeling and validation using chimeric peptide ligands.
Wilczynski A; Wang XS; Joseph CG; Xiang Z; Bauzo RM; Scott JW; Sorensen NB; Shaw AM; Millard WJ; Richards NG; Haskell-Luevano C
J Med Chem; 2004 Apr; 47(9):2194-207. PubMed ID: 15084118
[TBL] [Abstract][Full Text] [Related]
9. Accelerating sensory recovery after sciatic nerve crush: non-selective versus melanocortin MC4 receptor-selective peptides.
Nijenhuis WA; Wanders N; Kruijtzer JA; Liskamp RM; Gispen WH; Adan RA
Eur J Pharmacol; 2004 Jul; 495(2-3):145-52. PubMed ID: 15249163
[TBL] [Abstract][Full Text] [Related]
10. Structure-activity relationships of the melanocortin tetrapeptide Ac-His-D-Phe-Arg-Trp-NH2 at the mouse melanocortin receptors. 4. Modifications at the Trp position.
Holder JR; Xiang Z; Bauzo RM; Haskell-Luevano C
J Med Chem; 2002 Dec; 45(26):5736-44. PubMed ID: 12477357
[TBL] [Abstract][Full Text] [Related]
11. De novo design, synthesis, and pharmacology of alpha-melanocyte stimulating hormone analogues derived from somatostatin by a hybrid approach.
Han G; Haskell-Luevano C; Kendall L; Bonner G; Hadley ME; Cone RD; Hruby VJ
J Med Chem; 2004 Mar; 47(6):1514-26. PubMed ID: 14998337
[TBL] [Abstract][Full Text] [Related]
12. Analogs of lactam derivatives of alpha-melanotropin with basic and acidic residues.
Bednarek MA; MacNeil T; Kalyani RN; Tang R; Van der Ploeg LH; Weinberg DH
Biochem Biophys Res Commun; 2000 May; 272(1):23-8. PubMed ID: 10872798
[TBL] [Abstract][Full Text] [Related]
13. A Direct in Vivo Comparison of the Melanocortin Monovalent Agonist Ac-His-DPhe-Arg-Trp-NH
Lensing CJ; Adank DN; Wilber SL; Freeman KT; Schnell SM; Speth RC; Zarth AT; Haskell-Luevano C
ACS Chem Neurosci; 2017 Jun; 8(6):1262-1278. PubMed ID: 28128928
[TBL] [Abstract][Full Text] [Related]
14. Substitution of arginine with proline and proline derivatives in melanocyte-stimulating hormones leads to selectivity for human melanocortin 4 receptor.
Qu H; Cai M; Mayorov AV; Grieco P; Zingsheim M; Trivedi D; Hruby VJ
J Med Chem; 2009 Jun; 52(12):3627-35. PubMed ID: 19473029
[TBL] [Abstract][Full Text] [Related]
15. Structure activity studies of the melanocortin antagonist SHU9119 modified at the 6, 7, 8, and 9 positions.
Haskell-Luevano C; Lim S; Yuan W; Cone RD; Hruby VJ
Peptides; 2000 Jan; 21(1):49-57. PubMed ID: 10704719
[TBL] [Abstract][Full Text] [Related]
16. Discovery of prototype peptidomimetic agonists at the human melanocortin receptors MC1R and MC4R.
Haskell-Luevano C; Hendrata S; North C; Sawyer TK; Hadley ME; Hruby VJ; Dickinson C; Gantz I
J Med Chem; 1997 Jul; 40(14):2133-9. PubMed ID: 9216831
[TBL] [Abstract][Full Text] [Related]
17. Biological and conformational study of beta-substituted prolines in MT-II template: steric effects leading to human MC5 receptor selectivity.
Cai M; Cai C; Mayorov AV; Xiong C; Cabello CM; Soloshonok VA; Swift JR; Trivedi D; Hruby VJ
J Pept Res; 2004 Feb; 63(2):116-31. PubMed ID: 15009533
[TBL] [Abstract][Full Text] [Related]
18. Systematic Backbone Conformational Constraints on a Cyclic Melanotropin Ligand Leads to Highly Selective Ligands for Multiple Melanocortin Receptors.
Cai M; Marelli UK; Bao J; Beck JG; Opperer F; Rechenmacher F; McLeod KR; Zingsheim MR; Doedens L; Kessler H; Hruby VJ
J Med Chem; 2015 Aug; 58(16):6359-67. PubMed ID: 26218460
[TBL] [Abstract][Full Text] [Related]
19. Synthesis of bivalent MSH ligands and evaluation of their binding to hMC4R using MSH lanthaligand.
Fernandes SM; Sankaranarayanan R; Xu L; Josan J; Vagner J; Gillies R; Hruby VJ
Adv Exp Med Biol; 2009; 611():433-4. PubMed ID: 19400253
[No Abstract] [Full Text] [Related]
20. Design and synthesis of highly potent and selective melanotropin analogues of SHU9119 modified at position 6.
Grieco P; Han G; Weinberg D; Van der Ploeg LH; Hruby VJ
Biochem Biophys Res Commun; 2002 Apr; 292(4):1075-80. PubMed ID: 11944925
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
