These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

146 related articles for article (PubMed ID: 25446989)

  • 21. Selective hippocampal neurodegeneration in transgenic mice expressing small amounts of truncated Aβ is induced by pyroglutamate-Aβ formation.
    Alexandru A; Jagla W; Graubner S; Becker A; Bäuscher C; Kohlmann S; Sedlmeier R; Raber KA; Cynis H; Rönicke R; Reymann KG; Petrasch-Parwez E; Hartlage-Rübsamen M; Waniek A; Rossner S; Schilling S; Osmand AP; Demuth HU; von Hörsten S
    J Neurosci; 2011 Sep; 31(36):12790-801. PubMed ID: 21900558
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Glutaminyl Cyclase Inhibitor PQ912 Improves Cognition in Mouse Models of Alzheimer's Disease-Studies on Relation to Effective Target Occupancy.
    Hoffmann T; Meyer A; Heiser U; Kurat S; Böhme L; Kleinschmidt M; Bühring KU; Hutter-Paier B; Farcher M; Demuth HU; Lues I; Schilling S
    J Pharmacol Exp Ther; 2017 Jul; 362(1):119-130. PubMed ID: 28446518
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Pyroglutamate-amyloid-β and glutaminyl cyclase are colocalized with amyloid-β in secretory vesicles and undergo activity-dependent, regulated secretion.
    Cynis H; Funkelstein L; Toneff T; Mosier C; Ziegler M; Koch B; Demuth HU; Hook V
    Neurodegener Dis; 2014; 14(2):85-97. PubMed ID: 24943989
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Amyloid-beta causes memory impairment by disturbing the JAK2/STAT3 axis in hippocampal neurons.
    Chiba T; Yamada M; Sasabe J; Terashita K; Shimoda M; Matsuoka M; Aiso S
    Mol Psychiatry; 2009 Feb; 14(2):206-22. PubMed ID: 18813209
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Glutaminyl cyclase knock-out mice exhibit slight hypothyroidism but no hypogonadism: implications for enzyme function and drug development.
    Schilling S; Kohlmann S; Bäuscher C; Sedlmeier R; Koch B; Eichentopf R; Becker A; Cynis H; Hoffmann T; Berg S; Freyse EJ; von Hörsten S; Rossner S; Graubner S; Demuth HU
    J Biol Chem; 2011 Apr; 286(16):14199-208. PubMed ID: 21330373
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Mouse strain and brain region-specific expression of the glutaminyl cyclases QC and isoQC.
    Höfling C; Indrischek H; Höpcke T; Waniek A; Cynis H; Koch B; Schilling S; Morawski M; Demuth HU; Roßner S; Hartlage-Rübsamen M
    Int J Dev Neurosci; 2014 Aug; 36():64-73. PubMed ID: 24886834
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Glutaminyl cyclases unfold glutamyl cyclase activity under mild acid conditions.
    Schilling S; Hoffmann T; Manhart S; Hoffmann M; Demuth HU
    FEBS Lett; 2004 Apr; 563(1-3):191-6. PubMed ID: 15063747
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Critical role for thyroid hormone receptor beta2 in the regulation of paraventricular thyrotropin-releasing hormone neurons.
    Abel ED; Ahima RS; Boers ME; Elmquist JK; Wondisford FE
    J Clin Invest; 2001 Apr; 107(8):1017-23. PubMed ID: 11306605
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Human glutaminyl cyclase: Structure, function, inhibitors and involvement in Alzheimer's disease.
    Vijayan DK; Zhang KYJ
    Pharmacol Res; 2019 Sep; 147():104342. PubMed ID: 31288079
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Transient expression of thyrotropin releasing hormone peptide and mRNA in the rat hippocampus following global cerebral ischemia/reperfusion injury.
    Xiang Z; Xu XH; Knight GE; Burnstock G
    Int J Neurosci; 2022 Aug; 132(8):787-801. PubMed ID: 33080155
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Transplanted astrocytes internalize deposited beta-amyloid peptides in a transgenic mouse model of Alzheimer's disease.
    Pihlaja R; Koistinaho J; Malm T; Sikkilä H; Vainio S; Koistinaho M
    Glia; 2008 Jan; 56(2):154-63. PubMed ID: 18004725
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Glutaminyl cyclase inhibitor exhibits anti-inflammatory effects in both AD and LPS-induced inflammatory model mice.
    Wang X; Wang L; Yu X; Li Y; Liu Z; Zou Y; Zheng Y; He Z; Wu H
    Int Immunopharmacol; 2019 Oct; 75():105770. PubMed ID: 31377588
    [TBL] [Abstract][Full Text] [Related]  

  • 33. An overview of glutaminyl cyclase inhibitors for Alzheimer's disease.
    Coimbra JR; Sobral PJ; Santos AE; Moreira PI; Salvador JA
    Future Med Chem; 2019 Dec; 11(24):3179-3194. PubMed ID: 31838899
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Combination of the Glutaminyl Cyclase Inhibitor PQ912 (Varoglutamstat) and the Murine Monoclonal Antibody PBD-C06 (m6) Shows Additive Effects on Brain Aβ Pathology in Transgenic Mice.
    Hoffmann T; Rahfeld JU; Schenk M; Ponath F; Makioka K; Hutter-Paier B; Lues I; Lemere CA; Schilling S
    Int J Mol Sci; 2021 Oct; 22(21):. PubMed ID: 34769222
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Identification of N-terminally truncated pyroglutamate amyloid-β in cholesterol-enriched diet-fed rabbit and AD brain.
    Perez-Garmendia R; Hernandez-Zimbron LF; Morales MA; Luna-Muñoz J; Mena R; Nava-Catorce M; Acero G; Vasilevko V; Viramontes-Pintos A; Cribbs DH; Gevorkian G
    J Alzheimers Dis; 2014; 39(2):441-55. PubMed ID: 24240639
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Effects of a tacrine-8-hydroxyquinoline hybrid (IQM-622) on Aβ accumulation and cell death: involvement in hippocampal neuronal loss in Alzheimer's disease.
    Antequera D; Bolos M; Spuch C; Pascual C; Ferrer I; Fernandez-Bachiller MI; Rodríguez-Franco MI; Carro E
    Neurobiol Dis; 2012 Jun; 46(3):682-91. PubMed ID: 22426395
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Glucocorticoids facilitate astrocytic amyloid-β peptide deposition by increasing the expression of APP and BACE1 and decreasing the expression of amyloid-β-degrading proteases.
    Wang Y; Li M; Tang J; Song M; Xu X; Xiong J; Li J; Bai Y
    Endocrinology; 2011 Jul; 152(7):2704-15. PubMed ID: 21558319
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Potent human glutaminyl cyclase inhibitors as potential anti-Alzheimer's agents: Structure-activity relationship study of Arg-mimetic region.
    Ngo VTH; Hoang VH; Tran PT; Ann J; Cui M; Park G; Choi S; Lee J; Kim H; Ha HJ; Choi K; Kim YH; Lee J
    Bioorg Med Chem; 2018 Mar; 26(5):1035-1049. PubMed ID: 29398442
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Increased hippocampal neurogenesis in the progressive stage of Alzheimer's disease phenotype in an APP/PS1 double transgenic mouse model.
    Yu Y; He J; Zhang Y; Luo H; Zhu S; Yang Y; Zhao T; Wu J; Huang Y; Kong J; Tan Q; Li XM
    Hippocampus; 2009 Dec; 19(12):1247-53. PubMed ID: 19309037
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Discovery of highly potent human glutaminyl cyclase (QC) inhibitors as anti-Alzheimer's agents by the combination of pharmacophore-based and structure-based design.
    Van Manh N; Hoang VH; Ngo VTH; Ann J; Jang TH; Ha JH; Song JY; Ha HJ; Kim H; Kim YH; Lee J; Lee J
    Eur J Med Chem; 2021 Dec; 226():113819. PubMed ID: 34536669
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 8.