BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

90 related articles for article (PubMed ID: 25451572)

  • 1. The role of the efflux carriers Abcg2 and Abcc2 for the hepatobiliary elimination of benzo[a]pyrene and its metabolites in mice.
    Kranz J; Hessel S; Aretz J; Seidel A; Petzinger E; Geyer J; Lampen A
    Chem Biol Interact; 2014 Dec; 224():36-41. PubMed ID: 25451572
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Altered hepatobiliary disposition of 5 (and 6)-carboxy-2',7'-dichlorofluorescein in Abcg2 (Bcrp1) and Abcc2 (Mrp2) knockout mice.
    Nezasa K; Tian X; Zamek-Gliszczynski MJ; Patel NJ; Raub TJ; Brouwer KL
    Drug Metab Dispos; 2006 Apr; 34(4):718-23. PubMed ID: 16434545
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Functionally overlapping roles of Abcg2 (Bcrp1) and Abcc2 (Mrp2) in the elimination of methotrexate and its main toxic metabolite 7-hydroxymethotrexate in vivo.
    Vlaming ML; Pala Z; van Esch A; Wagenaar E; de Waart DR; van de Wetering K; van der Kruijssen CM; Oude Elferink RP; van Tellingen O; Schinkel AH
    Clin Cancer Res; 2009 May; 15(9):3084-93. PubMed ID: 19383815
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Complex pharmacokinetic behavior of ezetimibe depends on abcc2, abcc3, and abcg2.
    de Waart DR; Vlaming ML; Kunne C; Schinkel AH; Oude Elferink RP
    Drug Metab Dispos; 2009 Aug; 37(8):1698-702. PubMed ID: 19443695
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Impact of abcc2 [multidrug resistance-associated protein (MRP) 2], abcc3 (MRP3), and abcg2 (breast cancer resistance protein) on the oral pharmacokinetics of methotrexate and its main metabolite 7-hydroxymethotrexate.
    Vlaming ML; van Esch A; van de Steeg E; Pala Z; Wagenaar E; van Tellingen O; Schinkel AH
    Drug Metab Dispos; 2011 Aug; 39(8):1338-44. PubMed ID: 21566011
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Abcc2 (Mrp2), Abcc3 (Mrp3), and Abcg2 (Bcrp1) are the main determinants for rapid elimination of methotrexate and its toxic metabolite 7-hydroxymethotrexate in vivo.
    Vlaming ML; van Esch A; Pala Z; Wagenaar E; van de Wetering K; van Tellingen O; Schinkel AH
    Mol Cancer Ther; 2009 Dec; 8(12):3350-9. PubMed ID: 19996279
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Hepatic transport mechanisms of cholyl-L-lysyl-fluorescein.
    de Waart DR; Häusler S; Vlaming ML; Kunne C; Hänggi E; Gruss HJ; Oude Elferink RP; Stieger B
    J Pharmacol Exp Ther; 2010 Jul; 334(1):78-86. PubMed ID: 20388726
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Influence of efflux transporters on liver, bile and brain disposition of amitriptyline in mice.
    Abaut AY; Chevanne F; Le Corre P
    Int J Pharm; 2009 Aug; 378(1-2):80-5. PubMed ID: 19508886
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Overlapping functions of ABC transporters in topotecan disposition as determined in gene knockout mouse models.
    Tiwari AK; Zhang R; Gallo JM
    Mol Cancer Ther; 2013 Jul; 12(7):1343-55. PubMed ID: 23635651
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The breast cancer resistance protein (BCRP/ABCG2) affects pharmacokinetics, hepatobiliary excretion, and milk secretion of the antibiotic nitrofurantoin.
    Merino G; Jonker JW; Wagenaar E; van Herwaarden AE; Schinkel AH
    Mol Pharmacol; 2005 May; 67(5):1758-64. PubMed ID: 15709111
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Hepatic clearance of reactive glucuronide metabolites of diclofenac in the mouse is dependent on multiple ATP-binding cassette efflux transporters.
    Lagas JS; Sparidans RW; Wagenaar E; Beijnen JH; Schinkel AH
    Mol Pharmacol; 2010 Apr; 77(4):687-94. PubMed ID: 20086033
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Multidrug resistance-associated proteins are involved in the transport of the glutathione conjugates of the ultimate carcinogen of benzo[a]pyrene in human Caco-2 cells.
    Hessel S; John A; Seidel A; Lampen A
    Arch Toxicol; 2013 Feb; 87(2):269-80. PubMed ID: 22899102
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Impact of Abcc2 (Mrp2) and Abcc3 (Mrp3) on the in vivo elimination of methotrexate and its main toxic metabolite 7-hydroxymethotrexate.
    Vlaming ML; Pala Z; van Esch A; Wagenaar E; van Tellingen O; de Waart DR; Oude Elferink RP; van de Wetering K; Schinkel AH
    Clin Cancer Res; 2008 Dec; 14(24):8152-60. PubMed ID: 19088030
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Improved extrapolation of hepatobiliary clearance from in vitro sandwich cultured rat hepatocytes through absolute quantification of hepatobiliary transporters.
    Li N; Singh P; Mandrell KM; Lai Y
    Mol Pharm; 2010 Jun; 7(3):630-41. PubMed ID: 20438085
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Impact of basolateral multidrug resistance-associated protein (Mrp) 3 and Mrp4 on the hepatobiliary disposition of fexofenadine in perfused mouse livers.
    Tian X; Swift B; Zamek-Gliszczynski MJ; Belinsky MG; Kruh GD; Brouwer KL
    Drug Metab Dispos; 2008 May; 36(5):911-5. PubMed ID: 18276836
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Dose-dependent disposition of methotrexate in Abcc2 and Abcc3 gene knockout murine models.
    Wang Z; Zhou Q; Kruh GD; Gallo JM
    Drug Metab Dispos; 2011 Nov; 39(11):2155-61. PubMed ID: 21841039
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Hepatocyte-Specific Deletion of EGFR in Mice Reduces Hepatic Abcg2 Transport Activity Measured by [
    Traxl A; Komposch K; Glitzner E; Wanek T; Mairinger S; Langer O; Sibilia M
    Drug Metab Dispos; 2017 Oct; 45(10):1093-1100. PubMed ID: 28790147
    [TBL] [Abstract][Full Text] [Related]  

  • 18. P-glycoprotein (P-gp/Abcb1), Abcc2, and Abcc3 determine the pharmacokinetics of etoposide.
    Lagas JS; Fan L; Wagenaar E; Vlaming ML; van Tellingen O; Beijnen JH; Schinkel AH
    Clin Cancer Res; 2010 Jan; 16(1):130-40. PubMed ID: 20028753
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Carcinogen and anticancer drug transport by Mrp2 in vivo: studies using Mrp2 (Abcc2) knockout mice.
    Vlaming ML; Mohrmann K; Wagenaar E; de Waart DR; Elferink RP; Lagas JS; van Tellingen O; Vainchtein LD; Rosing H; Beijnen JH; Schellens JH; Schinkel AH
    J Pharmacol Exp Ther; 2006 Jul; 318(1):319-27. PubMed ID: 16611851
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Metabolism of benzo[a]pyrene in the perfused rat liver: factors affecting the release of phenolic metabolites into the bile and perfusate.
    Sweeny DJ; Reinke LA
    Carcinogenesis; 1987 Jun; 8(6):779-83. PubMed ID: 3608074
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 5.