These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

247 related articles for article (PubMed ID: 25453083)

  • 1. Toward resolving the catalytic mechanism of dihydrofolate reductase using neutron and ultrahigh-resolution X-ray crystallography.
    Wan Q; Bennett BC; Wilson MA; Kovalevsky A; Langan P; Howell EE; Dealwis C
    Proc Natl Acad Sci U S A; 2014 Dec; 111(51):18225-30. PubMed ID: 25453083
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Energetically most likely substrate and active-site protonation sites and pathways in the catalytic mechanism of dihydrofolate reductase.
    Cummins PL; Gready JE
    J Am Chem Soc; 2001 Apr; 123(15):3418-28. PubMed ID: 11472112
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Role of water in the catalytic cycle of E. coli dihydrofolate reductase.
    Shrimpton P; Allemann RK
    Protein Sci; 2002 Jun; 11(6):1442-51. PubMed ID: 12021443
    [TBL] [Abstract][Full Text] [Related]  

  • 4. How dihydrofolate reductase facilitates protonation of dihydrofolate.
    Rod TH; Brooks CL
    J Am Chem Soc; 2003 Jul; 125(29):8718-9. PubMed ID: 12862454
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Conformational changes in the active site loops of dihydrofolate reductase during the catalytic cycle.
    Venkitakrishnan RP; Zaborowski E; McElheny D; Benkovic SJ; Dyson HJ; Wright PE
    Biochemistry; 2004 Dec; 43(51):16046-55. PubMed ID: 15609999
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Capturing the Catalytic Proton of Dihydrofolate Reductase: Implications for General Acid-Base Catalysis.
    Wan Q; Bennett BC; Wymore T; Li Z; Wilson MA; Brooks CL; Langan P; Kovalevsky A; Dealwis CG
    ACS Catal; 2021 May; 11(9):5873-5884. PubMed ID: 34055457
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Neutron diffraction studies of Escherichia coli dihydrofolate reductase complexed with methotrexate.
    Bennett B; Langan P; Coates L; Mustyakimov M; Schoenborn B; Howell EE; Dealwis C
    Proc Natl Acad Sci U S A; 2006 Dec; 103(49):18493-8. PubMed ID: 17130456
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Determination by Raman spectroscopy of the pKa of N5 of dihydrofolate bound to dihydrofolate reductase: mechanistic implications.
    Chen YQ; Kraut J; Blakley RL; Callender R
    Biochemistry; 1994 Jun; 33(23):7021-6. PubMed ID: 8003467
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Crystal structures of Escherichia coli dihydrofolate reductase complexed with 5-formyltetrahydrofolate (folinic acid) in two space groups: evidence for enolization of pteridine O4.
    Lee H; Reyes VM; Kraut J
    Biochemistry; 1996 Jun; 35(22):7012-20. PubMed ID: 8679526
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Crystal structure of chicken liver dihydrofolate reductase complexed with NADP+ and biopterin.
    McTigue MA; Davies JF; Kaufman BT; Kraut J
    Biochemistry; 1992 Aug; 31(32):7264-73. PubMed ID: 1510919
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Functional role for Tyr 31 in the catalytic cycle of chicken dihydrofolate reductase.
    Shrimpton P; Mullaney A; Allemann RK
    Proteins; 2003 May; 51(2):216-23. PubMed ID: 12660990
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence.
    Sawaya MR; Kraut J
    Biochemistry; 1997 Jan; 36(3):586-603. PubMed ID: 9012674
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Preliminary joint X-ray and neutron protein crystallographic studies of ecDHFR complexed with folate and NADP+.
    Wan Q; Kovalevsky AY; Wilson MA; Bennett BC; Langan P; Dealwis C
    Acta Crystallogr F Struct Biol Commun; 2014 Jun; 70(Pt 6):814-8. PubMed ID: 24915100
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Vibrational structure of dihydrofolate bound to R67 dihydrofolate reductase.
    Deng H; Callender R; Howell E
    J Biol Chem; 2001 Dec; 276(52):48956-60. PubMed ID: 11679579
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Backbone dynamics in dihydrofolate reductase complexes: role of loop flexibility in the catalytic mechanism.
    Osborne MJ; Schnell J; Benkovic SJ; Dyson HJ; Wright PE
    Biochemistry; 2001 Aug; 40(33):9846-59. PubMed ID: 11502178
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Strength of an interloop hydrogen bond determines the kinetic pathway in catalysis by Escherichia coli dihydrofolate reductase.
    Miller GP; Benkovic SJ
    Biochemistry; 1998 May; 37(18):6336-42. PubMed ID: 9572848
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Histidine hydrogen-deuterium exchange mass spectrometry for probing the microenvironment of histidine residues in dihydrofolate reductase.
    Miyagi M; Wan Q; Ahmad MF; Gokulrangan G; Tomechko SE; Bennett B; Dealwis C
    PLoS One; 2011 Feb; 6(2):e17055. PubMed ID: 21359214
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Conformational change of the methionine 20 loop of Escherichia coli dihydrofolate reductase modulates pKa of the bound dihydrofolate.
    Khavrutskii IV; Price DJ; Lee J; Brooks CL
    Protein Sci; 2007 Jun; 16(6):1087-100. PubMed ID: 17473015
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Role of Active Site Loop Dynamics in Mediating Ligand Release from
    Singh A; Fenwick RB; Dyson HJ; Wright PE
    Biochemistry; 2021 Sep; 60(35):2663-2671. PubMed ID: 34428034
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Allosteric communication in dihydrofolate reductase: signaling network and pathways for closed to occluded transition and back.
    Chen J; Dima RI; Thirumalai D
    J Mol Biol; 2007 Nov; 374(1):250-66. PubMed ID: 17916364
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.