233 related articles for article (PubMed ID: 25455859)
1. Rational design of small molecule inhibitors targeting the Ras GEF, SOS1.
Evelyn CR; Duan X; Biesiada J; Seibel WL; Meller J; Zheng Y
Chem Biol; 2014 Dec; 21(12):1618-28. PubMed ID: 25455859
[TBL] [Abstract][Full Text] [Related]
2. Combined rational design and a high throughput screening platform for identifying chemical inhibitors of a Ras-activating enzyme.
Evelyn CR; Biesiada J; Duan X; Tang H; Shang X; Papoian R; Seibel WL; Nelson S; Meller J; Zheng Y
J Biol Chem; 2015 May; 290(20):12879-98. PubMed ID: 25825487
[TBL] [Abstract][Full Text] [Related]
3. Small Molecule-Mediated Activation of RAS Elicits Biphasic Modulation of Phospho-ERK Levels that Are Regulated through Negative Feedback on SOS1.
Howes JE; Akan DT; Burns MC; Rossanese OW; Waterson AG; Fesik SW
Mol Cancer Ther; 2018 May; 17(5):1051-1060. PubMed ID: 29440291
[TBL] [Abstract][Full Text] [Related]
4. Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction.
Hillig RC; Sautier B; Schroeder J; Moosmayer D; Hilpmann A; Stegmann CM; Werbeck ND; Briem H; Boemer U; Weiske J; Badock V; Mastouri J; Petersen K; Siemeister G; Kahmann JD; Wegener D; Böhnke N; Eis K; Graham K; Wortmann L; von Nussbaum F; Bader B
Proc Natl Acad Sci U S A; 2019 Feb; 116(7):2551-2560. PubMed ID: 30683722
[TBL] [Abstract][Full Text] [Related]
5. Targeting RAS oncogenesis with SOS1 inhibitors.
Hillig RC; Bader B
Adv Cancer Res; 2022; 153():169-203. PubMed ID: 35101230
[TBL] [Abstract][Full Text] [Related]
6. Anthraquinones as Inhibitors of SOS RAS-GEF Activity.
Fernández-Medarde A; Fuentes-Mateos R; García-Navas R; Juan AO; Sánchez-López JM; Fernández-Medarde A; Santos E
Biomolecules; 2021 Jul; 11(8):. PubMed ID: 34439794
[TBL] [Abstract][Full Text] [Related]
7. CIIA negatively regulates the Ras-Erk1/2 signaling pathway through inhibiting the Ras-specific GEF activity of SOS1.
Hwang HS; Hwang SG; Yoon KW; Yoon JH; Roh KH; Choi EJ
J Cell Sci; 2014 Apr; 127(Pt 8):1640-6. PubMed ID: 24522193
[TBL] [Abstract][Full Text] [Related]
8. New avenue to inhibit Ras signaling.
Bustelo XR
Chem Biol; 2014 Dec; 21(12):1599-600. PubMed ID: 25525987
[TBL] [Abstract][Full Text] [Related]
9. Discovery of Aminopiperidine Indoles That Activate the Guanine Nucleotide Exchange Factor SOS1 and Modulate RAS Signaling.
Abbott JR; Hodges TR; Daniels RN; Patel PA; Kennedy JP; Howes JE; Akan DT; Burns MC; Sai J; Sobolik T; Beesetty Y; Lee T; Rossanese OW; Phan J; Waterson AG; Fesik SW
J Med Chem; 2018 Jul; 61(14):6002-6017. PubMed ID: 29856609
[TBL] [Abstract][Full Text] [Related]
10. High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling.
Burns MC; Howes JE; Sun Q; Little AJ; Camper DV; Abbott JR; Phan J; Lee T; Waterson AG; Rossanese OW; Fesik SW
Anal Biochem; 2018 May; 548():44-52. PubMed ID: 29444450
[TBL] [Abstract][Full Text] [Related]
11. Small molecule Son of Sevenless 1 (SOS1) inhibitors: a review of the patent literature.
Thompson SK; Buckl A; Dossetter AG; Griffen E; Gill A
Expert Opin Ther Pat; 2021 Dec; 31(12):1189-1204. PubMed ID: 34253125
[No Abstract] [Full Text] [Related]
12. Germline gain-of-function mutations in SOS1 cause Noonan syndrome.
Roberts AE; Araki T; Swanson KD; Montgomery KT; Schiripo TA; Joshi VA; Li L; Yassin Y; Tamburino AM; Neel BG; Kucherlapati RS
Nat Genet; 2007 Jan; 39(1):70-4. PubMed ID: 17143285
[TBL] [Abstract][Full Text] [Related]
13. SOS1 over-expression in genital skin fibroblasts from hirsute women: a putative role of the SOS1/RAS pathway in the pathogenesis of hirsutism.
Minella D; Wannenes F; Biancolella M; Amati F; Testa B; Nardone A; Bueno S; Fabbri A; Lauro D; Novelli G; Moretti C
J Biol Regul Homeost Agents; 2011; 25(4):615-26. PubMed ID: 22217993
[TBL] [Abstract][Full Text] [Related]
14. An activating mutation in sos-1 identifies its Dbl domain as a critical inhibitor of the epidermal growth factor receptor pathway during Caenorhabditis elegans vulval development.
Modzelewska K; Elgort MG; Huang J; Jongeward G; Lauritzen A; Yoon CH; Sternberg PW; Moghal N
Mol Cell Biol; 2007 May; 27(10):3695-707. PubMed ID: 17339331
[TBL] [Abstract][Full Text] [Related]
15. Allosteric KRas4B Can Modulate SOS1 Fast and Slow Ras Activation Cycles.
Liao TJ; Jang H; Fushman D; Nussinov R
Biophys J; 2018 Aug; 115(4):629-641. PubMed ID: 30097175
[TBL] [Abstract][Full Text] [Related]
16. Guanine nucleotide exchange factors: activators of Ras superfamily proteins.
Overbeck AF; Brtva TR; Cox AD; Graham SM; Huff SY; Khosravi-Far R; Quilliam LA; Solski PA; Der CJ
Mol Reprod Dev; 1995 Dec; 42(4):468-76. PubMed ID: 8607978
[TBL] [Abstract][Full Text] [Related]
17. Small molecule binding sites on the Ras:SOS complex can be exploited for inhibition of Ras activation.
Winter JJ; Anderson M; Blades K; Brassington C; Breeze AL; Chresta C; Embrey K; Fairley G; Faulder P; Finlay MR; Kettle JG; Nowak T; Overman R; Patel SJ; Perkins P; Spadola L; Tart J; Tucker JA; Wrigley G
J Med Chem; 2015 Mar; 58(5):2265-74. PubMed ID: 25695162
[TBL] [Abstract][Full Text] [Related]
18. SOS1-inspired hydrocarbon-stapled peptide as a pan-Ras inhibitor.
Li A; Li X; Zou J; Zhuo X; Chen S; Chai X; Gai C; Xu W; Zhao Q; Zou Y
Bioorg Chem; 2023 Jun; 135():106500. PubMed ID: 37003134
[TBL] [Abstract][Full Text] [Related]
19. Identification and Characterization of Oncogenic
Cai D; Choi PS; Gelbard M; Meyerson M
Mol Cancer Res; 2019 Apr; 17(4):1002-1012. PubMed ID: 30635434
[TBL] [Abstract][Full Text] [Related]
20. Direct inhibition of oncogenic KRAS by Bacillus pumilus ribonuclease (binase).
Ilinskaya ON; Singh I; Dudkina E; Ulyanova V; Kayumov A; Barreto G
Biochim Biophys Acta; 2016 Jul; 1863(7 Pt A):1559-67. PubMed ID: 27066977
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]