BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

278 related articles for article (PubMed ID: 25458540)

  • 1. Computational studies to predict or explain G protein coupled receptor polypharmacology.
    Jacobson KA; Costanzi S; Paoletta S
    Trends Pharmacol Sci; 2014 Dec; 35(12):658-63. PubMed ID: 25458540
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Addressing selective polypharmacology of antipsychotic drugs targeting the bioaminergic receptors through receptor dynamic conformational ensembles.
    Selvam B; Porter SL; Tikhonova IG
    J Chem Inf Model; 2013 Jul; 53(7):1761-74. PubMed ID: 23789628
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Quantitative and systems pharmacology 2. In silico polypharmacology of G protein-coupled receptor ligands via network-based approaches.
    Wu Z; Lu W; Yu W; Wang T; Li W; Liu G; Zhang H; Pang X; Huang J; Liu M; Cheng F; Tang Y
    Pharmacol Res; 2018 Mar; 129():400-413. PubMed ID: 29133212
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Chemical Diversity in the G Protein-Coupled Receptor Superfamily.
    Vass M; Kooistra AJ; Yang D; Stevens RC; Wang MW; de Graaf C
    Trends Pharmacol Sci; 2018 May; 39(5):494-512. PubMed ID: 29576399
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Improving virtual screening of G protein-coupled receptors via ligand-directed modeling.
    Coudrat T; Simms J; Christopoulos A; Wootten D; Sexton PM
    PLoS Comput Biol; 2017 Nov; 13(11):e1005819. PubMed ID: 29131821
    [TBL] [Abstract][Full Text] [Related]  

  • 6. New insights for drug design from the X-ray crystallographic structures of G-protein-coupled receptors.
    Jacobson KA; Costanzi S
    Mol Pharmacol; 2012 Sep; 82(3):361-71. PubMed ID: 22695719
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Established and In-trial GPCR Families in Clinical Trials: A Review for Target Selection.
    Saikia S; Bordoloi M; Sarmah R
    Curr Drug Targets; 2019; 20(5):522-539. PubMed ID: 30394207
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Chemoproteomic Approach to Explore the Target Profile of GPCR ligands: Application to 5-HT1A and 5-HT6 Receptors.
    Gamo AM; González-Vera JA; Rueda-Zubiaurre A; Alonso D; Vázquez-Villa H; Martín-Couce L; Palomares Ó; López JA; Martín-Fontecha M; Benhamú B; López-Rodríguez ML; Ortega-Gutiérrez S
    Chemistry; 2016 Jan; 22(4):1313-21. PubMed ID: 26560738
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Current and Future Challenges in GPCR Drug Discovery.
    Topiol S
    Methods Mol Biol; 2018; 1705():1-21. PubMed ID: 29188556
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Structural insights into ligand recognition and selectivity for classes A, B, and C GPCRs.
    Lee SM; Booe JM; Pioszak AA
    Eur J Pharmacol; 2015 Sep; 763(Pt B):196-205. PubMed ID: 25981303
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Breakthrough in GPCR Crystallography and Its Impact on Computer-Aided Drug Design.
    Ciancetta A; Jacobson KA
    Methods Mol Biol; 2018; 1705():45-72. PubMed ID: 29188558
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Structural probing of off-target G protein-coupled receptor activities within a series of adenosine/adenine congeners.
    Paoletta S; Tosh DK; Salvemini D; Jacobson KA
    PLoS One; 2014; 9(5):e97858. PubMed ID: 24859150
    [TBL] [Abstract][Full Text] [Related]  

  • 13. A Molecular Pharmacologist's Guide to G Protein-Coupled Receptor Crystallography.
    Piscitelli CL; Kean J; de Graaf C; Deupi X
    Mol Pharmacol; 2015 Sep; 88(3):536-51. PubMed ID: 26152196
    [TBL] [Abstract][Full Text] [Related]  

  • 14. New paradigms in GPCR drug discovery.
    Jacobson KA
    Biochem Pharmacol; 2015 Dec; 98(4):541-55. PubMed ID: 26265138
    [TBL] [Abstract][Full Text] [Related]  

  • 15. X-ray structure breakthroughs in the GPCR transmembrane region.
    Topiol S; Sabio M
    Biochem Pharmacol; 2009 Jul; 78(1):11-20. PubMed ID: 19447219
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Recent Advances in Structure-Based Drug Design Targeting Class A G Protein-Coupled Receptors Utilizing Crystal Structures and Computational Simulations.
    Lee Y; Basith S; Choi S
    J Med Chem; 2018 Jan; 61(1):1-46. PubMed ID: 28657745
    [TBL] [Abstract][Full Text] [Related]  

  • 17. GPCR crystal structures: Medicinal chemistry in the pocket.
    Shonberg J; Kling RC; Gmeiner P; Löber S
    Bioorg Med Chem; 2015 Jul; 23(14):3880-906. PubMed ID: 25638496
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Integrating Pharmacophore into Membrane Molecular Dynamics Simulations to Improve Homology Modeling of G Protein-coupled Receptors with Ligand Selectivity: A2A Adenosine Receptor as an Example.
    Zeng L; Guan M; Jin H; Liu Z; Zhang L
    Chem Biol Drug Des; 2015 Dec; 86(6):1438-50. PubMed ID: 26072970
    [TBL] [Abstract][Full Text] [Related]  

  • 19. G Protein-Coupled Receptors: target-based in silico screening.
    Senderowitz H; Marantz Y
    Curr Pharm Des; 2009; 15(35):4049-68. PubMed ID: 20028321
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Computational approaches for ligand discovery and design in class-A G protein- coupled receptors.
    Rodríguez D; Gutiérrez-de-Terán H
    Curr Pharm Des; 2013; 19(12):2216-36. PubMed ID: 23016842
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.